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Casein Kinase

Casein Kinase

Casein Kinases (CKs), a family of ubiquitous Ser/Thr kinases, control a variety of cellular processes in eukaryotes, including the phosphorylation of proteins that are targets for degradation by the UPS. Casein kinase-1 (CK-1) and casein kinase-2 (CK-2) are two casein kinases that have been characterized from a variety of sources. 

Mammals have at least seven different isoforms of CK1 kinases (α, β, γ1-3, δ, and ɛ), and these enzymes phosphorylate different substrates to participate in a variety of physiological processes including DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis. A highly pleiotropic serine-threonine kinase called casein kinase 2 (CK2) phosphorylated more than 300 proteins, many of which are involved in the regulation of cellular processes like signal transduction, transcriptional control, apoptosis, and the cell cycle.

Casein Kinase related products

Structure Cat No. Product Name CAS No. Product Description
CX-4945 (Silmitasertib) V0957 CX-4945 (Silmitasertib) 1009820-21-6 Silmitasertib (CX-4945; CX4945; CX 4945) is a potent, selective, orally bioavailable small-molecule inhibitor of CK2 (casein kinase 2) with potential anticancer activity.
D 4476 V0958 D 4476 301836-43-1 D 4476 (D-4476; D4476; Casein Kinase I Inhibitor) is a potent, selective, and cell-permeantinhibitor of CK1 (casein kinase 1) with potential antitumor activity.
DMAT (CK2 Inhibitor; Casein kinase II Inhibitor) V29439 DMAT (CK2 Inhibitor; Casein kinase II Inhibitor) 749234-11-5 DMAT (CK2 Inhibitor; Casein kinase II Inhibitor) is a novel, potent and selective CK2 (Casein kinase II) inhibitor with an IC50 value of 130 nM.
Emodin V0868 Emodin 518-82-1 Emodin (HSDB-7093; NSC-408120; NSC-622947;Emodol;Frangula emodin), a naturally occuring anthraquinoneanalog found in rubarb,buckthorn,andJapaneseknotweed, isa potent and broad-spectrum anticancer agent that also hasanti-inflammatoryand neuroprotective effects.
Hematein V15145 Hematein 475-25-2 Hematein (Haematein) is a oxidized analogue of Hematoxylin usedas a dye.
NCC007 V2584 NCC007 2342583-66-6 NCC007 is a dual casein kinase Iα (CKIα) and delta (CKIδ) inhibitor (antagonist) with IC50 of 1.8 and 3.6 μM, respectively.
PF-670462 V3427 PF-670462 950912-80-8 PF-670462 (also known as PF670462; PF670) is a novel, potent and selective inhibitor ofcasein kinase (CK1εandCK1δ) with anticancer activity.
PF4800567 V3428 PF4800567 1188296-52-7 PF-4800567 (PF4800567) is a novel, potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ) with potential utility in treating circadian disorders.
PUN51207 V4647 PUN51207 1784751-20-7 PUN51207 (also known as CK1-IN-1) is a novel and potent casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1.
Silmitasertib (CX-4945) Sodium V2616 Silmitasertib (CX-4945) Sodium 1309357-15-0 Silmitasertib(also know as CX-4945) is a selective and orally bioavailable small-molecule inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, it is less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay).
SR-3029 V3426 SR-3029 1454585-06-8 SR-3029 is a novel,potent, highly kinase selective and ATP competitiveCK1δandCK1ε (casein kinase 1δ/1ε)inhibitor withIC50s of 44 nM and 260 nM, respectively, andKis of 97 nM for both kinases.
SU5607 V12863 SU5607 186611-52-9 IC261 is a selective, ATP-competitive CK1 inhibitor (antagonist) with IC50s of 1 μM, 1 μM and 16 μM for Ckiδ, Ckiε and Ckiα1 respectively.
TBB (NSC 231634; Casein Kinase II Inhibitor I) V5155 TBB (NSC 231634; Casein Kinase II Inhibitor I) 17374-26-4 TBB (NSC 231634; Casein Kinase II Inhibitor I) is a novel, potent, cell-permeable and ATP-competitive inhibitor of protein kinase CK2 with an IC50of 0.15 μM for rat liver CK2.
TTP 22 V3398 TTP 22 329907-28-0 TTP 22 is a novel, selective and potent inhibitor ofhuman protein kinaseCK2 with anIC50of 100 nM and aKiof 40 nM.
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