Casein Kinases (CKs), a family of ubiquitous Ser/Thr kinases, control a variety of cellular processes in eukaryotes, including the phosphorylation of proteins that are targets for degradation by the UPS. Casein kinase-1 (CK-1) and casein kinase-2 (CK-2) are two casein kinases that have been characterized from a variety of sources.
Mammals have at least seven different isoforms of CK1 kinases (α, β, γ1-3, δ, and ɛ), and these enzymes phosphorylate different substrates to participate in a variety of physiological processes including DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis. A highly pleiotropic serine-threonine kinase called casein kinase 2 (CK2) phosphorylated more than 300 proteins, many of which are involved in the regulation of cellular processes like signal transduction, transcriptional control, apoptosis, and the cell cycle.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V5155 | TBB (NSC 231634; Casein Kinase II Inhibitor I) | 17374-26-4 | TBB (NSC 231634; Casein Kinase II Inhibitor I) is a novel, potent, cell-permeable and ATP-competitive inhibitor of protein kinase CK2 with an IC50of 0.15 μM for rat liver CK2. |
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