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Src

Src

Src, Yes, Fyn, and Fgr make up the SrcA subfamily, while Lck, Hck, Blk, and Lyn belong to the SrcB subfamily, and Frk has its own subfamily. The Src family kinase (SFK) family of non-receptor tyrosine kinases has nine members in total. Src-family kinases (SFKs) have been identified as important immune cell regulators of numerous intracellular signaling pathways.Src-family kinases (SFKs) participate in a number of signaling transduction cascades, including those originating from integrins, growth factor receptors, T and B cell antigen receptors, and Fc receptors. Src-family kinases (SFKs) can play both positive and negative regulatory roles in cellular signaling.By phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, they can attract and activate inhibitory molecules like the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1) and act as negative regulators of cellular signaling.

Src related products

Structure Cat No. Product Name CAS No. Product Description
Bosutinib (SKI-606; Bosulif) V0665 Bosutinib (SKI-606; Bosulif) 380843-75-4 Bosutinib (formerly also known as SKI-606; trade name Bosulif) is a novel, quinolone-based, andpotent dual Src/Abl kinase inhibitor with potential antitumor activity.
Lck-IN-2 V83632 Lck-IN-2 2615173-24-3
PP1 V0668 PP1 172889-26-8 PP1 (known also as EI275; EI-275; PP-1; PP 1; AG1872; AG-1872) is a novel, potent and selective Src kinase inhibitor with potential antitumor activity.
PP2 (AG1879) V0667 PP2 (AG1879) 172889-27-9 PP2 (also known as AG 1879; AG-1879) a novel, potent,reversible, and ATP-competitiveand selective Src family kinase inhibitor with potential anticancer activity.
Saracatinib (AZD0530) V0664 Saracatinib (AZD0530) 379231-04-6 Saracatinib (formerly also known as AZD-0530; AZD0530) is a novel, potent Src kinase inhibitor with potential antineoplastic activity.
Src I1 V0093 Src I1 179248-59-0 Src Inhibitor 1 (Src-I1) is a novel, potent and selective dual site inhibitor of Srctyrosine kinaseswith potential anticancer activity.
SU6656 V0669 SU6656 330161-87-0 SU 6656 (SU-6656) is a novel, potent and selective Src family kinase (Src, Yes, Lyn, and Fyn) inhibitor with potential antineoplastic activity.
Tirbanibulin (KX2391; KX-O1) V0666 Tirbanibulin (KX2391; KX-O1) 897016-82-9 Tirbanibulin (also known as KXO1; KX2-391; Klisyri) is novel, potent and the first clinical peptidomimetic Src kinase inhibitor as well as a mitotic/tubulin inhibitor with potential anticancer activity.
UM-164 V3287 UM-164 903564-48-7 UM-164, a dasatinib analogue, isa potent and dual inhibitor of the Src/p38 kinase with potential anticancer activity for Triple-Negative Breast Cancer (TNBC).
WH-4-023 V0670 WH-4-023 837422-57-8 WH-4-023 (also called KIN112;WH-4023;KIN-001-112) is a novel, potent,selectiveand orally bioactive inhibitor ofSrc family kinase(dual Lck/Src inhibitor)with potential anti-inflammatory and anticancer activity.
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