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PARP

PARP

PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).

PARP related products

Structure Cat No. Product Name CAS No. Product Description
2-Methylquinazolin-4-ol (2-甲基-4(3H)-喹唑酮) V52511 2-Methylquinazolin-4-ol (2-methyl-4(3H)-quinazolone) 1769-24-0 2-Methylquinazolin-4-ol is a highly efficient and competitive poly(ADP-ribose) synthetase inhibitor with a Ki value of 1.1 μM.
3-Methoxybenzamide (3-MBA) V51309 3-Methoxybenzamide (3-MBA) 5813-86-5 3-Methoxybenzamide (3-MBA), an inhibitor of PARP and ADP-ribosyltransferase (ADPRTs) prevents Bacillus subtilis cells from dividing, which causes filamentation and ultimately cell lysis.
5-AIQ (5-Aminoisoquinolin-1-one) V51302 5-AIQ (5-Aminoisoquinolin-1-one) 93117-08-9 5-AIQ (also known as 5-Aminoisoquinolin-1-one) is a water-soluble PARP-1 inhibitor.
6(5H)-Phenanthridinone (6(5H)-菲啶酮) V56026 6(5H)-Phenanthridinone 1015-89-0 6(5H)-Phenanthridinone is a selective and novel PARP-1 inhibitor and immunomodulator.
A-966492 V0313 A-966492 934162-61-5 A-966492 is a selective andorally bioavailable PARP [poly(ADP-ribose) polymerase] inhibitor with potential anticancer activity.
AG-14361 V0305 AG-14361 328543-09-5 AG14361 (AG-14361) is a novel, potent and selective inhibitor of poly (ADP-ribose) polymerase-1 (PARP1) with potential anticancer activity.
Amelparib hydrochloride (JPI-289 hydrochloride) V83624 Amelparib hydrochloride (JPI-289 hydrochloride)
ARTD10/PARP10-IN-1 V51285 ARTD10/PARP10-IN-1 1708103-76-7 ARTD10/PARP10-IN-1 (compound 23) is a novel inhibitor of PARP that targets the mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10, and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with corresponding IC50 values of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM.
ARTD10/PARP10-IN-2 V56030 ARTD10/PARP10-IN-2 1708103-69-8 ARTD10/PARP10-IN-2 (compound 19) is a novel PARP inhibitor.
Atamparib (RBN-2397) V38922 Atamparib (RBN-2397) 2381037-82-5 Atamparib (RBN-2397; RBN2397) is a first-in-class, potent,orally bioactive and NAD+ competitiveinhibitor of PARP7 (IC50<3 nM) with antitumor and immunomodulatory effects.
AZ6102 V9075 AZ6102 1645286-75-4 AZ6102 is a potent and dual inhibitor of tankyrases TNKS1/2 with IC50 valuesof 3 nM and 1 nM, respectively, ithas 100-fold selectivity against other PARP family enzymes and shows 5 nM Wnt pathway inhibition in DLD-1 cells.
AZD0156 V2571 AZD0156 1821428-35-6 AZD0156 is a novel, orallybioactive, potent and selective inhibitor of ATM (ataxia telangiectasia mutated) kinase with an IC50 of 0.58 nM and with potential chemo-/radio-sensitizing and antineoplastic activities.
AZD2461 V0310 AZD2461 1174043-16-3 AZD-2461 is a novel, selective and potent inhibitor of Poly (ADP-ribose) polymerase (PARP) with potential anticancer activity.
Benzamide V51308 Benzamide 55-21-0 Benzamide (Benzenecarboxamide) is a novel and seletive inhibitor of poly(ADP-ribose) polymerase (PARP).
BGP-15 V2569 BGP-15 66611-38-9 BGP-15 is a potent PARP inhibitor that can protect against heart failure and atrial fibrillation in mice.
BGP-15 HCl V12600 BGP-15 HCl 66611-37-8 BGP-15 HCl is a potent and novel PARP inhibitor that can protect against heart failure and atrial fibrillation in mice.
BYK 49187 V56028 BYK 49187 163120-31-8 BYK 49187 is a novel and potent PARP inhibitor.
BYK204165 V17321 BYK204165 1104546-89-5

BYK204165 is a novel, potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor with pIC50of 5.38 and 7.35 for PARP-2 and PARP-1 respectively.

CC-115 V2567 CC-115 1228013-15-7 CC-115 (CC115) isa novel and potent dual inhibitor of DNA-PK (DNA-dependent protein kinase) and mTOR (mammalian target of rapamycin) with IC50s of 13 nM and 21 nM, respectively and with potential antineoplastic activity.
CeMMEC1 V2566 CeMMEC1 440662-09-9 CeMMEC1, an N-methylisoquinolinone analog, is a novel and potent inhibitor of TAF4 with anticancer activity.
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