| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70630 | (1S,3R)-ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid) | 111900-32-4 | (1S,3R)-ACPD is an mGluR agonist that depolarizes pyramidal cells. |
|
V70632 | (rel)-Eglumegad ((rel)-LY354740; (rel)-Eglumetad) | 176027-90-0 | (rel)-Eglumegad ((rel)-LY354740) is the racemic isomer of Eglumegad. |
|
V3335 | (RS)-MCPG | 146669-29-6 | RS)-a-Methyl-4-carboxyphenylglycine [(RS)-MCPG] is a group I and II mGluR (metabotropic glutamate receptor) antagonist, it blocked TBS-induced shifts in both juvenile and neonatal hippocampal neurons. |
|
V70637 | (S)-3-Hydroxyphenylglycine ((S)-3HPG) | 71301-82-1 | (S)-3-Hydroxyphenylglycine ((S)-3HPG) is a potent mGluR1 agonist without effect at mGlu2 or mGlu4. |
|
V70639 | (S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) | 85148-82-9 | (S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of mGluR2. |
|
V70635 | (S,S)-BMS-984923 | 1375752-77-4 | (S,S)-BMS-984923 is the less active (S,S)-enantiomer of BMS-984923. |
|
V70636 | (±)-LY367385 | 198419-90-8 | (±)-LY367385 is the racemate of LY367385. |
|
V70629 | (±)-LY395756 | 852679-66-4 | (±)-LY395756 is an agonist of mGlu2 receptor and an antagonist of mGlu3 receptor. |
|
V70633 | 3,3'-Difluorobenzaldazine (DFB) | 15332-10-2 | 3,3'-Difluorobenzaldazine (DFB) is a selective mGluR5 PAM (positive allosteric modulator). |
|
V70634 | ACPT-II | 195209-04-2 | ACPT-II is an agonist of group III mGluRs with diverse biological effects like neuro-protective (neuro-protection), anticonvulsant (antiepileptic/antiseizure), and anxiolytic (anti-anxiety)-like effects. |
|
V70619 | AMN082 free base | 83027-13-8 | AMN082 free base is a selective, orally bioactive, BBB (blood-brain barrier) permeable (penetrable) mGluR7 agonist that directly activates receptor signaling through the allosteric site in the transmembrane region. |
|
V77221 | AZD 2066 hydrate | AZD 2066 hydrate is a selective, orally bioactive and BBB (blood-brain barrier) permeable/penetrable mGluR5 antagonist. | |
|
V4247 | AZD-8529 | 1092453-15-0 | AZD-8529 is a novel, potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 (group II metabotropic glutamate receptors) with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. |
|
V4248 | AZD-8529 mesylate | 1314217-69-0 | AZD-8529 mesylate is a novel, potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 (group II metabotropic glutamate receptors) with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. |
|
V4351 | AZD-9272 | 327056-26-8 | AZD-9272 is a potent, selective, orally bioavailable and brain penetrant antagonist mGlu5 (metabotropic glutamate receptor 5) with IC50 values of 2.6 and 7.6 nM for rat and human receptors, respectively. |
|
V12295 | Basimglurant sulfate (RG 7090; RO 491752) | 802906-73-6 | Basimglurant sulfate (RG7090; RO491752) is a potent, selective and orally bioavailable mGlu5 negative allosteric modulator with a Kd of 1.1 nM. |
|
V70615 | BMS-984923 | 1375752-78-5 | BMS-984923 is a potent mGluR5 silent isomeric modulator with good affinity (Ki = 0.6 nM), good oral bioavailability (F) and BBB (blood-brain barrier) permeability. |
|
V3355 | CFMTI | 864864-17-5 | CFMTI is a novel, potent and selective allosteric antagonist of metabotropic glutamate receptor (mGluR) 1 with IC50 of 2.6 nM. |
|
V70599 | CPCCOEt | 179067-99-3 | CPCCOEt is a low-affinity, selective, noncompetitive and reversible antagonist of metabotropic glutamate receptor 1b (mGluR1b). |
|
V70614 | CVN636 | 2226732-62-1 | CVN636 is an orally bioactive, selective mGluR7 allosteric agonist/activator with EC50 of 7 nM for hu mGluR7. |
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