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PLK

PLK

Polo-like Kinases (PLKs) are a family of highly conserved serine/threonine protein kinases that are essential for a variety of biological functions, including cell division and mitosis checkpoint regulation. Five PLKs (PLK 1-5) play a variety of roles in DNA damage response, intra-S-phase and G2/M checkpoints, spindle formation, and centrosome dynamics in mammals.

PLKs are distinguished by their Polo-box domain, which mediates protein interactions. Depending on the biological context, they are also regulated by transcription, proteolysis, and phosphorylation. PLKs are now understood to function in differentiated cells and link cell division to developmental processes.

PLK related products

Structure Cat No. Product Name CAS No. Product Description
V115339 PLK4-IN-5 PLK4-IN-5 (compound 5f) is a PLK4 inhibitor (IC50 = 0.8 nM).
V109198 BDE30671203 BDE30671203 is a highly selective PLK1 inhibitor (IC50 = 2.163 nM).
V115581 PLK4-IN-6 PLK4-IN-6 (compound C05) is a PLK4 inhibitor (IC50 < 0.1 nM).
V112503 PMV6-PEG4-BI2536 PMV6-PEG4-BI2536 is a p53-Y220C-PLK1 bifunctional compound consisting of a high-affinity p53-Y220C mutant binder (Kd ≈ 2.5 nM) and a potent PLK1 kinase inhibitor (IC50 = 0.83 nM).
V116561 PLK2 Recombinant Human Active Protein Kinase PLK2 belongs to the Polo-like kinase (PLK) family, which includes five mammalian members and plays a central role in the cell cycle and related events.
V109328 POI ligand-4 1403265-80-4 POI ligand-4 is a PLK1 ligand that can be used to synthesize PROTACs, such as PROTAC PLK1 degrader-3.
V109335 POI ligand-3 POI ligand-3 (compound 4j) is a peptide PLK1 PBD inhibitor.
(E/Z)-Rigosertib sodium V1575 (E/Z)-Rigosertib sodium 1225497-78-8 (E/Z)-Rigosertib sodium (formerly known as ON-01910; ON01910; Estybon), the sodium salt ofRigosertib, is a novel, potent and non-ATP-competitive inhibitor of PLK1 with potential anticancer activity.
3MB-PP1 V60036 3MB-PP1 956025-83-5 3MB-PP1 is a bulky purine analog that is a Polo-like kinase 1 (Plk1) inhibitor.
8012–3246 V109883 8012–3246 421586-94-9 8012-3246 is a selective PLK2 inhibitor with an IC50 value of 774.5 nM.
BI 2536 V1573 BI 2536 755038-02-9 BI2536 (BI-2536; BI 2536) is a novel PLK1/BRD4 dual inhibitor with potential antitumor activity.
BI2536-PEG2-Halo V99755 BI2536-PEG2-Halo BI2536-PEG2-Halo is a bifunctional molecule consisting of a Halo-tagged ligand and the Polo-like kinase 1 (PLK1) inhibitor BI-2536.
BTO-1 V52314 BTO-1 40647-02-7 BTO-1 is a Polo-like kinase (Plk) inhibitor.
CD 10899 V88745 CD 10899 1331770-20-7 CD 10899 is a hydroxylated metabolite of Volasertib.
Centrinone V17894 Centrinone 1798871-30-3 Centrinone (LCR263; LCR-263; LCR 263) is a novel and potent inhibitor of polo-like kinase 4 (PLK4)with potential antineoplastic activity.
Centrinone-B V17895 Centrinone-B 1798871-31-4 Centrinone-B (LCR323; LCR-323; LCR 323) is a novel and reversible polo-like kinase 4 (PLK4) inhibitor with potential anticancer activity.
CFI-400437 HCl V2427 CFI-400437 HCl 1247000-76-5 (1E)-CFI-400437 diHCl is potent against PLK4 (IC50= 0.6 nM) and selective for other members of the PLK family (>10 μM).
CFI400945游离碱 V2729 Ocifisertib (CFI-400945) 1338806-73-7 CFI400945 is a potent, selective, and orally bioavailable PLK4 (polo-like kinase 4) inhibitor with IC50 value of 2.8 ±1.4 nM and potential antineoplastic activity.
CZS-241 V51036 CZS-241 3016297-55-2 CZS-241 is a novel Polo-like Kinase (PLK) 4 inhibitor (IC50=2.6 nM).
CZS-241 hydrochloride V110926 CZS-241 hydrochloride CZS-241 hydrochloride is an orally effective selective Polo-like kinase 4 (PLK4) inhibitor (IC50 = 2.6 nM).
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