yingweiwo
  1. Home
  2. Products
  3. Signaling Pathways
  4. GPCR & G Protein
  5. PAR

PAR

PAR

Protease activated receptors (PARs) are a family of G-protein-coupled receptors (GPCRs) that are irreversibly activated by proteolytic cleavage of the N terminus, which unmasks a tethered peptide ligand that binds and activates the transmembrane receptor domain, eliciting a cellular cascade in response to inflammatory signals and other stimuli. There are four members of the PAR family: PAR1, PAR2, PAR3 and PAR4. PARs have important functions in the vasculature, inflammation, and cancer and are important drug targets.The PAR family consists of four members: PAR1, PAR2, PAR3, and PAR4. PARs are significant targets for pharmaceuticals and have vital roles in the vasculature, inflammation, and cancer.

With the exception of red blood cells, PARs are expressed on almost all blood and blood vessel wall cell types (ECs, fibroblasts, myocytes), as well as on platelets, neutrophils, macrophages, and leukemic white blood cells. Immune cells, astrocytes, neurons, and epithelium all express thrombin-activated PAR-1, PAR-3, and PAR-4. Human vascular, intestinal, neuronal, and airway cells contain PAR-2, which is activated by serine proteases similar to trypsin. Its expression rises in tissues that have been injured or in response to inflammatory mediator stimulation.

PAR related products

Structure Cat No. Product Name CAS No. Product Description
(R)-AZ8838 V112324 (R)-AZ8838 2151021-59-7 (R)-AZ8838 is a competitive PAR2 antagonist with a pKi value of 5.2 for human PAR2.
(Rac)-AZ8838 V122002 (Rac)-AZ8838 2100283-63-2 (Rac)-AZ8838 is a conformational antagonist of protease-activated receptor 2 (PAR2) and can be used to study pain and inflammation-related diseases.
1-Methyladenosine-d3 V123612 1-Methyladenosine-d3 1-Methyladenosine-d3 is a deuterium-labeled 1-methyladenosine.
15-Deoxy-Δ12,14-Prostaglandin J2-2-glyceryl ester V123232 15-Deoxy-Δ12,14-Prostaglandin J2-2-glyceryl ester 1947405-90-4 15-Deoxy-Δ12,14-Prostaglandin J2-2-glyceryl ester is a derivative of 15-deoxy-Δ-12,14-prostaglandin J2.
15-LOX-IN-2 V123253 15-LOX-IN-2 15-LOX-IN-2 is an orally effective COX-2/15-LOX inhibitor and a partial agonist of PPARγ.
2-Furoyl-LIGRLO-amide V74499 2-Furoyl-LIGRLO-amide 729589-58-6 2-Furoyl-LIGRLO-amide is a potent and specific protease-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0.
2-Furoyl-LIGRLO-amide TFA V74504 2-Furoyl-LIGRLO-amide TFA 2468029-34-5 2-Furoyl-LIGRLO-amide TFA is a potent and specific protease-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0.
5-cis Carbaprostacyclin V126937 5-cis Carbaprostacyclin 69609-77-4 5-cis Carbaprostacyclin is a PGI2-stable analog based on carbaprostacyclin.
ABP/PPAR modulator 1 V128046 ABP/PPAR modulator 1 3104894-76-7 ABP/PPAR modulator 1 is an orally effective multimodal regulator of FABP and PPAR (IC50 for FABP1 and FABP4 are 0.65 μM and 1.08 μM, respectively, and EC50 for PPARα, PPARγ and PPARδ are 9.19 μM, 2.20 μM and 1.58 μM, respectively).
AC 55541 V2850 AC 55541 916170-19-9 AC-55541 is anagonist of protease-activated receptor (PAR) 2.
Aeruginosin 98-B V71929 Aeruginosin 98-B 167228-01-5 Aeruginosin 98-B is a protease inhibitor.
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 V74510 Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 211190-38-4 Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide.
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA V118411 Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA is a bioactive peptide and a selective protease receptor 1 (PAR-1) agonist, with higher specificity for PAR-1 than for PAR-2.
AY254 V74516 AY254 2093408-03-6 AY254 is an analogue of AY77.
AY77 V74515 AY77 1835734-92-3 AY77 is a calcium-biased PAR2 agonist.
AZ3451 V31712 AZ3451 2100284-59-9 AZ3451 is a protease-activated receptor-2 (PAR2) antagonist (inhibitor) with IC50 of 23 nM.
BMS-986120 V3483 BMS-986120 1478712-37-6 BMS-986120 (BMS986120) is a novel, potent and orally bioactive antagonist of protease-activated receptor-4 (PAR4) with the potential to be used forthrombus propagation and pathological vascular occlusion.
CL-417513 V51013 CL-417513 313986-65-1 PAR2 inhibitor
CS4 V132506 CS4 CS4 is a selective HDAC inhibitor with IC50 values of 38 nM, 12 nM, 5.8 μM, 19 μM, and 61 μM for HDAC1, HDAC6, HDAC8, HDAC4, and HDAC11, respectively.
CUDA disodium V132549 CUDA disodium CUDA disodium is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50 values of 11.1 nM for mouse sEH and 112 nM for human sEH.
Contact Us
Tel: 1-708-310-1919 Fax: 1-708-557-7486 Email: [email protected] Frequently Asked Questions
Subscribe to our E-newsletter
Name
E-mail

Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved

linkedin facebook
Contact Us
Home Product Cart Member