Glucokinase

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate.Humans and the majority of other vertebrates have cells in their liver, pancreas, gut, and brain that contain glucokinase. It functions as a glucose sensor in each of these organs, signaling changes in metabolism or cell function in response to rising or falling blood glucose levels, such as those that happen after meals or during fasting. Since glucosekinase has a lower affinity for glucose than the other hexokinases do and concentrates its activity in a small number of cell types, the other three hexokinases are more crucial glucose preparers for most tissues' and organs' glycolysis and glycogen synthesis.Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.

Glucokinase related products

Cat No.	Product Name	CAS No.	Product Description
V2904	AMG-3969	1361224-53-4	AMG-3969 is a potent, novelandmetabolically stabledisruptor of glucokinase-glucokinase regulatory protein interaction (GK-GKRP) with IC50of 4 nM.
V20192	Dorzagliatin	1191995-00-2	Dorzagliatin (RO-5305552;HMS-5552; sinogliatin)is an investigational antidiabetic agent acting as a dual-acting glucokinase activator(GKA) that is able toimproves glycaemic control and pancreatic β-cell function in type 2 diabete.
V76979	GKA50 quarterhydrate		GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM).
V25611	MK-0941 mesylate	1137916-97-2	MK-0941 mesylate, the mesylate salt ofMK0941, is a novel, orally bioactive and allosteric glucokinase activator (GKA) with anti-diabetic effects.
V78884	Mortatarin F		Mortatarin F (Compound 1) is a glucosidase inhibitor (antagonist) with IC50 of 8.7 μM.
V78908	Mortatarin G		Mortatarin G (compound 3) is a prenylated flavonoid that can be extracted from mulberry leaves.
V4556	PF-04991532	1215197-37-7	PF-04991532 is a novel, potent, hepatoselectiveglucokinaseactivator withEC50of 80 and 100 nM in human and rat, respectively.
V13883	RO 28-1675 (Ro 0281675)	300353-13-3	Ro 28-1675 (Ro-0281675) is a novel, potent and allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM.
V79743	Uvagrandol		Uvagrandol effectively inhibits α-glucosidase and porcine lipase (IC50= 15.2 μM and 11.2 μM, respectively).
V51000	WAY-320081	66780-67-4	glucokinase activator; HSP90 inhibitor
V79295	α-Amylase/α-Glucosidase-IN-3		α-Amylase/α-Glucosidase-IN-3 (Compound 17) is a dual α-Amylase/α-Glucosidase inhibitor (antagonist) with IC50 s of 0.70 μM and 1.10 μM.
V81782	α-Amylase/α-Glucosidase-IN-4		α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual (bifunctional) inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases), with IC50s of 0.15 μM and 1.10 μM respectively.
V81783	α-Amylase/α-Glucosidase-IN-5		α-Amylase/α-Glucosidase-IN-5 (compound 4l) is a dual (bifunctional) inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases), with IC50s of 5.96 μM and 1.62 μM respectively.
V78412	α-Glucosidase-IN-25		α-Glucosidase-IN-25 (Compound (R)-8k) is a competitive inhibitor of α-glucosidase (glucosidase) with IC50 of 1.19 μM and may be utilized in anti-diabetic research.
V79335	α-Glucosidase-IN-26		α-Glucosidase-IN-26 (compound 7i) is an α-glucosidase inhibitor (IC50=4.63 µM) and may be utilized in the study of type 2 diabetes (T2DM).
V79464	α-Glucosidase-IN-27		α-Glucosidase-IN-27 (compound 8l) is an α-glucosidase inhibitor (IC50=25.78 μM).
V79942	α-Glucosidase-IN-30		α-Glucosidase-IN-30 (compound 8c) is a potent, orally bioactive, competitive α-glucosidase inhibitor (antagonist) with a Ki of 40.0 µM and IC50 of 49.0 µM .
V80138	α-Glucosidase-IN-31		α-Glucosidase-IN-31 (compound R1) is an orally bioavailable α-Glucosidase inhibitor (antagonist) with IC50 of 10.1 μM.
V78080	α-Glucosidase-IN-32		α-Glucosidase-IN-32 (compound f26) is a reversible, noncompetitive and orally bioactive α-glucosidase inhibitor (antagonist) with IC50 of 3.07 μM.
V78769	α-Glucosidase-IN-33		α-Glucosidase-IN-33 (compound 7c) is a potent α-glucosidase inhibitor (IC50= 2.39 μM) and may be utilized in the study of type 2 diabetes and hyperglycemia.