Thioredoxin Reductase

Thioredoxin Reductase

Thioredoxin reductase (TrxR) is a pyridine nucleotide-disulphide oxidoreductase that contains selenium. Mammalian TrxRs come in three different isoforms: TrxR1 (TXRND1), TrxR2 (TXNRD2), and TrxR3 (TGR). Thioredoxin (Trx), a redox protein, is reduced by NADPH in a NADPH-dependent manner thanks to TrxRs. TrxR plays a crucial role in controlling the intracellular redox environment, cell division and growth, and the recycling of ascorbate from its oxidized state. Cancers, metabolic syndrome, insulin resistance, type 2 diabetes, hypertension, and atherosclerosis are all linked to the Trx/TrxR system.

Thioredoxin Reductase related products

Structure Cat No. Product Name CAS No. Product Description
V4270 TRi-1 246020-68-8 TRi-1 (also know nas TXNRD1 inhibitor 1) is a novel, potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1) with anticancer potential activity.
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