It is well known that ATM/ATR, which belong to the phosphatidyl inositol 3-kinase-like family of serine/threonine protein kinases (PIKKs), are key players in the mitotic DNA damage response (DDR), which mounts responses to single-stranded DNA (ssDNA) and DNA double-strand breaks (DSBs), respectively. Ionizing radiation activates the signal transduction pathways that cause cell cycle arrest at G1/S, S, and G2/M by activating the ATM.In response to DNA-damaging agents like ultraviolet radiation that cause hefty lesions, ATR is necessary for cell cycle arrest.
In order to stabilize stalled replication forks, repair damaged DNA, and stop the cell cycle from continuing, ATM/ATR phosphorylate a wide range of targets upon activation. This helps to ensure cell survival and protect the integrity of the genome. The cell cycle checkpoints activated by ATM and ATR act as an active defense against tumorigenesis and genome instability in replicating cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V55748 | (Rac)-Lartesertib ((Rac)-M4076; (Rac)-ATM Inhibitor-5) | 2020089-41-0 | (Rac)-Lartesertib ((Rac)-M4076; (Rac)-ATM Inhibitor-5) is an isomer of Lartesertib . |
|
V78666 | A011 | A011 is a potent and specific inhibitor of ataxia-telangiectasia mutated (ATM) with IC50 of 1.0 nM. | |
|
V34816 | Antitumor agent-28 | 2097499-67-5 | Antitumor agent-28 selectively regulates ataxia telangiectasia mutated (ATM) kinase. |
|
V88582 | ART0380 | 2267316-76-5 | ART0380 is a potent and selective ATR kinase inhibitor. |
|
V70226 | ATM Inhibitor-2 | 2769140-29-4 | ATM Inhibitor -2 (Compound 7) is a potent and specific ATM inhibitor (antagonist) with IC50 of <1 nM. |
|
V55751 | ATM Inhibitor-6 | 2765544-85-0 | ATM Inhibitor-6 (A-193) is a selective inhibitor of ATM kinase. |
|
V78679 | ATM Inhibitor-8 | 2956666-60-5 | ATM Inhibitor-8 (Compound 10r) is a specific, orally bioavailable ATM inhibitor (antagonist) with IC50 of 1.15 nM. |
|
V78820 | ATM Inhibitor-9 | 2951007-81-9 | ATM Inhibitor-9 (Compd 7a) is a potent ATM inhibitor (antagonist) with IC50 of 5 nM for ATM kinase and may be utilized in cancer research. |
|
V88586 | ATR kinase substrate peptide | ATR kinase substrate peptide (compound 45) is a potent and selective inhibitor of ATR protein kinase (Ki=6 nM). | |
|
V55750 | ATR-IN-10 | 2713577-93-4 | ATR-IN-10 is a potent and selective inhibitor of ATR kinase with IC50 of 2.978 μM. |
|
V78472 | ATR-IN-20 | 3012609-63-8 | ATR-IN-20 is a potent inhibitor of ATR (ATM/ATR) with IC50 of 3 nM. |
|
V55752 | ATR-IN-21 | 2905312-17-4 | ATR-IN-21 (compound 60) is a potent ATR inhibitor (antagonist) with IC50 of <1000 nM. |
|
V55753 | ATR-IN-22 | 2905312-07-2 | ATR-IN-22 (Compound 34) is an orally bioactive ATR inhibitor. |
|
V52379 | ATR-IN-23 | 2923800-62-6 | ATR-IN-23 (Compound 34) is a potent and specific ATR inhibitor (antagonist) with IC50 of 1.5 nM. |
|
V55749 | ATR-IN-24 | 2370889-43-1 | ATR-IN-24 (Compound 1) is an ATR inhibitor. |
|
V52378 | ATR-IN-29 | 2761193-67-1 | ATR-IN-29 is a potent orally bioactive ATR kinase inhibitor (antagonist) with IC50 of 1 nM. |
|
V88588 | ATR-IN-30 | 3010273-13-6 | ATR-IN-30 is a selective ATR ligand that can be used to synthesize ATR PROTACs, such as PROTAC ATR degrader-2. |
|
V52919 | ATR-IN-4 | 2574545-45-0 | ATR-IN-4 is a potent ATR inhibitor. |
|
V3123 | BAY-1895344 HCl | 1876467-74-1 | Elimusertib (BAY1895344) HCl, the hydrochloride salt of BAY 1895344, is a potent, selective and orally bioavailable ATR (ataxia telangiectasia and Rad3-related) inhibitor with potential antineoplastic activity. |
|
V88584 | Elimusertib hydrochloride | Elimusertib (BAY 1895344) hydrochloride is a potent, orally bioavailable, selective ATR inhibitor with an IC50 of 7 nM and antitumor activity. |
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