Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids.The reducing equivalents NADH and FADH2, which transfer their electrons to the electron transport chain, are produced by these carbon fuels by feeding into the TCA cycle in the mitochondrial matrix. Complex organelles called mitochondria are crucial for many aspects of cellular function, including metabolism, immune control, and cell death.Calcium buffering, lipid flux, and intracellular signaling are just a few of the many cellular processes and molecular interactions that mitochondria actively participate in. It is becoming more widely acknowledged that mitochondrial dysfunction is a defining feature of many diseases, including cancer, cardiovascular, and neurodegenerative conditions. Mitochondrial metabolism influences processes like the epithelial-to-mesenchymal transition, which is a key factor in the progression of tumors. The epigenetic landscape is altered by mitochondrial metabolism and the oncometabolites that result to change the aggressiveness characteristics of cancer cells. Regarding the survival of tumors in response to treatment, changes in mitochondrial metabolism are important.
|CTPI-2 is a novel, potent, specific, andthird-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM.
|Emapunil (formerlyknown as AC-5216 or XBD-173) isan antianxiolytic drug that also has neuroprotective activities.
|Olesoxime (formerly known as TRO 19622; RG-6083) is a mitochondrial-targeted neuroprotective agent with EC50value for increasing cell survival is 3.2±0.2 µM.