PKA

PKA

The -phosphate group of ATP is transferred to protein substrates by the Ser/Thr phosphoryl transferase known as PKA. More than 100 membrane- and cytoplasmic-associated targets are phosphorylated by PKA. PKA mediates a wide range of cellular signaling activities, and its activity is strictly controlled in both time and space.

The hedgehog (Hh) signal transduction pathway is negatively regulated by PKA, an evolutionary conserved protein. The proteolytic processing step that results in the repressor forms of the Ci and Gli transcription factors, which turn off target genes in the absence of Hh, is known to require PKA.

PKA related products

Structure Cat No. Product Name CAS No. Product Description
V69112 6-Bnz-cAMP sodium salt 1135306-29-4
V1847 8-Bromo-cAMP 76939-46-3 8-Bromo-cAMP is a potent and cell permeable cyclic AMP (cAMP) analog and a PKA activator.
V78101 Aplithianines A
V78154 ATP Synthesis-IN-3
V69118 BLU0588 2810747-78-3
V4272 Bucladesine calcium (DC2797) 938448-87-4 Bucladesine calcium (Dibutyryl-cAMP calcium; DC2797 calcium salt) is a cell-permeable PKA activator/agonist and a cAMP analog that mimics the action of endogenous cAMP.
V2841 CCG215022 1813527-81-9 CCG215022 is a potent GRK2 and GRK5 inhibitor that exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA.
V69124 Cys-Kemptide 309247-46-9
V1846 Dibutyryl-cAMP (Bucladesine sodium) 16980-89-5 Bucladesine sodium (also known as Dibutyryl-cAMP sodium), the sodium salt ofBucladesine, is a cell-permeable PKA activator and a cAMP analog that mimics the action of endogenous cAMP.
V69111 DS89002333 2832159-79-0
V69106 GEM-231 (HYBO-165) 255810-66-3
V79571 GEM-231 sodium (HYBO-165 sodium)
V16050 H-89 free base 127243-85-0 H-89 is a specific adenylyl cyclase inhibitor (DDA) and a cyclic AMP-dependent protein kinase inhibitor.
V31529 Jaspamycin 22242-96-2 Jaspamycin(7-CN-7-C-Ino) is a naturally occuring metaboliteisolated from the marine sponge Jaspis splendens with anti-parasiteactivity.
V80487 Kemptide Phospho-Ser5 (Kemptide (Phospho-Ser5))
V69119 PKA Inhibitor Fragment (6-22) amide (PKI-(6-22)-amide) 121932-06-7
V76627 PKA Inhibitor Fragment (6-22) amide TFA (PKI-(6-22)-amide TFA)
V69109 PKA-IN-1 179985-52-5
V69113 PKI (14-24)amide TFA 1293946-39-0
V69120 PKI (5-24),amide (IP20-amide) 100891-36-9
Contact Us