Dopamine Transporter

Dopamine Transporter

A plasma membrane protein called dopamine transporter (DAT) mediates extracellular dopamine (DA) reuptake and regulates the spatiotemporal dynamics of dopaminergic neurotransmission. DATs are essential for stopping dopaminergic signaling and preserving a dopamine pool that can be released. DATs actively shuttle released transmitter molecules back across the plasma membrane into dopaminergic neurons, where they can be sequestered for later use or enzymatic catabolism. This helps to modulate the concentration of extraneuronal dopamine.
DAT is the primary target of a number of psychostimulants, nootropics, antidepressants, and some recreational drugs, such as the notoriously addictive stimulant cocaine. Cocaine-like inhibitors and amphetamine-like substrates are the two categories into which DAT ligands have traditionally been divided. A number of signaling systems, including PKC, control DAT.

Dopamine Transporter related products

Structure Cat No. Product Name CAS No. Product Description
V71787 (R)-Phenylpiracetam (MRZ 9547) 949925-07-9
V71786 13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol) 178765-49-6
V71788 3-CPMT (Tropine 4-chlorobenzhydryl ether hydrochloride) 14008-79-8
V71785 5,7-Dimethoxyluteolin 90363-40-9
V71784 AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) 202646-03-5
V70652 CAD031 2071209-49-7
V29672 Dasotraline 675126-05-3 Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 of 4, 6, and 11 nM, respectively.
V70004 Desipramine-d3 (desipramine hydrochloride-d3; desipramine hydrochloride-d3) 65100-49-4
V70006 Desipramine-d4 (desipramine hydrochloride-d4; desipramine hydrochloride-d4) 61361-34-0
V2046 GBR 12935 76778-22-8 GBR-12935 is a novel, potent and selective dopamine reuptake inhibitor.
V2045 GBR 12935 HCl 67469-81-2 GBR-12935 is a novel, potent and selective dopamine reuptake inhibitor and a piperazine derivative.
V27943 Vanoxerine dihydrochloride 67469-78-7 Vanoxerine dihydrochloride (GBR-12909; I-893) is a novel, potent, competitive and highly selective dopamine ruptake inhibitor (Ki=1 nM) with the potential for the treatment of atrial fibrillation.
V71783 Z1078601926 1493256-85-1
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