LXRs (Liver X Receptor and ) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. As oxysterol-activated transcription factors, LXRs promote the coordinated mobilization of extra cholesterol from cells and the body by upregulating a group of genes. The LXRs, like other nuclear receptors, have anti-inflammatory properties. They prevent nuclear factor-B, activating protein-1, and other transcription factors from signaling-dependently inducing pro-inflammatory genes.
The liver, kidney, macrophages, and adipose tissue are among the tissues with the highest levels of LXR expression. However, LXR expression is pervasive. A growing body of research indicates that selective LXR agonists can mitigate the high triglyceride production that results from activating LXR, which is primarily expressed in the liver.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V67750 | 22(R)-Hydroxycholesterol (Narthesterol) | 17954-98-2 | 22(R)-Hydroxycholesterol (Narthesterol) is an endogenous LXR agonist. |
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V3965 | Abequolixron (RGX-104) | 610318-54-2 | Abequolixron (formerly known as SB742881; RG104; SB-742881) is a novel potent and orally bioavailable liver-X nuclear hormone receptor-beta (LXR)agonist with potential immunomodulating and anticancer activities. |
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V3966 | Abequolixron (RGX-104) HCl | 610318-03-1 | AbequolixronHCl (formerly RGX-104; SB-742881; SB742881), the hydrochloride salt ofRGX104, is a novel potent and orally bioavailable liver-X nuclear hormone receptor-beta (LXR)agonist that modulates innate immunity via transcriptional activation of the ApoE gene. |
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V67752 | Acetyl podocarpic acid anhydride (Acetylpodocarpic dimer; APD) | 344327-48-6 | Acetyl podocarpic acid anhydride is a potent, semisynthetic liver X receptor (LXR) agonist derived from apple extract. |
|
V4156 | AZ876 | 898800-26-5 | AZ-876 is a novel, potent high-affinity agonist of Liver X Receptor (LXR)with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively. |
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V3482 | BMS-779788 | 918348-67-1 | BMS-779788 (formerlyknown as XL-652, EXEL 04286652 and BMS-788) is a novel and potentLXR (Liver X Receptors)partial agonist withIC50values of 68 nM for LXRαand 14 nM for LXRβ. |
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V3502 | BMS-852927 | 1256918-39-4 | BMS-852927 (also known as XL041) is a partial agonist ofLXRβ (liver X receptor β). |
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V67749 | DMHCA | 79066-03-8 | DMHCA is a potent and specific LXR agonist that specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. |
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V67751 | FITC-GW3965 | 2374144-23-5 | FITC-GW3965 is a fluorescently labeled liver X receptor beta (LXRβ) agonist GW3965. |
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V3560 | GSK-2033 | 1221277-90-2 | GSK2033 is a novel, potent and cell-active LXR (liver X receptor) antagonist withpIC50s of 7 and 7.4 forLXRαorLXRβ. |
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V30595 | GW3965 | 405911-09-3 | GW3965 (GW-3965) is a novel, potent, selective LXR (liver X receptor) agonist for hLXRα and hLXRβ with anti-inflammatory effects. |
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V1852 | GW3965 HCl | 405911-17-3 | GW3965 (GW-3965) HCl, the hydrochloride salt ofGW3965, is a novel, potent, selective LXR (liver X receptor) agonist for hLXRα and hLXRβ with potential anti-inflammatory activity. |
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V60091 | Iristectorigenin B | 86849-77-6 | Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. |
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V2912 | LXR623 | 875787-07-8 | LXR623 (WAY-252623; LXR-623) is a novel, highly brain-penetrant, selective and orally bioavailable synthetic modulator of LXR (Liver X receptor) with anticancer activity, It is a partial LXRα and full LXRβ agonist with IC50s of 24 nM and 179 nM, respectively. |
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V67753 | LXRagonist 2 | 2978788-07-5 | LXR agonist 2 (compound 18rr) is a potent LXR (liver X receptor) agonist. |
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V78121 | LXRβagonist-4 | LXRβ agonist-4 is an orally bioavailable inhibitor of liver X receptors (LXRs) with IC50 of 0.0078 μM for LXRβ. | |
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V4045 | SR9238 | 1416153-62-2 | SR9238 is the first selective syntheticLXR(Liver Xreceptor) inverse antagonist withIC50s of 214 nM and 43 nM forLXRαandLXRβ, respectively. |
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V1854 | SR9243 | 1613028-81-1 | SR9243 (SR-9243) is a potent and selective inverse agonist ofLXR. |
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V1853 | T0901317 (T-1317) | 293754-55-9 | T0901317 (formerly known as T-1317 or TO-091317 or TO 901317)is a potentand selective liver X receptor (LXR) agonist for multiple targets, which has EC50 values of 20 nM and 5 μM for LXRα and FXR, respectively. |
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