The IAP family of inhibitors of apoptosis (IAP) includes survivin. As a result of the survivin protein's ability to prevent caspase activation, apoptosis, or programmed cell death, is negatively regulated. This has been demonstrated by disruption of the pathways that induce survivin, which increases apoptosis and slows tumor growth. Only the G2-M phase of the cell cycle results in the expression of the survival protein. By interacting with tubulin during mitosis, survival localizes to the mitotic spindle and may help control the process. Antisurvivin therapy is a promising cancer treatment option because survivin is highly expressed in the majority of cancers and linked to chemotherapy resistance, increased tumor recurrence, and decreased patient survival.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V121448 | (2''S)-2'',3''-Dihydrodelicaflavone | 3035699-17-0 | (2''S)-2'',3''-Dihydrodelicaflavone is a biflavonoid compound found in the whole herb of Selaginella tamariscina, which exhibits anti-proliferation and apoptosis-inducing activities against non-small cell lung cancer cells. |
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V112667 | ELTLGEFLKL | 303068-29-3 | ELTLGEFLKL is a survivin peptide. |
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V116797 | Gataparsen | 1065019-70-6 | Gataparsen is an antisense oligonucleotide that targets Survivin and has potential antitumor activity. |
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V116856 | Gataparsen sodium | Sodium Gataparsen is an antisense oligonucleotide that targets Survivin and has potential antitumor activity. | |
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V4436 | GDP366 | 501698-03-9 | GDP366 is a novel, potent, selective small molecule and dual inhibitor of survivin and Op18, it induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. |
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V118322 | Isonanangenine B | 1623153-14-9 | Ionanin B (SF002-96-1) is a selective survivin inhibitor (IC50 = 1.6 µM). |
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V138303 | JS04 | JS04 is an EGFR L858R/T790M kinase inhibitor. | |
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V2178 | LQZ 7I | 195822-23-2 | LQZ-7I is a novel malarial protease PfSUB1 inhibitor. |
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V0771 | YM155 (Sepantronium Bromide) | 781661-94-7 | YM155 (also called Sepantronium Bromide; YM-155; YM 155) is a novel and potent survivin inhibitor with potential anticancer activity. |
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V145460 | Survivin-IN-1 | Survivin-IN-1 is a potent inhibitor of Survivin (a member of the apoptosis inhibitor protein family), with an IC50 value of 8.1 μM against human lung cancer A549 cells and an IC50 value of 9.0 μM against breast cancer MCF-7 cells. | |
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V145461 | Survivin-IN-2 | Survivin-IN-2 is a Survivin inhibitor. | |
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V147125 | WMJ-J-09 | 2416914-29-7 | WMJ-J-09 is an HDAC inhibitor with IC50 values of: HDAC1 7.5 nM, HDAC2 21.3 nM, HDAC3 18.4 nM, HDAC8 90.9 nM, HDAC6 3.9 nM, and HDAC4 8715.7 nM. |
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