Retinoic acid receptor-related orphan receptors (RORs) are a subfamily of the thyroid hormone receptor, which is a subfamily of the nuclear receptors and a member of the orphan nuclear receptor family. ROR (NR1F1), ROR (NR1F2), and ROR (NR1F3) are three members of the ROR subfamily that act as ligand-dependent transcription factors.
According to reports, RORs play a role in the development of secondary lymphoid tissues, autoimmune and inflammatory diseases, the circadian rhythm, and metabolism homeostasis. They are also thought to activate transcription through ligand-dependent interactions with co-regulators.
Important immune system regulators include ROR and ROR. These elements are necessary for the growth and differentiation of Th17 cells. Inflammation and autoimmune disease are facilitated by ROR, which is expressed in lymphoid tissue inducer cells, innate lymphoid cells, invariant natural killer T cells, and T cells.
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