TGF–beta(Smad)

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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TGF–beta(Smad)

The pleiotropic protein known as transforming growth factor-beta (TGF-) is a member of a superfamily that controls several cellular processes, including growth, development, and differentiation. The Smad proteins, which are the intracellular TGF-beta signaling effectors, are activated by receptors and move into the nucleus where they control transcription. Although this pathway is fundamentally straightforward, cooperation with sequence-specific transcription factors, combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smad-interacting proteins, and other factors enable significant versatility and diversity of TGF-beta family responses. Smad activation and function are further regulated by other signaling pathways.
Additionally, TGF-beta receptors activate Smad-independent pathways that enable Smad-independent TGF-beta responses in addition to regulating Smad signaling. Abnormal TGF- signaling has been linked to a number of illnesses, including cancer, cardiovascular disease, and fibrosis. Consequently, it is acknowledged that the TGF-signaling pathway is a potential drug target.

TGF–beta(Smad) related products

Cat No.	Product Name	CAS No.	Product Description
V78757	Chlorfortunone A		Chlorfortunone A is a new sesquiterpene dimer extracted from the roots of Chloranthus fortunei.
V77079	Disitertide diammonium (P144 diammonium)		Disitertide (P144) diammonium is a bioactive peptide inhibitor of transforming growth factor TGFβ1, which specifically blocks its interaction with the receptor.
V79160	Disitertide TFA (P144 TFA)		Disitertide (P144) TFA is a bioactive peptide inhibitor of transforming growth factor TGFβ1, which specifically blocks its interaction with the receptor.
V106431	Emugrobart		Emugrobart is an IgG1κ humanized antibody against GDF8.
V107424	RepSox hydrochloride	2319939-07-4	RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5).
V22296	Hydrochlorothiazide	58-93-5	Hydrochlorothiazide is a thiazide diureticmedication approved for use in the treatment of high blood pressure and swelling due to fluid build up.