Hexokinases (HK) play a central role in cellular glucose metabolism. The first required step of glucose metabolism, the ATP-dependent phosphorylation of glucose (Glc) to produce glucose-6-phosphate (Glc-6-P), is catalyzed by hexokinases. This reaction serves as the initial step in each of the three main pathways of glucose utilization, including glycolysis, the pentose phosphate pathway (PPP), and glycogenesis, in addition to maintaining the gradient of concentrations that allows for facilitated glucose entry into cells.Hexokinases are consequently in a unique position to control the volume and direction of glucose flux within the cell. The PPP serves as the main cellular source of NADPH and is crucial for redox homeostasis, anabolism, and the production of nucleotides like Rib-5-P (ribulose 5-phosphate). Similar to this, glycogenesis and glycolysis both play significant roles in the metabolism and storage of energy. Glc-6-P is also needed as a precursor for other crucial cellular processes, such as the production of hexosamine and nucleotide sugars for the biosynthesis of glycosaminoglycans and glycoproteins (UDP-Glc, uridine diphosphate glucose; UDP-GlcNAc, uridine diphosphate N-acetylglucosamine).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V79770 | Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) | Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable (penetrable) hexokinase II VDAC binding domain. | |
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V2100 | Lonidamine (AF-1890) | 50264-69-2 | Lonidamine (AF 1890, Diclondazolic Acid)is an orally bioactive small molecule inhibitor of hexokinase, also inhibits mitochondrial pyruvate carrier(Ki2.5 μM in isolated rat liver mitochondria) andplasma membrane monocarboxylate transporters. |
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V76593 | PROTAC HK2 Degrader-1 | PROTAC HK2 Degrader-1 is a PROTAC targeting Hexokinase 2 (HK2). |
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