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TGF–beta(Smad)

TGF–beta(Smad)

The pleiotropic protein known as transforming growth factor-beta (TGF-) is a member of a superfamily that controls several cellular processes, including growth, development, and differentiation. The Smad proteins, which are the intracellular TGF-beta signaling effectors, are activated by receptors and move into the nucleus where they control transcription. Although this pathway is fundamentally straightforward, cooperation with sequence-specific transcription factors, combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smad-interacting proteins, and other factors enable significant versatility and diversity of TGF-beta family responses. Smad activation and function are further regulated by other signaling pathways.
Additionally, TGF-beta receptors activate Smad-independent pathways that enable Smad-independent TGF-beta responses in addition to regulating Smad signaling. Abnormal TGF- signaling has been linked to a number of illnesses, including cancer, cardiovascular disease, and fibrosis. Consequently, it is acknowledged that the TGF-signaling pathway is a potential drug target.

TGF–beta(Smad) related products

Structure Cat No. Product Name CAS No. Product Description
Chlorfortunone A V78757 Chlorfortunone A Chlorfortunone A is a new sesquiterpene dimer extracted from the roots of Chloranthus fortunei.
Disitertide diammonium (P144 diammonium) V77079 Disitertide diammonium (P144 diammonium) Disitertide (P144) diammonium is a bioactive peptide inhibitor of transforming growth factor TGFβ1, which specifically blocks its interaction with the receptor.
Disitertide TFA (P144 TFA) V79160 Disitertide TFA (P144 TFA) Disitertide (P144) TFA is a bioactive peptide inhibitor of transforming growth factor TGFβ1, which specifically blocks its interaction with the receptor.
Hydrochlorothiazide V22296 Hydrochlorothiazide 58-93-5 Hydrochlorothiazide is a thiazide diureticmedication approved for use in the treatment of high blood pressure and swelling due to fluid build up.
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