The host's innate immune system and immune homeostasis depend heavily on the cytoplasmic pattern-recognition receptors (PRRs) known as nucleotide oligomerization domain (NOD)-like receptors (NLRs). Humans have 23 members of the NLR family, while mice have at least 34 NLR genes. Although many cell types, including immune and epithelial cells, express NLRs, some NLR family members, such as macrophages and neutrophils, express them primarily in phagocytes. The NLR family is most frequently divided into one of four subfamilies based on their N-terminal domains: NLRA, NLRB, NLRC, and NLRP.
The NLRs are capable of recognizing a wide range of ligands, including those produced by microbial pathogens (peptidoglycan, flagellin, viral RNA, fungal hyphae, etc.), host cells (ATPs, cholesterol crystals, uric acid, etc.), and environmental sources (alum, asbestos, silica, alloy particles, UV radiation, skin irritants, etc.). Most NLRs function as PRRs, identifying the aforementioned ligands and inciting inflammatory reactions. Some NLRs, however, might not function as PRRs and instead react to cytokines like interferons. Four broad categories of functions performed by the activated NLRs include inflammasome formation, signal transduction, transcription activation, and autophagy.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V86923 | (S)-NDT-19795 | (S)-NDT-19795 is an effective NLRP3 inflammasome inhibitor. | |
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V75164 | (±)11(12)-EET (11,12-EET) | 123931-40-8 | (±)11(12)-EET is an inhibitor (blocker/antagonist) of the NLRP3 inflammasome. |
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V75174 | (±)11(12)-EET-d11 ((±)11,12-EET-d11) | 2699607-19-5 | (±)11(12)-EET-d11 is the deuterated form of (±)11(12)-EET. |
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V75186 | ADS032 | 2757333-37-0 | ADS032 is a dual (bifunctional) inhibitor of NLRP1 and NLRP3 that can rapidly, reversibly and stably inhibit inflammasome formation. |
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V85252 | Aluminum phosphate adjuvant | ||
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V85365 | Aluminum phosphate adjuvant (GMP) | ||
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V86928 | BAL-0028 | 2842012-69-3 | BAL-0028 (Compound 3) is an inhibitor of NLRP3 activation with an IC50 of 25 nM. |
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V85981 | Callicarboric acid A | ||
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V83500 | COX-2/NLRP3-IN-1 | ||
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V85526 | CSC-6 | ||
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V86915 | CVN293 | 2815296-08-1 | CVN293 is a selective, blood-brain barrier-permeable potassium (K+) channel KCNK13 inhibitor with IC50 values of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. |
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V74293 | D359-0396 | 1031977-31-7 | D359-0396 is an orally bioactive NLRP3 inflammasome inhibitor. |
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V75166 | Emlenoflast (MCC7840) | 1995067-59-8 | Emlenoflast (MCC7840), a sulfonylurea, is a potent and specific inhibitor of the NLRP3 inflammasome with IC50 of less than 100 nM. |
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V75161 | GSK717 | 1595278-21-9 | GSK717 is a potent and specific NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. |
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V80371 | INF200 | INF200 (compound 5) is a sulfonylurea-based inhibitor that can suppress NLRP3 and NLRP3-mediated pyroptosis. | |
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V2031 | INF39 | 866028-26-4 | INF39 (INF-39; INF 39), an acrylate derivative, is a potent, irreversible andnontoxic inhibitor of NLRP3 with potential anti-inflammatory activity. |
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V51067 | JC2-11 | 937820-89-8 | inhibitor of inflammatory corpuscles |
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V79924 | JT001 sodium (NLRP3-IN-19 sodium) | 2238820-09-0 | JT001 (NLRP3-IN-19) sodium is a potent, specific and orally bioactive NLRP3 inhibitor. |
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V75180 | JT002 | 2238820-43-2 | JT002 is an orally bioactive NLRP3 inflammasome inhibitor. |
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V75181 | M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) | 60230-21-9 | M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a biologically active peptide. |
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