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PPAR

PPAR

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.

PPAR related products

Structure Cat No. Product Name CAS No. Product Description
(E/Z)-Elafibranor V104178 (E/Z)-Elafibranor 824932-88-9 (E/Z)-Elafibranor ((E/Z)-GFT505) is a PPARα/δ agonist with EC50 of 45 and 175 nM, respectively.
(R)-Pioglitazone V90508 (R)-Pioglitazone 959687-65-1 (R)-Pioglitazone ((+)-pioglitazone) is the R-isomer of pioglitazone.
(S)-Coriolic acid (13(S)-HODE) V51357 (S)-Coriolic acid (13(S)-HODE) 29623-28-7 (S)-Coriolic acid (13(S)-HODE) is the endogenous ligand that activates PPARγ and is produced when linoleic acid is metabolized by 15-lipoxygenase (15-LOX).
(±)-CBCQ V103624 (±)-CBCQ 2415352-36-0 (±)-CBCQ is an oxidative product of cannabidiol with an EC50 value of 14.7 μM for peroxisome proliferator-activated receptor γ (PPAR-γ).
1,1'-(Azodicarbonyl)-dipiperidine V107877 1,1'-(Azodicarbonyl)-dipiperidine 10465-81-3 1,1'-Azodicarbonyldipiperidine (ADDP) can be used for the condensation reaction of alcohols and acidic compounds. It can also be used to synthesize GPR120 agonists with anti-diabetic activity, as well as to synthesize PPARα, PPARγ, and PPARδ triple agonists, which can be used in the study of metabolic diseases.
1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine (SDPC; DHA-PC; 18:0/22:6 PC) V84017 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine (SDPC; DHA-PC; 18:0/22:6 PC) 59403-52-0
10-硝基亚油酸 V51337 10-Nitrolinoleic acid 774603-04-2 10-Nitrolinoleic acid is a novel agonist for the peroxisome proliferator-activated receptor γ (PPARγ).
13-Oxo-9E,11E-octadecadienoic acid V51360 13-Oxo-9E,11E-octadecadienoic acid 29623-29-8 13-Oxo-9E,11E-octadecadienoic acida an isomer of 9-oxo-ODA, is a novel and selective PPARα activator derived from tomato juice.
17(S)-HDHA V84085 17(S)-HDHA 92693-03-3
17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid V101027 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid 1233715-28-0 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid (17-Oxo-DHA) is an oxidative metabolite of DHA mediated by lipoxygenase.
17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid V101279 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid 1233715-33-7 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-oxo-DPA; 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) is an electrophilic oxo derivative (EFOX) of docosahexaenoic acid (DHA).
20-Carboxyarachidonic acid V83583 20-Carboxyarachidonic acid 79551-84-1
23-epi-26-Deoxyactein (27-Deoxyactein) V52518 23-epi-26-Deoxyactein (27-Deoxyactein) 501938-01-8 23-epi-26-Deoxyactein is a natural, orally biologically active compound with anti-obesity and anti-tumor effects.
25-Hydroxytachysterol3 V88749 25-Hydroxytachysterol3 39932-44-0 25-Hydroxytachysterol3 is a metabolite of Vitamin D3.
3-Thiatetradecanoic acid V88754 3-Thiatetradecanoic acid 116296-31-2 3-Thiatetradecanoic acid is a substrate for N-myristoyltransferase (NMT), which is involved in the metabolism of thia-fatty acids.
4,5-DiHDPA lactone V84134 4,5-DiHDPA lactone 845673-68-9
5-Aminosalicylic acid-13C6 hydrochloride (Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) V84426 5-Aminosalicylic acid-13C6 hydrochloride (Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) 1261398-47-3
9(10)-Nitrooleate V104343 9(10)-Nitrooleate 1092676-99-7 9(10)-Nitrooleate (9(10)-nitrooleic acid) is a nitro derivative of oleic acid.
9-HEPE V84137 9-HEPE 286390-03-2
9-Octadecynoic acid V107063 9-Octadecynoic acid 506-24-1 9-Octadecynoic acid is a DNA binding agent with a dissociation constant of 1.8 mM.
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