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Sodium Channel

Sodium Channel

Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.

Sodium Channel related products

Structure Cat No. Product Name CAS No. Product Description
(R)-Funapide ((R)-TV 45070; (R)-XEN402) V73671 (R)-Funapide ((R)-TV 45070; (R)-XEN402) 1259933-15-7 (R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide.
3'-Methoxydaidzein (3'-methoxydaidzein) V73709 3'-Methoxydaidzein (3'-methoxydaidzein) 21913-98-4 3'-Methoxydaidzein is an isoflavone and Sodium Channel inhibitor.
4,9-Anhydrotetrodotoxin (Anhydroepitetrodotoxin) V73675 4,9-Anhydrotetrodotoxin (Anhydroepitetrodotoxin) 13072-89-4 4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in the human brain and induces voltage-dependent inactivation of Nav1.6 Hyperpolarization shift.
4-Chlorophenylguanidine hydrochloride V73694 4-Chlorophenylguanidine hydrochloride 14279-91-5 4-Chlorophenylguanidine HCl is a potent ASIC3-PAM (positive allosteric modulator) that reverses ASIC3 desensitization.
5-(N,N-Hexamethylene)-amiloride V32884 5-(N,N-Hexamethylene)-amiloride 1428-95-1 5-(N,N)-Dimethylamiloride Hydrochloride(Hexamethylene amiloride), anamiloride derivative, is a Na(+)-H+ exchange inhibitor thatdecreases the intracellular pH (pHi) and induces apoptosis inleukemic cells.
6-Benzoylheteratisine V85042 6-Benzoylheteratisine 99759-48-5
6-Iodoamiloride V73708 6-Iodoamiloride 60398-23-4 6-Iodoamiloride is a potent acid-sensitive ion channel 1 (ASIC1) inhibitor (antagonist) with IC50 of 88 nM.
A-317491 sodium salt hydrate V77310 A-317491 sodium salt hydrate A-317491 sodium salt hydrate is a specific and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22 for hP2X3, rP2X3, hP2X2/3 and rP2X2/3, respectively.
A-803467 V1649 A-803467 944261-79-4 A-803467 (A803467;A 803467) is a novel, potent and selective NaV1.8 sodium channel blocker with potential analgesic effects.
Aah II V77710 Aah II Aah II is a sodium channel modulator.
Ajmaline V10593 Ajmaline 4360-12-7 Ajmaline (also known as Gilurytmal and Ritmos) is a natual alkaloid and a sodium channel blocker.
Ambroxol HCl (NA-872) V1661 Ambroxol HCl (NA-872) 23828-92-4 Ambroxol HCl (formerlyNA872; NA 872; Abrohexal;Ebromin;Ambril; Ambro-Puren Ambrobeta;Duramucal; Mucosolvan),the hydrochloride salt of ambroxol, is a secretolytic agent that has been used in the treatment of respiratory diseases associated with viscid or excessive mucus.
Amiloride HCl (MK-870) V1644 Amiloride HCl (MK-870) 2016-88-8 Amiloride HCl (MK-870; Midamor; Midoride; Modamide),the hydrochloride salt of amiloride, is a potent and relatively selective inhibitor of the epithelial sodium channel (ENaC) with anti-hypertensive activity.
Amiloride HCl dihydrate (MK 870) V1652 Amiloride HCl dihydrate (MK 870) 17440-83-4 Amiloride HCl dihydrate (MK870; MK-870; MK 870;Midamor; Midoride; Modamide),the hydrochloride salt and dihydrated form of amiloride, is a potent andselective epithelial sodium channel (ENaC) blocker that has been used since 1967 in the management of hypertension and congestive heart failure.
Analgesic agent-2 V77943 Analgesic agent-2 Analgesic agent-2 is a selective and active NaV1.8 Channel inhibitor (antagonist) with IC50 of 50.18 nM in stably expressing human HEK293 cells.
Ancistrotecine B V78685 Ancistrotecine B Ancistrotecine B (Compound 2) is a Nav1.7 channel inhibitor (IC50= 0.73 μM).
Aneratrigine V73724 Anaratrigine 2097163-74-9 Aneratrigine is a sodium channel protein type 9 subunit blocker.
Aneratrigine hydrochloride V73691 Anaratrigine hydrochloride 2097163-75-0 Aneratrigine ( HCl) is a sodium channel protein type 9 subunit blocker.
Anthopleurin-C V77960 Anthopleurin-C Anthopleurin-C (APE 2-1) is a cardiotonic peptide with potent positive inotropic effects.
APETx2 V73677 APETx2 713544-47-9 APETx2 is a sea anemone peptide extracted from Anthopleura elegantissima.
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