c-Fms

c-Fms

c-FMS (CSF1R, CSF-1R) is a receptor protein-tyrosine kinase of the platelet-derived growth factor receptor (PDGFR) family. The cell surface receptor for IL-34 and CSF1 is called c-FMS. Important functions of c-FMS include regulating haematopoiesis, cell survival, maturation of microglia and monocytes, and immune response regulation.

Osteoclasts and myelomonocytic-lineage cells, like monocytes and macrophages, express c-FMS specifically, and the activation of c-FMS signaling encourages the proliferation or differentiation of these cells. Additionally, it encourages the production of inflammatory mediators like interleukin 6 (IL6) and tumor necrosis factor-alpha (TNF-).

c-Fms related products

Structure Cat No. Product Name CAS No. Product Description
V69281 Anumigilimab (CSL-324) 2416593-08-1
V69279 Axatilimab (SNDX-6352) 2155851-88-8
V4238 AZD7507 1041852-85-0 AZD7507 is a novel, potent, selective and orally bioactive 3-amido-4-anilinoquinoline CSF-1R inhibitor with 32 nM cell activity and with antitumor activity.
V69288 BPR1R024 mesylate 2763365-40-6
V69274 c-Fms-IN-13 885704-58-5
V69272 c-Fms-IN-14 1898210-99-5
V69275 Cabiralizumab (FPA 008; Anti-Human CSF1R Recombinant Antibody) 1613144-80-1
V4438 cFMS Receptor Inhibitor II 959860-85-6 cFMS Receptor Inhibitor II (BUN60856; BUN-60856) is a novel, cell-permeable and potent CSF1R (Colony stimulating factor 1 receptor) kinase inhibitor with an IC50 of 80 nM.
V69284 cFMS Receptor Inhibitor IV 959626-45-0
V31740 CSF1R-IN-1 2095849-04-8 CSF1R-IN-1 is a novel and potent CSF1R inhibitor ( IC50 = 0.5 nM).
V69287 CSF1R-IN-15 2925744-43-8
V79871 CSF1R-IN-17
V3765 Edicotinib 1142363-52-7 Edicotinib (formerly known as JNJ-527; JNJ-40346527) is a novel selective and orally bioavailable inhibitor of colony-stimulating factor-1 (CSF-1) receptor kinase with anticancer activity.
V69277 Eflapegrastim 1384099-30-2
V69273 Emactuzumab (RG 7155; RO 5509554) 1448221-67-7
V69289 IACS-9439 2231259-36-0
V23228 KI-20227 623142-96-1 KI-20227 is a potent and orally bioavailable inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively).
V69276 Lacnotuzumab (MCS110; Anti-Human B7-H3) 1831128-32-5
V69278 Namilumab (AMG-203; Anti-Human CSF2 Recombinant Antibody) 1206681-39-1
V69286 Otilimab (GSK 3196165; MOR103) 1638332-55-4
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