Casein Kinases (CKs), a family of ubiquitous Ser/Thr kinases, control a variety of cellular processes in eukaryotes, including the phosphorylation of proteins that are targets for degradation by the UPS. Casein kinase-1 (CK-1) and casein kinase-2 (CK-2) are two casein kinases that have been characterized from a variety of sources.
Mammals have at least seven different isoforms of CK1 kinases (α, β, γ1-3, δ, and ɛ), and these enzymes phosphorylate different substrates to participate in a variety of physiological processes including DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis. A highly pleiotropic serine-threonine kinase called casein kinase 2 (CK2) phosphorylated more than 300 proteins, many of which are involved in the regulation of cellular processes like signal transduction, transcriptional control, apoptosis, and the cell cycle.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0957 | CX-4945 (Silmitasertib) | 1009820-21-6 | Silmitasertib (CX-4945; CX4945; CX 4945) is a potent, selective, orally bioavailable small-molecule inhibitor of CK2 (casein kinase 2) with potential anticancer activity. |
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V0958 | D 4476 | 301836-43-1 | D 4476 (D-4476; D4476; Casein Kinase I Inhibitor) is a potent, selective, and cell-permeantinhibitor of CK1 (casein kinase 1) with potential antitumor activity. |
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V29439 | DMAT (CK2 Inhibitor; Casein kinase II Inhibitor) | 749234-11-5 | DMAT (CK2 Inhibitor; Casein kinase II Inhibitor) is a novel, potent and selective CK2 (Casein kinase II) inhibitor with an IC50 value of 130 nM. |
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V0868 | Emodin | 518-82-1 | Emodin (HSDB-7093; NSC-408120; NSC-622947;Emodol;Frangula emodin), a naturally occuring anthraquinoneanalog found in rubarb,buckthorn,andJapaneseknotweed, isa potent and broad-spectrum anticancer agent that also hasanti-inflammatoryand neuroprotective effects. |
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V15145 | Hematein | 475-25-2 | Hematein (Haematein) is a oxidized analogue of Hematoxylin usedas a dye. |
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V2584 | NCC007 | 2342583-66-6 | NCC007 is a dual casein kinase Iα (CKIα) and delta (CKIδ) inhibitor (antagonist) with IC50 of 1.8 and 3.6 μM, respectively. |
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V3427 | PF-670462 | 950912-80-8 | PF-670462 (also known as PF670462; PF670) is a novel, potent and selective inhibitor ofcasein kinase (CK1εandCK1δ) with anticancer activity. |
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V3428 | PF4800567 | 1188296-52-7 | PF-4800567 (PF4800567) is a novel, potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ) with potential utility in treating circadian disorders. |
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V4647 | PUN51207 | 1784751-20-7 | PUN51207 (also known as CK1-IN-1) is a novel and potent casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1. |
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V2616 | Silmitasertib (CX-4945) Sodium | 1309357-15-0 | Silmitasertib(also know as CX-4945) is a selective and orally bioavailable small-molecule inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, it is less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). |
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V3426 | SR-3029 | 1454585-06-8 | SR-3029 is a novel,potent, highly kinase selective and ATP competitiveCK1δandCK1ε (casein kinase 1δ/1ε)inhibitor withIC50s of 44 nM and 260 nM, respectively, andKis of 97 nM for both kinases. |
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V12863 | SU5607 | 186611-52-9 | IC261 is a selective, ATP-competitive CK1 inhibitor (antagonist) with IC50s of 1 μM, 1 μM and 16 μM for Ckiδ, Ckiε and Ckiα1 respectively. |
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V5155 | TBB (NSC 231634; Casein Kinase II Inhibitor I) | 17374-26-4 | TBB (NSC 231634; Casein Kinase II Inhibitor I) is a novel, potent, cell-permeable and ATP-competitive inhibitor of protein kinase CK2 with an IC50of 0.15 μM for rat liver CK2. |
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V3398 | TTP 22 | 329907-28-0 | TTP 22 is a novel, selective and potent inhibitor ofhuman protein kinaseCK2 with anIC50of 100 nM and aKiof 40 nM. |
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