|
V70630
|
(1S,3R)-ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid)
|
111900-32-4 |
(1S,3R)-ACPD is an mGluR agonist that depolarizes pyramidal cells. |
|
V86669
|
(2R,4R)-APDC hydrate
|
|
(2R,4R)-APDC hydrate ((2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid hydrate) is a group II metabotropic glutamate receptor (mGluR) agonist. |
|
V70632
|
(rel)-Eglumegad ((rel)-LY354740; (rel)-Eglumetad)
|
176027-90-0 |
(rel)-Eglumegad ((rel)-LY354740) is the racemic isomer of Eglumegad. |
|
V70637
|
(S)-3-Hydroxyphenylglycine ((S)-3HPG)
|
71301-82-1 |
(S)-3-Hydroxyphenylglycine ((S)-3HPG) is a potent mGluR1 agonist without effect at mGlu2 or mGlu4. |
|
V70639
|
(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine)
|
85148-82-9 |
(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of mGluR2. |
|
V70635
|
(S,S)-BMS-984923
|
1375752-77-4 |
(S,S)-BMS-984923 is the less active (S,S)-enantiomer of BMS-984923. |
|
V70636
|
(±)-LY367385
|
198419-90-8 |
(±)-LY367385 is the racemate of LY367385. |
|
V70629
|
(±)-LY395756
|
852679-66-4 |
(±)-LY395756 is an agonist of mGlu2 receptor and an antagonist of mGlu3 receptor. |
|
V3335
|
(RS)-MCPG
|
146669-29-6 |
RS)-a-Methyl-4-carboxyphenylglycine [(RS)-MCPG] is a group I and II mGluR (metabotropic glutamate receptor) antagonist, it blocked TBS-induced shifts in both juvenile and neonatal hippocampal neurons. |
|
V70633
|
3,3'-Difluorobenzaldazine (DFB)
|
15332-10-2 |
3,3'-Difluorobenzaldazine (DFB) is a selective mGluR5 PAM (positive allosteric modulator). |
|
V70634
|
ACPT-II
|
195209-04-2 |
ACPT-II is an agonist of group III mGluRs with diverse biological effects like neuro-protective (neuro-protection), anticonvulsant (antiepileptic/antiseizure), and anxiolytic (anti-anxiety)-like effects. |
|
V70619
|
AMN082 free base
|
83027-13-8 |
AMN082 free base is a selective, orally bioactive, BBB (blood-brain barrier) permeable (penetrable) mGluR7 agonist that directly activates receptor signaling through the allosteric site in the transmembrane region. |
|
V86672
|
AZ12559322
|
947184-66-9 |
AZ12559322 is a positive allosteric modulator of mGluR2 with a Ki value of 1.31 nM. |
|
V77221
|
AZD 2066 hydrate
|
|
AZD 2066 hydrate is a selective, orally bioactive and BBB (blood-brain barrier) permeable/penetrable mGluR5 antagonist. |
|
V4247
|
AZD-8529
|
1092453-15-0 |
AZD-8529 is a novel, potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 (group II metabotropic glutamate receptors) with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. |
|
V4351
|
AZD-9272
|
327056-26-8 |
AZD-9272 is a potent, selective, orally bioavailable and brain penetrant antagonist mGlu5 (metabotropic glutamate receptor 5) with IC50 values of 2.6 and 7.6 nM for rat and human receptors, respectively. |
|
V12295
|
Basimglurant sulfate (RG 7090; RO 491752)
|
802906-73-6 |
Basimglurant sulfate (RG7090; RO491752) is a potent, selective and orally bioavailable mGlu5 negative allosteric modulator with a Kd of 1.1 nM. |
|
V70615
|
BMS-984923
|
1375752-78-5 |
BMS-984923 is a potent mGluR5 silent isomeric modulator with good affinity (Ki = 0.6 nM), good oral bioavailability (F) and BBB (blood-brain barrier) permeability. |
|
V85068
|
CBiPES
|
353235-01-5 |
|
|
V3355
|
CFMTI
|
864864-17-5 |
CFMTI is a novel, potent and selective allosteric antagonist of metabotropic glutamate receptor (mGluR) 1 with IC50 of 2.6 nM. |