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    Methyldopa (MK-351)
    Methyldopa (MK-351)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1135
    CAS #: 555-30-6; Purity ≥98%

    Description: Methyldopa (marketed under the brand names Aldomet; Dopamet; Dopegyt; Dopergit; Hydopa; Meldopa; Nu-Medopa; MK-351; MK 351), the methylated form of Dopa, is a potent and competitive DOPA decarboxylase inhibitor with antihypertensive effects. It inhibits DOPA decarboxylase with an ED50 of 21.8 mg/kg. Methyldopa is a medication used for high blood pressure. It is one of the preferred treatments for high blood pressure in pregnancy. For other types of high blood pressure including very high blood pressure resulting in symptoms other medications are typically preferred. It can be given by mouth or injection into a vein. Onset of effects is around 5 hours and they last about a day.

    References: Br J Pharmacol Chemother. 1964 Feb;22:72-86.

    Related CAS#: 41372-08-1 [MK-351 hydrate; Methyldopa hydrate; L-(-)-α-Methyldopa hydrate]; 884-39-9 [MK-351 hydrochloride; Methyldopa hydrochloride; L-(-)-α-Methyldopa hydrochloride];  555-29-3 (alpha-Methyldop); 2508-79-4 (Methyldopate HCl); 38821-49-7 (Carbidopa hydrate); 28860-95-9 (Carbidopa)  

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    Molecular Weight (MW)211.21 
    FormulaC10H13NO4
    CAS No.555-30-6 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 2 mg/mL (9.5 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other infoChemical Name: (S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
    InChi Key: CJCSPKMFHVPWAR-JTQLQIEISA-N
    InChi Code: InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1
    SMILES Code: O=C(O)[[email protected]@](C)(N)CC1=CC=C(O)C(O)=C1
    SynonymsDopamet; Dopegit; Dopegyt; Dopergit; Hydopa; Meldopa; Nu-Medopa; Nu Medopa; NuMedopa; Methyldopa; MK-351; MK 351


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