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Interleukins

Interleukins

White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.

Interleukins related products

Structure Cat No. Product Name CAS No. Product Description
Apilimod V4142 Apilimod 541550-19-0 Apilimod is a novel and potent small molecular inhibitor of IL-12/IL-23 and has been evaluated in clinical trials for patients with Crohns disease or rheumatoid arthritis.
Apilimod mesylate V4143 Apilimod mesylate 870087-36-8 Apilimod mesylate, the mesylate salt of Apilimod, is a novel and potent small molecular inhibitor of IL-12/IL-23 and has been evaluated in clinical trials for patients with Crohns disease or rheumatoid arthritis.
Diacerein (Diacerhein) V1966 Diacerein (Diacerhein) 13739-02-1 Diacerein (Diacerhein; Diacetylrhein) isslow-acting medication which acts asa potent inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, it is indicated for osteoarthritis and chronic inflammatory arthritis.
EC330 V31917 EC330 2016795-77-8 EC330 is a leukemia inhibitory factor (LIF) inhibitor.
Eupafolin V14140 Eupafolin 520-11-6 Nepetin (6-Methoxyluteolin) is a naturally occurring flavonoid extracted from Eupatorium ballotaefolium HBK and has potent anti~inflammatory activity.
GIBH-130 V21579 GIBH-130 1252608-59-5 GIBH-130 is a neuroinflammation inhibitor.
JTE-607 HCl V12909 JTE-607 HCl 188791-09-5 JTE-607 HCl, the hydrochloride of JTE607, is a potent inhibitor of inflammatory cytokine production with the potential for the treatment of systemic inflammatory response.
NSC 247030 V26690 NSC 247030 114727-43-4 SU5201 inhibits interleukin-2 (IL-2) production.
RP-54745 V5165 RP-54745 135330-08-4 RP-54745 (RP 54745) is a novel amino-dithiole-one compound that is active at micromolar concentration on the metabolism of stimulated macrophages, for example, the hexose monophosphate pathway (HMP) and the exocytosis of lysosomal enzymes.
Suplatast Tosylate (IPD 1151T) V2089 Suplatast Tosylate (IPD 1151T) 94055-76-2 Suplatast Tosilate (also known as IPD-1151T)is a novel capsular anti-asthmatic and anti-allergic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
YM-90709 V2974 YM-90709 163769-88-8 YM-90709 is a novel antagonist of interleukin-5 receptor which inhibits the binding of interleukin-5 to interleukin-5 receptor.
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