White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V31917 | EC330 | 2016795-77-8 | EC330 is a leukemia inhibitory factor (LIF) inhibitor. |
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V21579 | GIBH-130 | 1252608-59-5 | GIBH-130 is a neuroinflammation inhibitor. |
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V12909 | JTE-607 HCl | 188791-09-5 | JTE-607 HCl, the hydrochloride of JTE607, is a potent inhibitor of inflammatory cytokine production with the potential for the treatment of systemic inflammatory response. |
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V26690 | NSC 247030 | 114727-43-4 | SU5201 inhibits interleukin-2 (IL-2) production. |
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V5165 | RP-54745 | 135330-08-4 | RP-54745 (RP 54745) is a novel amino-dithiole-one compound that is active at micromolar concentration on the metabolism of stimulated macrophages, for example, the hexose monophosphate pathway (HMP) and the exocytosis of lysosomal enzymes. |
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V2974 | YM-90709 | 163769-88-8 | YM-90709 is a novel antagonist of interleukin-5 receptor which inhibits the binding of interleukin-5 to interleukin-5 receptor. |
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V1966 | Diacerein (Diacerhein) | 13739-02-1 | Diacerein (Diacerhein; Diacetylrhein) isslow-acting medication which acts asa potent inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, it is indicated for osteoarthritis and chronic inflammatory arthritis. |
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V14140 | Eupafolin | 520-11-6 | Nepetin (6-Methoxyluteolin) is a naturally occurring flavonoid extracted from Eupatorium ballotaefolium HBK and has potent anti~inflammatory activity. |
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V2089 | Suplatast Tosylate (IPD 1151T) | 94055-76-2 | Suplatast Tosilate (also known as IPD-1151T)is a novel capsular anti-asthmatic and anti-allergic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM. |
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V4142 | Apilimod | 541550-19-0 | Apilimod is a novel and potent small molecular inhibitor of IL-12/IL-23 and has been evaluated in clinical trials for patients with Crohns disease or rheumatoid arthritis. |
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V4143 | Apilimod mesylate | 870087-36-8 | Apilimod mesylate, the mesylate salt of Apilimod, is a novel and potent small molecular inhibitor of IL-12/IL-23 and has been evaluated in clinical trials for patients with Crohns disease or rheumatoid arthritis. |
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