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Src

Src

Src, Yes, Fyn, and Fgr make up the SrcA subfamily, while Lck, Hck, Blk, and Lyn belong to the SrcB subfamily, and Frk has its own subfamily. The Src family kinase (SFK) family of non-receptor tyrosine kinases has nine members in total. Src-family kinases (SFKs) have been identified as important immune cell regulators of numerous intracellular signaling pathways.Src-family kinases (SFKs) participate in a number of signaling transduction cascades, including those originating from integrins, growth factor receptors, T and B cell antigen receptors, and Fc receptors. Src-family kinases (SFKs) can play both positive and negative regulatory roles in cellular signaling.By phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, they can attract and activate inhibitory molecules like the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1) and act as negative regulators of cellular signaling.

Src related products

Structure Cat No. Product Name CAS No. Product Description
(R)-LW-Srci-8 V88068 (R)-LW-Srci-8 (R)-LW-Srci-8 is a selective covalent inhibitor of c-Src (IC50= 35.83 nM), which can impair the autophosphorylation of c-Src by targeting the autophosphorylation site (Y419) of c-Src kinase.
AG01 V119770 AG01 AG01 is a monoclonal antibody targeting the granule protein precursor (GP88).
Antifibrotic agent 1 V129018 Antifibrotic agent 1 Antifibrotic agent 1 is an orally effective anti-idiopathic pulmonary fibrosis (IPF) drug.
CGP062464 V131445 CGP062464 121405-24-1 CGP062464 is a c-Src tyrosine kinase inhibitor (IC50: < 50 nM).
Cisplatin/Dasatinib prodrug-1 V88070 Cisplatin/Dasatinib prodrug-1 Cisplatin/Dasatinib prodrug-1 (Compound 3) is a prodrug of Cisplatin and Dasatinib.
CSK substrate V88069 CSK substrate CSK substrate is a specific substrate of C-terminal Src kinase (CSK), which can bind to CSK and downregulate the levels of Src family members.
DFCI-002-06 V108919 DFCI-002-06 3092208-36-8 DFCI-002-06 is an orally effective dual-target HCK/BTK protein degrader with DC₅₀ values of 1.3 nM for HCK and 4.5 nM for BTK.
FAK inhibitor 7 V97116 FAK inhibitor 7 2890814-94-3 FAK inhibitor 7 is a FAK inhibitor with IC50 of 3.58 nM.
FITC-amide-C2 Lck inhibitor 2 V113526 FITC-amide-C2 Lck inhibitor 2 1338346-32-9 FITC-amide-C2 Lck inhibitor 2 is a FITC-labeled Lck inhibitor.
FRK Recombinant Human Active Protein Kinase V119000 FRK Recombinant Human Active Protein Kinase FRK recombinant human active protein kinase is a non-receptor tyrosine kinase belonging to the Fyn-associated kinase family and is a member of the BRK kinase family (BFK).
FYN Y531F Recombinant Human Active Protein Kinase V118909 FYN Y531F Recombinant Human Active Protein Kinase FYN Y531F recombinant human active protein kinase is an oncogene that directly activates YANK2 by phosphorylation of the Y110 site.
Fyn-IN-1 V109918 Fyn-IN-1 3107638-80-9 Fyn-IN-1 (compound 43) is a selective blood-brain barrier penetration inhibitor that inhibits Fyn and GSK-3β, with IC50 values of 0.044 μM and 0.61 μM, respectively.
Hck-IN-2 V137147 Hck-IN-2 Hck-IN-2 is an HCK inhibitor.
Hck-IN-3 V116671 Hck-IN-3 Hck-IN-3 (compound 2D) is an orally effective HCK inhibitor (KD = 3.92 μM).
Herbimycin B V137308 Herbimycin B 76207-83-5 Herbimycin B is an anisoxamycin antibiotic that acts as a Src family kinase inhibitor.
Hibarimicin A V137354 Hibarimicin A 208588-76-5 Hibarimicin A is a tyrosine kinase inhibitor found in the subspecies *Hibaria* of *Microsporum roseum*.
Hibarimicin B V137355 Hibarimicin B 151687-86-4 Hibarimicin B is a tyrosine kinase inhibitor.
Hibarimicin C V137356 Hibarimicin C 208588-83-4 Hibarimicin C is a tyrosine kinase inhibitor.
Hibarimicin D V137357 Hibarimicin D 208588-87-8 Hibarimicin D is a tyrosine kinase inhibitor.
Hibarimicin G V137358 Hibarimicin G 208588-90-3 Hibarimicin G is a tyrosine kinase inhibitor found in the subspecies of Microsporum roseum, Hibarimicin G.
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