Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) serves as an inducible coregulator in the control of energy homeostasis.PGC-1α is a potent transcriptional coregulator of the mitochondrial and GLUT4 genes, as well as genes encoding parts of the electron transport chain. PGC-1α is highly expressed in tissues that require a lot of energy, such as brown adipose tissue, the heart, skeletal muscle, kidney, and brain. PGC-1α has been found to control heart development, fiber-type switching in skeletal muscle, adaptive thermogenesis, mitochondrial biogenesis, glucose and fatty acid metabolism, and the peripheral circadian clock. PGC-1α, a vital enhancer of mitochondrial function, is a great candidate for preventing metabolic syndromes and insulin resistance that are brought on by mitochondrial dysfunction. It has been demonstrated that PGC-1α affects energy metabolism.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73525 | 11-Oxoisomogroside V | 2149606-15-3 | 11-Oxoisomogroside V (compound 3) is a cucurbitacin extracted from the crude extract of Luo Han Guo. |
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V73523 | Acetyl hexapeptide-38 | 1400634-44-7 | Acetyl hexapeptide-38 is a biologically active peptide with the effect of upregulating lipogenesis and has been reported for use as a cosmetic ingredient. |
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V128643 | AM31 | AM31 is a PGC-1α1 stabilizer. | |
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V128650 | AM73 | 931619-99-7 | AM73 is a PGC-1α1 stabilizer. |
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V128651 | AM89 | AM89 is a PGC-1α1 stabilizer. | |
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V138932 | LJ-2698 | 945457-84-1 | LJ-2698 is an orally effective adenosine A3 receptor antagonist. |
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V73524 | Mogroside VI B (Mogroside VI B) | 2149606-17-5 | Mogroside VI B, a glucoside, was extracted from crude extract of Luo Han Guo. |
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V142099 | PA-082 | 95520-87-9 | PA-082 is a selective PPAR-γ modulator that functions as a partial agonist. |
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V15231 | SR-18292 | 2095432-55-4 | SR-18292 (SR18292) is a novel and potent inhibitor of PGC-1α (PPAR gamma coactivator-1α), which is able to reduce blood glucose, strongly increase hepatic insulin sensitivity, and improve glucose homeostasis in dietary and genetic mouse models of T2D. |
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V1962 | ZLN005 | 49671-76-3 | ZLN005 is a novel, potent and tissue-specific PGC-1α (peroxisome proliferator-activated receptor-γ coactivator-1α) transcriptional activator. |
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V147369 | ZLN005 hydrochloride | 2319647-97-5 | ZLN005 hydrochloride is a peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) activator. |
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