P2X Receptor

P2X Receptor

Seven cation permeable ligand-gated ion channels (LGICs) known as P2X receptors (P2X1R-P2X7R) are a family of LGICs that open in response to the extracellular ligand adenosine 5′-triphosphate (ATP) binding. P2X receptors are widely expressed in the nervous, immune, cardiovascular, skeletal, gastrointestinal, respiratory, and endocrine systems and have a high permeability to Ca2+, Na+, and K+.

P2X receptors are extensively expressed in both excitatory and non-excitatory cells, including neuron, glia, platelet, epithelia, and macrophages. They play a key role in a number of critical physiological and pathological processes, such as synaptic transmission, pain perception, inflammation, cardiovascular regulation, immune modulation, and tumorigenesis.

P2X Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(E/Z)-Sivopixant ((E/Z)-S-600918) V73562 (E/Z)-Sivopixant ((E/Z)-S-600918) 1640808-39-4 (E/Z)-Sivopixant ((E/Z)-S-600918) is a potent P2X3 receptor antagonist (inhibitor) with IC50 of 4 nM.
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate; 8-Br-ATP) V73572 8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate; 8-Br-ATP) 23567-97-7 8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analog, is an agonist of the purinergic P2X receptor.
A 438079 V28878 A 438079 899507-36-9 A-438079 HCl is a novel, potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
A-317491 V2791 A-317491 475205-49-3 A-317491 is a selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, which inhibits calcium flux mediated by the receptors.
A-317491 Sodium V3090 A-317491 Sodium 475205-49-3 A-317491 sodium, the tri-sodium salt of A-317491, which is a selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, which inhibits calcium flux mediated by the receptors.
AZD9056 hydrochloride V4252 AZD9056 hydrochloride 345303-91-5 AZD9056 hydrochloride is a novel, potent, selective, orally bioavailable antagonist of P2X7 receptor which is an adenosine triphosphate (ATP)-gated cation channel expressed on a variety of cell types believed to play a role in inflammation.
BzATP triethylammonium salt V77178 BzATP triethylammonium salt BzATP triethylammonium salt is a P2X receptor agonist/activator with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31 and 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7 respectively.
Camlipixant (BLU-5937) V73561 Camlipixant (BLU-5937) 1621164-74-6 Camlipixant (BLU-5937) is a specific, noncompetitive and orally bioactive P2X3 homotrimer receptor antagonist (inhibitor) with IC50 of 25 nM for hP2X3 homotrimer.
EVT-401 V77029 EVT-401 EVT-401 (P2X7 receptor blocker (antagonist)-1) is a purinergic P2X7 receptor blocker (antagonist).
Filapixant (BAY 1902607) V73563 Filapixant (BAY 1902607) 1948232-63-0 Filapixant is a purinergic receptor antagonist.
Gefapixant (AF219; MK-7264) V2116 Gefapixant (AF219; MK-7264) 1015787-98-0 Gefapixant (also known as AF-219 and MK-7264) is a novel, potent, and orally bioactive P2X3 receptor (P2X3R) antagonist with antitussive effects, and may be used forchronic cough.
GW791343 trihydrochloride V4926 GW791343 trihydrochloride 1019779-04-4 GW-791343 3HCl, thetrihydrochloride salt form ofGW-791343 (GW791343) is a novel, potent P2X7 allosteric modulator that exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 with pIC50 of 6.9 - 7.2.
GW791343 trihydrochloride V73582 GW791343 trihydrochloride 309712-55-8 GW791343 tri HCl is a potent NAM (negative allosteric modulator) (species-specific) of human P2X7 receptor, which produces noncompetitive antagonism to human P2X7 receptor, with pIC50 of 6.9-7.2.
H-Lys-Tyr-OH TFA (Lysyltyrosine TFA) V80047 H-Lys-Tyr-OH TFA (Lysyltyrosine TFA) H-Lys-Tyr-OH TFA (Lysyltyrosine TFA) is a dipeptide consisting of L-lysine and L-tyrosine.
Indophagolin V2339 Indophagolin 1207660-00-1 Indophagolin is a potent indoline-containing autophagy inhibitor (IC50=140 nM).
Iso-PPADS tetrasodium V73581 Iso-PPADS tetrasodium 207572-67-6 Iso-PPADS tetrasodium is a P2X-purinoceptor receptor antagonist.
ITH15004 V85134 ITH15004 2600675-12-3
JNJ-54166060 V73578 JNJ-54166060 1627900-41-7 JNJ-54166060 is a P2X7 receptor blocker (antagonist), with IC50s of 4/115/72 nM for human/rat/mouse P2X7 receptors respectively.
JNJ-55308942 V73559 JNJ-55308942 2166558-11-6 JNJ-55308942 is a high-affinity, selective, BBB (blood-brain barrier) permeable (penetrable) P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM).
Lu AF27139 V2508 Lu AF27139 2097117-06-9 Lu AF27139a novel rodent-active and CNS-penetrant P2X7 receptor antagonist, which is highly selective and potent against rat, mouse, and human forms of the receptors.
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