Src

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Src

Src, Yes, Fyn, and Fgr make up the SrcA subfamily, while Lck, Hck, Blk, and Lyn belong to the SrcB subfamily, and Frk has its own subfamily. The Src family kinase (SFK) family of non-receptor tyrosine kinases has nine members in total. Src-family kinases (SFKs) have been identified as important immune cell regulators of numerous intracellular signaling pathways.Src-family kinases (SFKs) participate in a number of signaling transduction cascades, including those originating from integrins, growth factor receptors, T and B cell antigen receptors, and Fc receptors. Src-family kinases (SFKs) can play both positive and negative regulatory roles in cellular signaling.By phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, they can attract and activate inhibitory molecules like the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1) and act as negative regulators of cellular signaling.

Src related products

Cat No.	Product Name	CAS No.	Product Description
V88068	(R)-LW-Srci-8		(R)-LW-Srci-8 is a selective covalent inhibitor of c-Src (IC50= 35.83 nM), which can impair the autophosphorylation of c-Src by targeting the autophosphorylation site (Y419) of c-Src kinase.
V0665	Bosutinib (SKI-606; Bosulif)	380843-75-4	Bosutinib (formerly also known as SKI-606; trade name Bosulif) is a novel, quinolone-based, andpotent dual Src/Abl kinase inhibitor with potential antitumor activity.
V88070	Cisplatin/Dasatinib prodrug-1		Cisplatin/Dasatinib prodrug-1 (Compound 3) is a prodrug of Cisplatin and Dasatinib.
V88069	CSK substrate		CSK substrate is a specific substrate of C-terminal Src kinase (CSK), which can bind to CSK and downregulate the levels of Src family members.
V87990	KIN-8194	330786-01-1	KIN-8194 is an orally active dual inhibitor of HCK and BTK with IC50 values of 0.915 and 0.495 nM, respectively.
V83632	Lck-IN-2	2615173-24-3
V88074	pFYN peptide		pFYN peptide is a biotinylated, phosphorylated peptide substrate derived from FYN (Src family kinase).
V0668	PP1	172889-26-8	PP1 (known also as EI275; EI-275; PP-1; PP 1; AG1872; AG-1872) is a novel, potent and selective Src kinase inhibitor with potential antitumor activity.
V0667	PP2 (AG1879)	172889-27-9	PP2 (also known as AG 1879; AG-1879) a novel, potent,reversible, and ATP-competitiveand selective Src family kinase inhibitor with potential anticancer activity.
V0664	Saracatinib (AZD0530)	379231-04-6	Saracatinib (formerly also known as AZD-0530; AZD0530) is a novel, potent Src kinase inhibitor with potential antineoplastic activity.
V0093	Src I1	179248-59-0	Src Inhibitor 1 (Src-I1) is a novel, potent and selective dual site inhibitor of Srctyrosine kinaseswith potential anticancer activity.
V88075	SRC-3-IN-1		SRC-3-in-1 (compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor (IC50=3.3 μM).
V88072	SRC-3-IN-2		SRC-3-IN-2 (SI-12 6c) is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor.
V0669	SU6656	330161-87-0	SU 6656 (SU-6656) is a novel, potent and selective Src family kinase (Src, Yes, Lyn, and Fyn) inhibitor with potential antineoplastic activity.
V0666	Tirbanibulin (KX2391; KX-O1)	897016-82-9	Tirbanibulin (also known as KXO1; KX2-391; Klisyri) is novel, potent and the first clinical peptidomimetic Src kinase inhibitor as well as a mitotic/tubulin inhibitor with potential anticancer activity.
V3287	UM-164	903564-48-7	UM-164, a dasatinib analogue, isa potent and dual inhibitor of the Src/p38 kinase with potential anticancer activity for Triple-Negative Breast Cancer (TNBC).
V0670	WH-4-023	837422-57-8	WH-4-023 (also called KIN112;WH-4023;KIN-001-112) is a novel, potent,selectiveand orally bioactive inhibitor ofSrc family kinase(dual Lck/Src inhibitor)with potential anti-inflammatory and anticancer activity.