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ROR

ROR

Retinoic acid receptor-related orphan receptors (RORs) are a subfamily of the thyroid hormone receptor, which is a subfamily of the nuclear receptors and a member of the orphan nuclear receptor family. ROR (NR1F1), ROR (NR1F2), and ROR (NR1F3) are three members of the ROR subfamily that act as ligand-dependent transcription factors.
According to reports, RORs play a role in the development of secondary lymphoid tissues, autoimmune and inflammatory diseases, the circadian rhythm, and metabolism homeostasis. They are also thought to activate transcription through ligand-dependent interactions with co-regulators.

Important immune system regulators include ROR and ROR. These elements are necessary for the growth and differentiation of Th17 cells. Inflammation and autoimmune disease are facilitated by ROR, which is expressed in lymphoid tissue inducer cells, innate lymphoid cells, invariant natural killer T cells, and T cells.

ROR related products

Structure Cat No. Product Name CAS No. Product Description
Cedirogant V3130 Cedirogant 2055496-11-0 Cedirogant (also known as ABBV-157) is a novel and orally active RORγt inverse agonist.
Cintirorgon (LYC-55716) V3253 Cintirorgon (LYC-55716) 2055536-64-4 Cintirorgon (formerly also known as LYC55716; LYC-55716), a novel and potent immune modulatory medicine developed by Lycera, is a synthetic and orally bioavailable small molecule agonist of RAR-related orphan receptor γ (RORγ).
S18-000003 V14191 S18-000003 2068119-11-7 S18-000003 is a novel, potent andorally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor with the potential to beused for psoriasis with low risk of thymic aberrations.
SR-0987 V15216 SR-0987 303126-97-8 SR-0987 is a T cell-specific RORγ (RORγt) agonist.
SR-1078 V15217 SR-1078 1246525-60-9 SR-1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 µM without effect at the related liver X receptors and farnesoid X receptors.
SR3335 V4025 SR3335 293753-05-6 SR3335 (also known as ML-176)is a novel and selective RORα inverse agonistwith aKiof 220 nM.
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