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PARP

PARP

PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).

PARP related products

Structure Cat No. Product Name CAS No. Product Description
(z)-N-(2-羟基-3-(哌啶-1-基)丙氧基)烟酰胺双盐酸盐 V12600 BGP-15 HCl 66611-37-8 BGP-15 HCl is a potent and novel PARP inhibitor that can protect against heart failure and atrial fibrillation in mice.
1-羟基-5-氨基异喹啉 V51302 5-AIQ (5-Aminoisoquinolin-1-one) 93117-08-9 5-AIQ (also known as 5-Aminoisoquinolin-1-one) is a water-soluble PARP-1 inhibitor.
2-Methylquinazolin-4-ol (2-甲基-4(3H)-喹唑酮) V52511 2-Methylquinazolin-4-ol (2-methyl-4(3H)-quinazolone) 1769-24-0 2-Methylquinazolin-4-ol is a highly efficient and competitive poly(ADP-ribose) synthetase inhibitor with a Ki value of 1.1 μM.
2-吡啶甲酰胺 V2572 Picolinamide 1452-77-3 Picolinamide (2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine)is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
3,4-二氢-2H-吡喃[3,2-b]吡啶-4-醇 V51286 DR-2313 284028-90-6 DR2313 is a novel and brain-penetrant inhibitor of poly(ADP-ribose) polymerase (PARP), with IC50s of 0.20 μM and 0.24 μM for PARP-1 and PARP-2, respectively.
3-氨基苯甲酰胺 V0306 PARP-IN-1 (3-aminobenzamide; 3-ABA; 3-AB) 3544-24-9 PARP-IN-1(3-Aminobenzamide; 3-ABA; 3-AB) is a novel and potent inhibitor of PARP [Poly(ADP-ribose)polymerase] with potential anticancer activity.
3-甲氧基苯甲酰胺 V51309 3-Methoxybenzamide (3-MBA) 5813-86-5 3-Methoxybenzamide (3-MBA), an inhibitor of PARP and ADP-ribosyltransferase (ADPRTs) prevents Bacillus subtilis cells from dividing, which causes filamentation and ultimately cell lysis.
4F-DDC V88723 4F-DDC 4F-DDC is a novel PARP1 inhibitor with an IC50 value of 82 nM.
6(5H)-Phenanthridinone (6(5H)-菲啶酮) V56026 6(5H)-Phenanthridinone 1015-89-0 6(5H)-Phenanthridinone is a selective and novel PARP-1 inhibitor and immunomodulator.
A-966492 V0313 A-966492 934162-61-5 A-966492 is a selective andorally bioavailable PARP [poly(ADP-ribose) polymerase] inhibitor with potential anticancer activity.
AG14361 V0305 AG-14361 328543-09-5 AG14361 (AG-14361) is a novel, potent and selective inhibitor of poly (ADP-ribose) polymerase-1 (PARP1) with potential anticancer activity.
Amelparib hydrochloride (JPI-289 hydrochloride) V83624 Amelparib hydrochloride (JPI-289 hydrochloride)
ARTD10/PARP10-IN-1 V51285 ARTD10/PARP10-IN-1 1708103-76-7 ARTD10/PARP10-IN-1 (compound 23) is a novel inhibitor of PARP that targets the mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10, and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with corresponding IC50 values of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM.
ARTD10/PARP10-IN-2 V56030 ARTD10/PARP10-IN-2 1708103-69-8 ARTD10/PARP10-IN-2 (compound 19) is a novel PARP inhibitor.
AZ6102 V9075 AZ6102 1645286-75-4 AZ6102 is a potent and dual inhibitor of tankyrases TNKS1/2 with IC50 valuesof 3 nM and 1 nM, respectively, ithas 100-fold selectivity against other PARP family enzymes and shows 5 nM Wnt pathway inhibition in DLD-1 cells.
AZD-9574-acid V88719 AZD-9574-acid 2923687-90-3 AZD-9574-acid (70D) is an inhibitor of PPAR-1 and can be used to synthesize PROTAC (CAS 2923686-70-6).
AZD0156 V2571 AZD0156 1821428-35-6 AZD0156 is a novel, orallybioactive, potent and selective inhibitor of ATM (ataxia telangiectasia mutated) kinase with an IC50 of 0.58 nM and with potential chemo-/radio-sensitizing and antineoplastic activities.
AZD2461 V0310 AZD2461 1174043-16-3 AZD-2461 is a novel, selective and potent inhibitor of Poly (ADP-ribose) polymerase (PARP) with potential anticancer activity.
BGP-15 V2569 BGP-15 66611-38-9 BGP-15 is a potent PARP inhibitor that can protect against heart failure and atrial fibrillation in mice.
BYK 49187 V56028 BYK 49187 163120-31-8 BYK 49187 is a novel and potent PARP inhibitor.
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