Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51357 | (S)-Coriolic acid (13(S)-HODE) | 29623-28-7 | (S)-Coriolic acid (13(S)-HODE) is the endogenous ligand that activates PPARγ and is produced when linoleic acid is metabolized by 15-lipoxygenase (15-LOX). |
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V51337 | 10-Nitrolinoleic acid | 774603-04-2 | 10-Nitrolinoleic acid is a novel agonist for the peroxisome proliferator-activated receptor γ (PPARγ). |
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V51360 | 13-Oxo-9E,11E-octadecadienoic acid | 29623-29-8 | 13-Oxo-9E,11E-octadecadienoic acida an isomer of 9-oxo-ODA, is a novel and selective PPARα activator derived from tomato juice. |
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V52518 | 23-epi-26-Deoxyactein (27-Deoxyactein) | 501938-01-8 | 23-epi-26-Deoxyactein is a natural, orally biologically active compound with anti-obesity and anti-tumor effects. |
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V10743 | Aleglitazar | 475479-34-6 | Aleglitazar (RG-1439; RO-0728804;RG1439; RO0728804) is a novel and potent agonist of peroxisome proliferator-activated receptor (PPARα and PPARγ) with potential antidiabetic effects. |
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V11620 | AMG-131 | 315224-26-1 | AMG-131, also known as(INT-131) is a novel and potent hypoglycemic agent. |
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V29738 | Angeloylgomisin H | 66056-22-2 | Angeloylgomisin H is a novel and potent lignin extract |
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V54368 | Anti-NASH agent 1 | 2409685-41-0 | Anti-NASH agent 1 (compound 3d) is an analogue of Elafibranor, a potent PPAR-α/δ agonist targeting non-alcoholic steatohepatitis (NASH). |
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V3310 | Arhalofenate | 24136-23-0 | Arhalofenate (formerly known as JNJ-39659100 and/or MBX102) is a novel, selective, partial agonist of PPAR-γ (peroxisome proliferator-activated receptor). |
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V42051 | AZD-9574 | 2756333-39-6 | AZD-9574 is a potent, BBB (blood-brain barrier) permeable/penetrable PARP1 inhibitor that displays >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. |
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V3436 | Balaglitazone | 199113-98-9 | Balaglitazone (also known as NNC-610645; NNC-612344; NN-2344; DRF-2593) is a selective partial agonist of PPARγ (peroxisome proliferator-activated receptor) with an EC50 of 1.351 μM for human PPARγ. |
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V50944 | BAY-0069 | 420826-65-9 | BAY-0069 is a novel PPARγ inverse agonist, and its IC50 values for human and mouse PPARγ are 6.3 nM and 24 nM, respectively. |
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V50945 | BAY-4931 | 423150-91-8 | BAY-4931 is a potent, covalent, selective PPARγ inverse agonist with IC50 of 0.17 nM. |
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V51342 | BAY-4931 | 423150-91-8 | BAY-4931 is a potent, covalent, selective PPARγ inverse agonist with IC50 of 0.17 nM. |
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V51330 | Bezafibrate-d6 | 1219802-74-0 | Bezafibrate-d6 is the deuterium labeled Bezafibrate. |
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V3800 | BMS-711939 | 1000998-62-8 | BMS-711939, an analog of BMS-687453, is a novel potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC50 and IC50 of 4 nM for human PPARα and >1000-fold selectivity vs human PPARγ (EC50 of 4.5 μM) and PPARδ (EC50 > 100 μM) in PPAR-GAL4 transactivation assays. |
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V51348 | Bocidelpar (ASP-0367; MA-0211) | 2095128-20-2 | Bocidelpar is a peroxisome proliferator-activated receptor delta (PPAR-δ) modulator. |
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V51347 | Caulophyllogenin | 52936-64-8 | Caulophyllogenin is a novel and potent triterpene saponin extracted from M. polimorpha. |
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V51340 | CAY-10410 | 596104-94-8 | CAY10410 (11-Oxo-prosta-5Z), a 15d-PGJ2 analog, is a novel agonist of PPARγ. |
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V4093 | Choline Fenofibrate | 856676-23-8 | Choline fenofibrate (formerly also known as ABT-335 or choline salt of fenofibric acid) is a novel, synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as anPPARαagonist. |
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