PAR

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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PAR

Protease activated receptors (PARs) are a family of G-protein-coupled receptors (GPCRs) that are irreversibly activated by proteolytic cleavage of the N terminus, which unmasks a tethered peptide ligand that binds and activates the transmembrane receptor domain, eliciting a cellular cascade in response to inflammatory signals and other stimuli. There are four members of the PAR family: PAR1, PAR2, PAR3 and PAR4. PARs have important functions in the vasculature, inflammation, and cancer and are important drug targets.The PAR family consists of four members: PAR1, PAR2, PAR3, and PAR4. PARs are significant targets for pharmaceuticals and have vital roles in the vasculature, inflammation, and cancer.

With the exception of red blood cells, PARs are expressed on almost all blood and blood vessel wall cell types (ECs, fibroblasts, myocytes), as well as on platelets, neutrophils, macrophages, and leukemic white blood cells. Immune cells, astrocytes, neurons, and epithelium all express thrombin-activated PAR-1, PAR-3, and PAR-4. Human vascular, intestinal, neuronal, and airway cells contain PAR-2, which is activated by serine proteases similar to trypsin. Its expression rises in tissues that have been injured or in response to inflammatory mediator stimulation.

PAR related products

Cat No.	Product Name	CAS No.	Product Description
V74499	2-Furoyl-LIGRLO-amide	729589-58-6	2-Furoyl-LIGRLO-amide is a potent and specific protease-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0.
V74504	2-Furoyl-LIGRLO-amide TFA	2468029-34-5	2-Furoyl-LIGRLO-amide TFA is a potent and specific protease-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0.
V2850	AC 55541	916170-19-9	AC-55541 is anagonist of protease-activated receptor (PAR) 2.
V71929	Aeruginosin 98-B	167228-01-5	Aeruginosin 98-B is a protease inhibitor.
V74510	Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2	211190-38-4	Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide.
V74516	AY254	2093408-03-6	AY254 is an analogue of AY77.
V74515	AY77	1835734-92-3	AY77 is a calcium-biased PAR2 agonist.
V31712	AZ3451	2100284-59-9	AZ3451 is a protease-activated receptor-2 (PAR2) antagonist (inhibitor) with IC50 of 23 nM.
V3483	BMS-986120	1478712-37-6	BMS-986120 (BMS986120) is a novel, potent and orally bioactive antagonist of protease-activated receptor-4 (PAR4) with the potential to be used forthrombus propagation and pathological vascular occlusion.
V51013	CL-417513	313986-65-1	PAR2 inhibitor
V74514	FR-171113	173904-50-2	FR171113 is a specific non-peptide thrombin receptor antagonist.
V74501	FSLLRY-NH2	245329-02-6	FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor.
V76998	FSLLRY-NH2 TFA		FSLLRY-NH2 TFA is a protease-activated receptor 2 (PAR2) inhibitor.
V76986	GB-110 hydrochloride		GB-110 HCl is a potent, orally bioactive, non-peptide protease activated receptor 2 (PAR2) agonist.
V25156	I-191	1690172-25-8	I-191 is a potent antagonist of protease-activated receptor 2 (PAR2).
V69828	I-287	2014368-93-3	I-287 is an orally bioactive and selective inhibitor of PAR2 that negatively regulates Gαq and Gα12/13 activities and their downstream effectors.
V2419	ML161 (Parmodulin 2)	423735-93-7	ML-161 is a novel and potent allosteric inhibitor of PAR1 (proteinase-activated receptor 1) on platelets with IC50 of 0.26 μM.
V74512	P4pal10	1021346-05-3	P4pal10 is a PAR4 antagonist.
V100438	P4pal10 TFA		P4pal10 TFA is the TFA salt form of P4pal10.
V86749	PAR 4 (1-6) (human)	225779-44-2	PAR 4 (1-6) TFA (GYPGQV TFA) is a hexapeptide that is a fragment of the protease-activated receptor 4 (PAR4) and acts as a PAR4-specific agonist.