White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75015 | (R)-TCB2 | 912342-36-0 | (R)-TCB2 is the R-enantiomer of TCB2. |
|
V75016 | 12-Dehydrogingerdione (12-DHGD) | 99742-05-9 | 12-Dehydrogingerdione is an inhibitor (blocker/antagonist) of NO Synthase. |
|
V74366 | 4-Methoxylonchocarpin | 51589-67-4 | 4-Methoxylonchocarpin is an orally bioactive anti-inflammatory agent. |
|
V75031 | Abrezekimab (UCB4144; VR 942) | 2043952-59-4 | Abrezekimab (VR 942) contains CDP7766, a humanized, high-affinity, neutralizing, anti-human IL-13 antibody fragment that binds IL-13. |
|
V77789 | Ac-YVAD-CHO acetate (L-709049 acetate) | Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, and specific tetrapeptide interleukin-1β converting enzyme (ICE) inhibitor (antagonist) with Kis of 3.0 and 0.76 nM in mice and humans, respectively. | |
|
V75033 | Acetyl hexapeptide-49 | 1969409-70-8 | Acetyl hexapeptide-49 is a biologically active peptide with anti-sensitivity effects that has been reported as an ingredient of cosmetics. |
|
V77816 | ADR58 sodium | ADR58 sodium is a potent and specific human oncostatin M (OSM) antagonist that blocks the binding of OSM to gp130 receptors and specifically antagonizes OSM-mediated signaling. | |
|
V74934 | AF12198 | 185413-30-3 | AF12198 is a specific and specific peptide antagonist against the human type I interleukin-1 receptor (IL1R1) (IC50=8 nM), but not against the human type II receptor (IC50=6.7 µM) or murine type I receptor (IC50>200 µM). |
|
V75023 | Afasevikumab (RG 7624; RO 5553110; NI-1401) | 1589503-30-9 | Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody that neutralizes IL-17A and IL-17F. |
|
V74980 | Anrukinzumab (IMA-638) | 910649-32-0 | Anrukinzumab (IMA-638) is a humanized antibody that can inhibit human IL-13. |
|
V74954 | Anti-Human IL-17A | 1229022-83-6 | Anti-Human IL-17A is a fully human anti-interleukin 17A monoclonal antibody (mAb). |
|
V75009 | Anti-inflammatory agent 42 | 877468-30-9 | Anti-inflammatory agent 42 (Compound 10j) is an anti-inflammatory agent. |
|
V78017 | Anti-inflammatory agent 58 | Anti-inflammatory agent 58 is an anti-inflammatory agent that inhibits IL-1β with IC50 of 1.08 μM. | |
|
V78018 | Anti-inflammatory agent 59 | Anti-inflammatory agent 59 is an anti-inflammatory agent that inhibits IL-1β with IC50 of 2.28 μM. | |
|
V79927 | Anti-inflammatory agent 64 | Anti-inflammatory agent 64 (compound 4b) can inhibit the secretion of IL-6 and TNF-α. | |
|
V78043 | Anti-Mouse IL-10 Antibody | Anti-Mouse IL-10 Antibody is an IgG1 antibody inhibitor against mouse IL-10. | |
|
V78048 | Anti-neuroinflammation agent 1 | Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that modulates the polarization of BV2 microglia from the M1 to M2 phenotype. | |
|
V74941 | Astegolimab (atelizumab; MSTT 1041A; RG 6149) | 2173054-79-8 | Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody (mAb) that blocks IL-33 signaling by targeting the IL-33 receptor ST2. |
|
V74963 | Avizakimab (BOS161721) | 2229685-51-0 | Avizakimab (BOS161721) is a humanized IgG1 monoclonal antibody (mAb) targeting interleukin-21 (IL-21). |
|
V75020 | BAA473 | 27240-87-5 | BAA473 is a bile acid analogue and a potent pyranoid inflammasome activator that induces IL-18 secretion by activating the inflammasome in myeloid and intestinal epithelial cells. |
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