PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52511 | 2-Methylquinazolin-4-ol (2-methyl-4(3H)-quinazolone) | 1769-24-0 | 2-Methylquinazolin-4-ol is a highly efficient and competitive poly(ADP-ribose) synthetase inhibitor with a Ki value of 1.1 μM. |
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V51309 | 3-Methoxybenzamide (3-MBA) | 5813-86-5 | 3-Methoxybenzamide (3-MBA), an inhibitor of PARP and ADP-ribosyltransferase (ADPRTs) prevents Bacillus subtilis cells from dividing, which causes filamentation and ultimately cell lysis. |
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V51302 | 5-AIQ (5-Aminoisoquinolin-1-one) | 93117-08-9 | 5-AIQ (also known as 5-Aminoisoquinolin-1-one) is a water-soluble PARP-1 inhibitor. |
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V56026 | 6(5H)-Phenanthridinone | 1015-89-0 | 6(5H)-Phenanthridinone is a selective and novel PARP-1 inhibitor and immunomodulator. |
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V0313 | A-966492 | 934162-61-5 | A-966492 is a selective andorally bioavailable PARP [poly(ADP-ribose) polymerase] inhibitor with potential anticancer activity. |
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V0305 | AG-14361 | 328543-09-5 | AG14361 (AG-14361) is a novel, potent and selective inhibitor of poly (ADP-ribose) polymerase-1 (PARP1) with potential anticancer activity. |
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V51285 | ARTD10/PARP10-IN-1 | 1708103-76-7 | ARTD10/PARP10-IN-1 (compound 23) is a novel inhibitor of PARP that targets the mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10, and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with corresponding IC50 values of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM. |
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V56030 | ARTD10/PARP10-IN-2 | 1708103-69-8 | ARTD10/PARP10-IN-2 (compound 19) is a novel PARP inhibitor. |
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V38922 | Atamparib (RBN-2397) | 2381037-82-5 | Atamparib (RBN-2397; RBN2397) is a first-in-class, potent,orally bioactive and NAD+ competitiveinhibitor of PARP7 (IC50<3 nM) with antitumor and immunomodulatory effects. |
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V9075 | AZ6102 | 1645286-75-4 | AZ6102 is a potent and dual inhibitor of tankyrases TNKS1/2 with IC50 valuesof 3 nM and 1 nM, respectively, ithas 100-fold selectivity against other PARP family enzymes and shows 5 nM Wnt pathway inhibition in DLD-1 cells. |
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V2571 | AZD0156 | 1821428-35-6 | AZD0156 is a novel, orallybioactive, potent and selective inhibitor of ATM (ataxia telangiectasia mutated) kinase with an IC50 of 0.58 nM and with potential chemo-/radio-sensitizing and antineoplastic activities. |
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V0310 | AZD2461 | 1174043-16-3 | AZD-2461 is a novel, selective and potent inhibitor of Poly (ADP-ribose) polymerase (PARP) with potential anticancer activity. |
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V51308 | Benzamide | 55-21-0 | Benzamide (Benzenecarboxamide) is a novel and seletive inhibitor of poly(ADP-ribose) polymerase (PARP). |
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V2569 | BGP-15 | 66611-38-9 | BGP-15 is a potent PARP inhibitor that can protect against heart failure and atrial fibrillation in mice. |
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V12600 | BGP-15 HCl | 66611-37-8 | BGP-15 HCl is a potent and novel PARP inhibitor that can protect against heart failure and atrial fibrillation in mice. |
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V56028 | BYK 49187 | 163120-31-8 | BYK 49187 is a novel and potent PARP inhibitor. |
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V17321 | BYK204165 | 1104546-89-5 | BYK204165 is a novel, potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor with pIC50of 5.38 and 7.35 for PARP-2 and PARP-1 respectively. |
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V2567 | CC-115 | 1228013-15-7 | CC-115 (CC115) isa novel and potent dual inhibitor of DNA-PK (DNA-dependent protein kinase) and mTOR (mammalian target of rapamycin) with IC50s of 13 nM and 21 nM, respectively and with potential antineoplastic activity. |
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V2566 | CeMMEC1 | 440662-09-9 | CeMMEC1, an N-methylisoquinolinone analog, is a novel and potent inhibitor of TAF4 with anticancer activity. |
N1CCN(CC1)C(%3dO)C2%3dC(C%3dCC(%3dC2)CC3%3dNNC(%3dO)C4%3dC3C%3dC(C%3dC4)C%23C)F)
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V51295 | DB-008 | DB008 is a novel PARP16 inhibitor that contains an electrophilic reagent for acrylamide and has an IC50 value of 0.27 μM. |
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