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BACE

BACE

Amyloid precursor protein (APP) is broken down by beta-secretase (BACE), a transmembrane aspartic proteinase, to produce the soluble ectodomain (sAPPbeta) and its C-terminal fragment (CTFbeta). Therapeutics for Alzheimer's disease (AD) frequently target BACE. The enzyme comes in two different varieties: BACE1 and BACE2.
The hallmark neuropathology of Alzheimer's disease (AD) is the deposition of amyloid-protein (A) to produce neuritic plaques. By cleavages caused by - and -secretases, A is produced from APP. The -secretase BACE1 causes severe side effects when inhibited, whereas BACE2 suppresses A normally by cleaving APP/A at the -site (Phe20) in the A domain.

BACE related products

Structure Cat No. Product Name CAS No. Product Description
AZD3839 V1314 AZD3839 1227163-84-9 AZD3839 (AZD-3839; AZD 3839) is a novel, potent and selective BACE1 (β-secretase) inhibitor with the potential for the treatment of Alzheimer disease.
Lanabecestat V2701 AZD3293 (Lanabecestat) 1383982-64-6 Lanabecestat (formerly AZD-3293; LY-3314814; AZD3293; LY3314814) is a novel potent, orally bioactive, highly permeable,brain-penetreable inhibitor of beta-secretase 1 cleaving enzyme (BACE) with aKiof 0.4 nM.
LY2886721 V1312 LY2886721 1262036-50-9 LY2886721 (LY 2886721; LY-2886721) is a novel, potent and selective BACE (β-secretase) inhibitor with the potential for the treatment of AD-Alzheimers Disease.
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