Transcriptional regulator The basic helix-loop-helix leucinezipper (bHLHZipper) protein family includes c-Myc. The c-MYC protein's target genes are involved in a variety of cellular processes, including the cell cycle, survival, protein synthesis, cell adhesion, and the expression of microRNAs. In addition, c-Myc, one of the four factors required for the induction of pluripotent stem (iPS) cells from somatic cells, is thought to contribute to the maintenance of cancer stem-like cells (CSCs). The majority of c-Myc'sbiologicalactivities necessitate heterodimerization with its activation partner Max.
Additionally, c-Myc is a component of a dynamic network, which interacts selectively with different transcriptional coregulators, histone-modifying enzymes, and members of the network. Tumorigenesis is linked to c-MYC expression that is dysregulated as a result of gene amplification, retroviral insertion, or chromosomal translocation. One extremely promising target for cancer treatment is c-Myc.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2724 | 10074-G5 | 413611-93-5 | 10074-G5 is a potent inhibitor of c-Myc-Max dimerization and interaction with an IC50 of 146 μM and with anticancer activities. |
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V108677 | 4-O-Methyl-ascochlorin | 38561-40-9 | 4-O-methyl-ascoclorin (compound MAC) is a derivative of ascoclorin. |
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V1587 | 10058-F4 | 403811-55-2 | 10058-F4 (10058F4; 10058 F4) is a novel potent and selective c-Myc inhibitor with potential antineoplastic activity. |
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V128393 | AGB-374 | AGB-374 is an orally effective NDUFS7 inhibitor. | |
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V128957 | Anticancer agent 263 | Anticancer agent 263 is a potent anticancer agent. | |
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V129150 | Antiproliferative agent-75 | 3102226-11-6 | Antiproliferative agent-75 is an antiproliferative agent with an IC50 value of 0.06 μM against Myc-driven human B cells. |
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V129674 | AV-9606-129 | 783309-48-8 | AV-9606-129 is a USP28 inhibitor with an IC50 < 1 μM. |
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V130623 | BRD4 Inhibitor-40 | 2994635-04-8 | BRD4 Inhibitor-40 is a BRD inhibitor that inhibits BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. |
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V130632 | BRD4-IN-11 | BRD4-IN-11 is an orally effective selective BRD4 inhibitor (IC50 = 26.35 nM (BD1), IC50 = 72.81 nM (BD2)). | |
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V131978 | c-Myc inhibitor 16 iodide | 3061380-62-6 | c-Myc inhibitor 16 iodide is a selective c-Myc G-quadruplex (c-Myc G4) inhibitor. |
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V104825 | Cotylenin A | 12708-37-1 | Cotylenin A is a phenanthroquinone compound that synergizes with vitamin K2 to induce monocyte differentiation and growth arrest, while inhibiting c-Myc expression and inducing cyclin G2 expression in human leukemia HL-60 cells. |
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V112541 | DL78 | 132993-79-4 | DL78 is a potent antimitotic agent. |
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V136376 | FTO-IN-16 | FTO-IN-16 is a prodrug of FTO-IN-15 and is a potent FTO inhibitor. | |
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V114618 | GQC-05 | 501662-77-7 | GQC-05 (NSC338258) is an elliptic pyridine derivative and a highly efficient and selective stabilizer for c-Myc G-tetrachain (c-Myc G4), with a KD value between 0.1 and 1.43 μM. |
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V137386 | HIT211504993 | HIT211504993 is a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 value of 0.070 μM. | |
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V113262 | Hydroxyrubicin | 73113-90-3 | Hydroxyrubicin is an anti-tumor drug. |
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V120315 | Inosine-5'-diphosphate disodium | 54735-61-4 | Inosine-5'-bisphosphate disodium (IDP disodium) is a bait substrate for NM23-H2. |
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V137968 | Inosine-5'-diphosphate-15N4 dilithium | Inosine-5'-diphosphate-15N4 dilithium is a 15N-labeled dilithium inosine-5'-diphosphate. | |
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V51576 | IRES-C11 | 342416-30-2 | IRES-C11 is a selective translation inhibitor that binds to the c-MYC internal ribosome entry site. |
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V138437 | KI-CDK9d-32 | 3054009-82-1 | KI-CDK9d-32 is a highly selective and highly active CDK9 PROTAC degrader (DC50: 0.89 nM). |
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