ATM ATR

ATM ATR

It is well known that ATM/ATR, which belong to the phosphatidyl inositol 3-kinase-like family of serine/threonine protein kinases (PIKKs), are key players in the mitotic DNA damage response (DDR), which mounts responses to single-stranded DNA (ssDNA) and DNA double-strand breaks (DSBs), respectively. Ionizing radiation activates the signal transduction pathways that cause cell cycle arrest at G1/S, S, and G2/M by activating the ATM.In response to DNA-damaging agents like ultraviolet radiation that cause hefty lesions, ATR is necessary for cell cycle arrest.

In order to stabilize stalled replication forks, repair damaged DNA, and stop the cell cycle from continuing, ATM/ATR phosphorylate a wide range of targets upon activation. This helps to ensure cell survival and protect the integrity of the genome. The cell cycle checkpoints activated by ATM and ATR act as an active defense against tumorigenesis and genome instability in replicating cells.

ATM ATR related products

Structure Cat No. Product Name CAS No. Product Description
V55748 (Rac)-Lartesertib ((Rac)-M4076; (Rac)-ATM Inhibitor-5) 2020089-41-0
V78666 A011
V34816 Antitumor agent-28 2097499-67-5
V70226 ATM Inhibitor-2 2769140-29-4
V55751 ATM Inhibitor-6 2765544-85-0
V78679 ATM Inhibitor-8
V78820 ATM Inhibitor-9
V55750 ATR-IN-10 2713577-93-4
V78472 ATR-IN-20
V55752 ATR-IN-21 2905312-17-4
V55753 ATR-IN-22 2905312-07-2
V52379 ATR-IN-23 2923800-62-6
V55749 ATR-IN-24 2370889-43-1
V52378 ATR-IN-29 2761193-67-1
V52919 ATR-IN-4 2574545-45-0
V3123 BAY-1895344 diHCl 1876467-74-1 Elimusertib (BAY1895344) diHCl, the dihydrochloride salt of BAY 1895344, is a potent, selective and orally bioavailable ATR (ataxia telangiectasia and Rad3-related) inhibitor with potential antineoplastic activity.
V2965 Elimusertib (BAY1895344) 1876467-74-1 Elimusertib (formerly known as BAY-1895344) is a highly selective and orally bioavailable inhibitor of ATR(ataxia telangiectasia and Rad3-related) with potential anticancer activity.
V77042 Elimusertib-d3 (BAY 1895344-d3)
V3221 HAMNO (NSC111847) 138736-73-9 HAMNO (formerly known as NSC-111847) is a novel,potent and selective protein interaction inhibitor ofreplication protein A(RPA).
V70225 KU-60019 925701-46-8
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