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c-Fms

c-Fms

c-FMS (CSF1R, CSF-1R) is a receptor protein-tyrosine kinase of the platelet-derived growth factor receptor (PDGFR) family. The cell surface receptor for IL-34 and CSF1 is called c-FMS. Important functions of c-FMS include regulating haematopoiesis, cell survival, maturation of microglia and monocytes, and immune response regulation.

Osteoclasts and myelomonocytic-lineage cells, like monocytes and macrophages, express c-FMS specifically, and the activation of c-FMS signaling encourages the proliferation or differentiation of these cells. Additionally, it encourages the production of inflammatory mediators like interleukin 6 (IL6) and tumor necrosis factor-alpha (TNF-).

c-Fms related products

Structure Cat No. Product Name CAS No. Product Description
AZ683 V89056 AZ683 953798-95-3 AZ683 is a potent and selective 3-amino-4-phenylaminoquinoline CSF1R inhibitor.
AZD7507 V4238 AZD7507 1041852-85-0 AZD7507 is a novel, potent, selective and orally bioactive 3-amido-4-anilinoquinoline CSF-1R inhibitor with 32 nM cell activity and with antitumor activity.
BPR1R024 mesylate V69288 BPR1R024 mesylate 2763365-40-6 BPR1R024 mesylate is a selective, orally bioactive, colony-stimulating factor-1 receptor (CSF1R) inhibitor.
c-Fms-IN-13 V69274 c-Fms-IN-13 885704-58-5 c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (antagonist) with IC50 of 17 nM.
c-Fms-IN-14 V69272 c-Fms-IN-14 1898210-99-5 c-Fms-IN-14 (Example 76) is a c-Fms inhibitor (antagonist) with IC50 of 4 nM.
c-Fms-IN-15 V88002 c-Fms-IN-15 c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase with IC50 of 563 nM.
cFMS Receptor Inhibitor II V4438 cFMS Receptor Inhibitor II 959860-85-6 cFMS Receptor Inhibitor II (BUN60856; BUN-60856) is a novel, cell-permeable and potent CSF1R (Colony stimulating factor 1 receptor) kinase inhibitor with an IC50 of 80 nM.
cFMS Receptor Inhibitor IV V69284 cFMS Receptor Inhibitor IV 959626-45-0 cFMS receptor blocker/inhibitor IV (Compound 42) is a potent inhibitor of cFMS with IC50 of 0.017 μM.
CSF1R-IN-1 V31740 CSF1R-IN-1 2095849-04-8 CSF1R-IN-1 is an inhibitor (blocker/antagonist) of CSF1R with IC50 of 0.5 nM.
CSF1R-IN-15 V69287 CSF1R-IN-15 2925744-43-8 CSF1R-IN-15 (compound 23) is an inhibitor (blocker/antagonist) of c-Fms.
CSF1R-IN-17 V79871 CSF1R-IN-17 CSF1R-IN-17 (compound 9) is a potent and specific CSF1R antagonist (inhibitor) with IC50 of 0.2 nM.
CSF1R-IN-18 V85452 CSF1R-IN-18
CSF1R-IN-19 V85255 CSF1R-IN-19 1819989-27-9
CSF1R-IN-20 V88003 CSF1R-IN-20 2935479-57-3 CSF1R-IN-20 (compound 7a) is a CSF-1R inhibitor with IC50 of 467 nM.
CSF1R-IN-21 V88000 CSF1R-IN-21 2935479-62-0 CSF1R-IN-21 (compound 7e) is a CSF-1R inhibitor with an IC50 value of 31 nM.
CSF1R-IN-23 V87998 CSF1R-IN-23 2935480-17-2 CSF1R-IN-23 (Compound 7dri) is a selective inhibitor of colony-stimulating factor 1 receptor (CSF1R) with an IC50 of 36.1 nM.
CSF1R-IN-24 V87997 CSF1R-IN-24 3024322-57-1 CSF1R-IN-24 (Example 134) is an orally active CSF1R inhibitor.
CSF1R-IN-25 V88001 CSF1R-IN-25 2070864-23-0 CSF1R-IN-25 (compound 36) is an orally available inhibitor of CSF1R.
Edicotinib hydrochloride V94235 Edicotinib hydrochloride 1559069-92-9 Aditinib hydrochloride is a potent, selective, blood-brain penetrant, and orally available CSF-1R inhibitor with IC50 of 3.2 nM.
Eflapegrastim V69277 Eflapegrastim 1384099-30-2 Eflapegrastim is a humanized IgG4 monoclonal antibody (mAb) and a granulocyte colony-stimulating factor (G-CSF).
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