Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V90508 | (R)-Pioglitazone | 959687-65-1 | (R)-Pioglitazone ((+)-pioglitazone) is the R-isomer of pioglitazone. |
|
V51357 | (S)-Coriolic acid (13(S)-HODE) | 29623-28-7 | (S)-Coriolic acid (13(S)-HODE) is the endogenous ligand that activates PPARγ and is produced when linoleic acid is metabolized by 15-lipoxygenase (15-LOX). |
|
V84017 | 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine (SDPC; DHA-PC; 18:0/22:6 PC) | 59403-52-0 | |
|
V51337 | 10-Nitrolinoleic acid | 774603-04-2 | 10-Nitrolinoleic acid is a novel agonist for the peroxisome proliferator-activated receptor γ (PPARγ). |
|
V51360 | 13-Oxo-9E,11E-octadecadienoic acid | 29623-29-8 | 13-Oxo-9E,11E-octadecadienoic acida an isomer of 9-oxo-ODA, is a novel and selective PPARα activator derived from tomato juice. |
|
V84085 | 17(S)-HDHA | 92693-03-3 | |
|
V83583 | 20-Carboxyarachidonic acid | 79551-84-1 | |
|
V52518 | 23-epi-26-Deoxyactein (27-Deoxyactein) | 501938-01-8 | 23-epi-26-Deoxyactein is a natural, orally biologically active compound with anti-obesity and anti-tumor effects. |
|
V88749 | 25-Hydroxytachysterol3 | 39932-44-0 | 25-Hydroxytachysterol3 is a metabolite of Vitamin D3. |
|
V88754 | 3-Thiatetradecanoic acid | 116296-31-2 | 3-Thiatetradecanoic acid is a substrate for N-myristoyltransferase (NMT), which is involved in the metabolism of thia-fatty acids. |
|
V84134 | 4,5-DiHDPA lactone | 845673-68-9 | |
|
V84426 | 5-Aminosalicylic acid-13C6 hydrochloride (Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) | 1261398-47-3 | |
|
V84137 | 9-HEPE | 286390-03-2 | |
|
V11620 | AMG-131 | 315224-26-1 | AMG-131, also known as(INT-131) is a novel and potent hypoglycemic agent. |
|
V54368 | Anti-NASH agent 1 | 2409685-41-0 | Anti-NASH agent 1 (compound 3d) is an analogue of Elafibranor, a potent PPAR-α/δ agonist targeting non-alcoholic steatohepatitis (NASH). |
|
V50944 | BAY-0069 | 420826-65-9 | BAY-0069 is a novel PPARγ inverse agonist, and its IC50 values for human and mouse PPARγ are 6.3 nM and 24 nM, respectively. |
|
V51342 | BAY-4931 | 423150-91-8 | BAY-4931 is a potent, covalent, selective PPARγ inverse agonist with IC50 of 0.17 nM. |
|
V85378 | BAY-5094 | 2891706-78-6 | |
|
V85379 | BAY-5516 | 2891706-79-7 | |
|
V85720 | BAY-9683 | 2891706-83-3 |
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