AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis.It is made up of three proteins (subunits), which when combined form a useful enzyme. The overall result of AMPK activation is stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. This is offset by inhibition of cholesterol, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis, and stimulation of hepatic fatty acid oxidation and ketogenesis. As a metabolic master switch, AMPK controls a number of intracellular processes, such as the uptake of glucose by cells, the -oxidation of fatty acids, and the GLUT4 and mitochondrial biogenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V9698 | 6-Gingerol | 23513-14-6 | [6]-Gingerol is an active substance extracted from ginger that has a variety of bioactivities like anti-cancer, anti~inflammatory, and antioxidant. |
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V0244 | A-769662 | 844499-71-4 | A-769662 (A769662;A 769662), a thienopyridone analog, is a potent, alloesteric and reversible activator of AMPK (AMP-activated protein kinase)with antidiabetic activity. |
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V0245 | Acadesine (AICAR; NSC-105823) | 2627-69-2 | Acadesine (also known as NSC105823,AICA-riboside, and AICAR) is a novel and potent AMPK (AMP-activated protein kinase) activatorwith potential antitumor and antidiabetic activity. |
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V51085 | Aldometanib (LXY-05-029) | aldolase inhibitor | |
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V52430 | Aldometanib (LXY-05-029) | 2904601-67-6 | Aldometanib (LXY-05-029) is an aldolase inhibitor. |
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V77269 | AMARA peptide TFA | AMARA peptide (TFA) is a substrate of salt-induced kinase (SIK) and adenylate-activated protein kinase (AMPK). | |
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V55721 | AMPK activator 10 | 1914176-03-6 | AMPK activator 10 is an orally bioactive AMPK activator with an EC150 of 44.3 nM as measured by cell ELISA. |
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V52421 | AMPK activator 11 | 2948304-00-3 | AMPK activator 11 is an AMP-activated protein kinase activator with nano-level anti-tumor activity and can resist a variety of CRC. |
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V55742 | AMPK activator 12 | 431920-24-0 | AMPK activator 12 (compound 21) is a potent AMPK activator and GDF15 inducer. |
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V77939 | AMPK activator 13 | AMPK activator 13 is a potent AMPK activator. | |
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V77267 | AMPK activator 2 hydrochloride | AMPK activator 2 (compound 7a) HCl is a fluoroguanil analogue that upregulates the AMPK signaling pathway and downregulates mTOR/4EBP1/p70S6K. | |
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V52420 | AMPKactivator 4 | 2493239-46-4 | AMPK activator 4 is a potent AMPK activator and does not inhibit mitochondrial complex I. |
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V55743 | AMPKactivator 9 | 1858204-23-5 | AMPK activator 9 (ZM-6) is a potent activator of AMPK (α2β1γ1) with EC50 of 1.1 µM. |
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V52419 | AMPK-IN-1 | 1219739-95-3 | AMPK-IN-1 is an AMPK activator (EC50 551 nM for isoform α2β2γ1). |
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V70222 | AMPK-α1β1γ1 activator 1 | 1943510-86-8 | AMPK-α1β1γ1 activator 1 (M1) is the acylglucuronide metabolite of the Indole-3-cancer-based AMPK activator. |
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V2166 | ASP4132 tosylate | 1640294-30-9 | ASP4132 tosylate (ASP-4132) is an oral bioavailable AMPK activator (EC50 = 18 nM) with potential anticancer activity. |
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V2440 | BC1618 | 2222094-18-8 | BC1618, an orally bioactive Fbxo48 inhibitor, stimulates Ampk signaling (preventing activated pAmpkα from being degraded by the Fbxo48-mediated proteasome). |
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V6440 | Bempedoic acid (ESP55016; ETC1002) | 738606-46-7 | Bempedoic acid (formerly ESP-55016; ETC-1002; ESP55016; ETC1002;Nexletol;Bempedoate) is an ATP-citrate lyase (ACL) inhibitor as well as an activator of hepatic AMP-activated protein kinase (AMPK). |
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V52531 | Bempedoic acid-d4 (ETC-1002-d4; ESP-55016-d4) | 2408131-70-2 | Bempedoic acid-d4 is the deuterated marker of Bempedoic acid. |
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V56183 | Bempedoic acid-d5 (ETC-1002-d5; ESP-55016-d5) | 2408131-71-3 | Bempedoic acid-d5 is the deuterated form of Bempedoic acid. |
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