Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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![(5R)-5-(4-{[(2-氟苯基)甲基]氧基}苯基)-L-脯氨酰胺](http://www.invivochem.com/upload/1124/V3620.png)
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V3620 | Raxatrigine | 934240-30-9 | Raxatrigine (also known as GSK1014802 and CNV-1014802) is a novel, potent small molecule state-dependent sodium channel blocker, the Nav1.7 sodium channel inhibitor. |
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V73671 | (R)-Funapide ((R)-TV 45070; (R)-XEN402) | 1259933-15-7 | (R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide. |
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V73709 | 3'-Methoxydaidzein (3'-methoxydaidzein) | 21913-98-4 | 3'-Methoxydaidzein is an isoflavone and Sodium Channel inhibitor. |
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V73675 | 4,9-Anhydrotetrodotoxin (Anhydroepitetrodotoxin) | 13072-89-4 | 4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in the human brain and induces voltage-dependent inactivation of Nav1.6 Hyperpolarization shift. |
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V73694 | 4-Chlorophenylguanidine hydrochloride | 14279-91-5 | 4-Chlorophenylguanidine HCl is a potent ASIC3-PAM (positive allosteric modulator) that reverses ASIC3 desensitization. |
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V1654 | Phenytoin (5,5-Diphenylhydantoin) | 57-41-0 | Phenytoin (also known as NCI-C55765; NCI C55765; NCIC55765; Diphenylhydantoin)is an inactive voltage-gated sodium channel stabilizer that has been approved as an anticonvulsant for the treatment of seizures. |
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V32884 | 5-(N,N-Hexamethylene)-amiloride | 1428-95-1 | 5-(N,N)-Dimethylamiloride Hydrochloride(Hexamethylene amiloride), anamiloride derivative, is a Na(+)-H+ exchange inhibitor thatdecreases the intracellular pH (pHi) and induces apoptosis inleukemic cells. |
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V85042 | 6-Benzoylheteratisine | 99759-48-5 | |
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V73708 | 6-Iodoamiloride | 60398-23-4 | 6-Iodoamiloride is a potent acid-sensitive ion channel 1 (ASIC1) inhibitor (antagonist) with IC50 of 88 nM. |
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V77310 | A-317491 sodium salt hydrate | A-317491 sodium salt hydrate is a specific and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22 for hP2X3, rP2X3, hP2X2/3 and rP2X2/3, respectively. | |
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V1649 | A-803467 | 944261-79-4 | A-803467 (A803467;A 803467) is a novel, potent and selective NaV1.8 sodium channel blocker with potential analgesic effects. |
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V77710 | Aah II | Aah II is a sodium channel modulator. | |
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V77943 | Analgesic agent-2 | 2983892-65-3 | Analgesic agent-2 is a selective and active NaV1.8 Channel inhibitor (antagonist) with IC50 of 50.18 nM in stably expressing human HEK293 cells. |
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V78685 | Ancistrotecine B | Ancistrotecine B (Compound 2) is a Nav1.7 channel inhibitor (IC50= 0.73 μM). | |
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V73724 | Anaratrigine | 2097163-74-9 | Aneratrigine is a sodium channel protein type 9 subunit blocker. |
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V73691 | Anaratrigine hydrochloride | 2097163-75-0 | Aneratrigine ( HCl) is a sodium channel protein type 9 subunit blocker. |
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V87238 | Anthopleurin-A | Anthopleurin-A is a sodium channel toxin. | |
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V87231 | Anthopleurin-A TFA | Anthopleurin-A TFA is a sodium channel toxin. | |
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V77960 | Anthopleurin-C | Anthopleurin-C (APE 2-1) is a cardiotonic peptide with potent positive inotropic effects. | |
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V73677 | APETx2 | 713544-47-9 | APETx2 is a sea anemone peptide extracted from Anthopleura elegantissima. |
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