PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V12600 | BGP-15 HCl | 66611-37-8 | BGP-15 HCl is a potent and novel PARP inhibitor that can protect against heart failure and atrial fibrillation in mice. |
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V51302 | 5-AIQ (5-Aminoisoquinolin-1-one) | 93117-08-9 | 5-AIQ (also known as 5-Aminoisoquinolin-1-one) is a water-soluble PARP-1 inhibitor. |
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V52511 | 2-Methylquinazolin-4-ol (2-methyl-4(3H)-quinazolone) | 1769-24-0 | 2-Methylquinazolin-4-ol is a highly efficient and competitive poly(ADP-ribose) synthetase inhibitor with a Ki value of 1.1 μM. |
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V2572 | Picolinamide | 1452-77-3 | Picolinamide (2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine)is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
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V51286 | DR-2313 | 284028-90-6 | DR2313 is a novel and brain-penetrant inhibitor of poly(ADP-ribose) polymerase (PARP), with IC50s of 0.20 μM and 0.24 μM for PARP-1 and PARP-2, respectively. |
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V0306 | PARP-IN-1 (3-aminobenzamide; 3-ABA; 3-AB) | 3544-24-9 | PARP-IN-1(3-Aminobenzamide; 3-ABA; 3-AB) is a novel and potent inhibitor of PARP [Poly(ADP-ribose)polymerase] with potential anticancer activity. |
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V51309 | 3-Methoxybenzamide (3-MBA) | 5813-86-5 | 3-Methoxybenzamide (3-MBA), an inhibitor of PARP and ADP-ribosyltransferase (ADPRTs) prevents Bacillus subtilis cells from dividing, which causes filamentation and ultimately cell lysis. |
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V88723 | 4F-DDC | 4F-DDC is a novel PARP1 inhibitor with an IC50 value of 82 nM. | |
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V56026 | 6(5H)-Phenanthridinone | 1015-89-0 | 6(5H)-Phenanthridinone is a selective and novel PARP-1 inhibitor and immunomodulator. |
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V0313 | A-966492 | 934162-61-5 | A-966492 is a selective andorally bioavailable PARP [poly(ADP-ribose) polymerase] inhibitor with potential anticancer activity. |
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V0305 | AG-14361 | 328543-09-5 | AG14361 (AG-14361) is a novel, potent and selective inhibitor of poly (ADP-ribose) polymerase-1 (PARP1) with potential anticancer activity. |
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V83624 | Amelparib hydrochloride (JPI-289 hydrochloride) | ||
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V51285 | ARTD10/PARP10-IN-1 | 1708103-76-7 | ARTD10/PARP10-IN-1 (compound 23) is a novel inhibitor of PARP that targets the mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10, and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with corresponding IC50 values of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM. |
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V56030 | ARTD10/PARP10-IN-2 | 1708103-69-8 | ARTD10/PARP10-IN-2 (compound 19) is a novel PARP inhibitor. |
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V9075 | AZ6102 | 1645286-75-4 | AZ6102 is a potent and dual inhibitor of tankyrases TNKS1/2 with IC50 valuesof 3 nM and 1 nM, respectively, ithas 100-fold selectivity against other PARP family enzymes and shows 5 nM Wnt pathway inhibition in DLD-1 cells. |
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V88719 | AZD-9574-acid | 2923687-90-3 | AZD-9574-acid (70D) is an inhibitor of PPAR-1 and can be used to synthesize PROTAC (CAS 2923686-70-6). |
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V2571 | AZD0156 | 1821428-35-6 | AZD0156 is a novel, orallybioactive, potent and selective inhibitor of ATM (ataxia telangiectasia mutated) kinase with an IC50 of 0.58 nM and with potential chemo-/radio-sensitizing and antineoplastic activities. |
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V0310 | AZD2461 | 1174043-16-3 | AZD-2461 is a novel, selective and potent inhibitor of Poly (ADP-ribose) polymerase (PARP) with potential anticancer activity. |
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V2569 | BGP-15 | 66611-38-9 | BGP-15 is a potent PARP inhibitor that can protect against heart failure and atrial fibrillation in mice. |
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V56028 | BYK 49187 | 163120-31-8 | BYK 49187 is a novel and potent PARP inhibitor. |