ERK

ERK

ERKs (Extracellular-signal-regulated kinases) are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.The ERK pathway is activated by a wide range of stimuli, including as growth factors, cytokines, viral infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens. Ras stimulates c-Raf in the MAPK/ERK pathway, which is subsequently joined by mitogen-activated protein kinase kinase (also known as MKK, MEK, or MAP2K), followed by MAPK1/2 (see below).

Ras can be triggered by additional cues in addition to growth hormones through GRB2/SOS and receptor tyrosine kinases. Many transcription factors, including ELK1, and some downstream protein kinases are known to be activated by ERKs. Ras, c-Raf, and receptors like HER2 are known to cause disruption of the ERK pathway, which is frequently seen in malignancies.

ERK related products

Structure Cat No. Product Name CAS No. Product Description
V69825 (R)-VX-11e 1680187-43-2
V69801 (S)-BAY 2965501 2732902-09-7
V69817 7α,15-Dihydroxydehydroabietic acid 155205-64-4
V9020 Adjudin 252025-52-8 Adjudin, formerly known as AF-2364, is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production.
V69823 ADTL-EI1712 2414916-45-1
V33675 AG126 118409-62-4 AG126 is a tyrosine kinase inhibitor which can prevent the activation of mitogen-activated protein kinase p42MAPK (ERK2).
V10837 Alobresib 1637771-14-2 Alobresib (GS-5829) is a novel and potent BET bromodomain inhibitor with anticancer activity.
V51049 ASN-007 benzenesulfonate 2055597-39-0 ERK1/2 inhibitor
V41199 ASN007 2055597-12-9 ASN007 (ASN-007) is a novel, potent, orally bioavailable and selective inhibitor of ERK1/2 with robust antitumor activity.
V7184 Astragaloside IV 84687-43-4 Astragaloside IV (AS-IV), the major active component found in Astragalus membranaceus, has broad application prospects, especially in cardiovascular diseases, digestive diseases, cancer and other modern high incidence, high-risk diseases, and could be developed as a medicine.
V3493 ASTX029 2095719-92-7 ASTX-029(also known as ERK1/2 inhibitor 2) is a highly potent and selective dual-mechanism ERK inhibitor.
V11971 AX15836 2035509-96-5 AX15836 is a novel, highly potent and selective ERK5 inhibitor (IC50= 8 nM).
V3801 AZD-0364 2097416-76-5 AZD0364 is a potent and selective oral inhibitor of ERK1/2 that is efficacious in both monotherapy and combination therapy in models of NSCLC.
V4176 BAY885 2307249-33-6 BAY-885 is a novel, highly potent and selective ERK5/MAPK7 inhibitor with IC50 of 40 nM.
V4221 CC-90003 1621999-82-3 CC-90003 is a novel, potent, selective, orally bioavailable, and irreversible (covalent) inhibitor of ERK1/2 (extracellular signal-regulated kinase) with IC50s in the 10-20 nM range, and displays good kinase selectivity in a 258-kinase biochemical assay.
V0469 DEL-22379 181223-80-3 DEL-22379 is a novel, potent,selective, and water-soluble ERK (extracellular signal-related kinase 2) dimerization inhibitor with potential antitumor activity.
V69804 Edaxeterkib 1695534-88-3
V79303 Endothelin-1 (1-31) (Human) acetate
V77039 Endothelin-1 (1-31) (Human) TFA
V69835 ERK-IN-2 2743576-56-7
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