A highly conserved eukaryotic Ca2+ sensor protein is calmodulin (CaM), a member of the superfamily of EF-hand proteins. Different mechanisms cause brief increases in intracellular Ca2+ concentrations in response to cellular stimulation, which start various protein activities. Since most proteins lack Ca2+ binding sites, a mediator is needed to react to this cation.Calmodulin is the most significant Ca2+ signal transducer in eukaryotic cells due to its capacity to transmit conformational changes to a broad and diverse array of proteins in response to Ca2+ oscillations, coordinating the activity of hundreds of proteins. The Ca2+/calmodulin complex is created when Ca2+ binds to calmodulin and interacts with other proteins in the cell. These proteins function as enzymes and effectors in numerous physiological and cellular processes. Additionally, processes can be directly regulated by the Ca2+/calmodulin complex.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74256 | A-7 hydrochloride (Ophobolin A) | 79127-24-5 | A-7 HCl (Ophobolin A) is a calmodulin antagonist used in cancer-related research. |
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V74257 | Calmodulin antagonist-1 | 78957-84-3 | Calmodulin antagonist-1 (A-5) is a calmodulin (CaM) antagonist. |
|
V74258 | CALP2 | 261969-04-4 | CALP2 is a calmodulin (CaM) antagonist (Kd 7.9 µM) that binds with affinity to the CaM EF-hand/Ca2+ binding site. |
|
V77167 | CALP2 TFA | CALP2 TFA is a calmodulin (CaM) antagonist (Kd 7.9 µM) that binds with affinity to the CaM EF-hand/Ca2+ binding site. | |
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V74255 | Encecalinol | 88728-56-7 | Encecalinol is found in the aerial part of the plant Ageratina grandifolia and is a potent inhibitor of calmodulin inhibitors. |
|
V80933 | Neurogranin (48-76), mouse | Neurogranin (48-76), mouse is a polypeptide corresponding to residues 48-76 of Neurogranin. | |
|
V5660 | W-9 HCL | 69762-85-2 | W-9 hydrochlorideis a novel and potent Calmodulin antagonist. |
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