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RIP kinase

RIP kinase

Receptor-interacting protein (RIP) kinases are a class of threonine/serine protein kinases with distinct non-kinase regions and a comparatively conserved kinase domain. The RIPK family consists of seven members, RIPK1 to RIPK7, some of which have become important effectors of immunity against infection with a variety of bacterial, viral, and protozoal pathogens.

Both communicable and non-communicable disease processes depend on the cellular signaling molecules known as RIP kinases for homeostatic signaling. The early control of a wide range of pathogenic organisms requires the action of RIPK1, RIPK2, RIPK3, and RIPK7, which have emerged as important mediators of intracellular signal transduction including inflammation, autophagy, and programmed cell death.

RIP kinase related products

Structure Cat No. Product Name CAS No. Product Description
(Rac)-GSK547 V77366 (Rac)-GSK547 (Rac)-GSK547 is the racemate of GSK547.
Desmethyl-WEHI-345 analog V51418 Desmethyl-WEHI-345 analog 1354825-03-8 protein kinase inhibitor
GSK' 872 (GSK2399872A) V2773 GSK' 872 (GSK2399872A) 1346546-69-7 GSK872 (also known asGSK2399872A, GSK872, orGSK-872) is a novel, potent and selective RIPK3 (receptor interacting protein kinase-3) inhibitor.
GSK-843 V32533 GSK-843 1601496-05-2 GSK-843 (GSK843) is a novel and potent inhibitot of receptor-interacting protein kinase 3 (RIP3 or RIPK3) with anti-inflammatory effects.
GSK-872 hydrochloride V41990 GSK-872 hydrochloride 2703752-81-0 GSK-872 hydrochloride (GSK872; GSK2399872A; GSK872; GSK-872) is a novel, potent and selective RIPK3 (receptor interacting protein kinase-3) inhibitor with anticancer and anti-inflammatory effects.
GSK-963 V3290 GSK-963 2049868-46-2 GSK-963 (also known as GSK963 or GSK963), is a potent and selectiveRIP1 kinase inhibitor.
GSK2593074A V3532 GSK2593074A 1337531-06-2 GSK2593074A (also known as GSK’074) is a novel and potent necroptosisinhibitor with dual targeting ability to bothRIP1andRIP3.
GSK2982772 V2776 GSK2982772 1622848-92-3 GSK2982772 (GSK-2982772; GSK772) is a potent, selective, oral and ATP competitive inhibitor of RIP1 (receptor Interacting Protein 1) with the potentialfor the treatment of inflammatory diseases.
GSK2983559 V34660 GSK2983559 free acid 1579965-12-0 GSK2983559 free acid (compound 3) is a potent, specific and oral bioactive receptor interacting protein 2 (RIP2) kinase inhibitor, showingexcellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.
GSK2983559 V76955 GSK2983559 GSK2983559 (compound 3) is an orally bioactive and potent receptor-interacting protein 2 (RIP2) kinase inhibitor.
GSK2983559 active metabolite V6404 GSK2983559 active metabolite 1423186-80-4 GSK2983559active metabolite, formerly known as RIPK2-IN-1,is an active metabolite of GSK2983559which is a potent and selective inhibitor of receptor interacting protein-2 (RIP2) kinase.
GSK3145095 V32475 GSK3145095 1622849-43-7 GSK3145095 is a RIP1 kinase inhibitor (antagonist) with IC50 of 6.3 nM.
GSK481 V3534 GSK481 1622849-58-4 GSK481 is a novel, potent and selective inhibitor of RIP1 (receptor interacting protein 1) WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.
GSK547 V2059 GSK547 2226735-55-1 GSK547 (GSK547;GSK-547) is a novel, potent and highly selective inhibitor ofRIP1 (receptor-interacting serine/threonine protein kinase 1) with immunomodulatory effects.
GSK583 V2611 GSK583 1346547-00-9 GSK583 is a highly potent and selective RIP2 kinaseinhibitor with an IC50 value of 5 nM.
HS1371 V3954 HS1371 2158197-70-5 HS-1371is a novel, potent and ATP-competitiveRIP3 (receptor-interacting protein kinase 3) inhibitor that is identified by the extensive screening of chemical libraries focused on kinases.
HTH-01-091 TFA V76915 HTH-01-091 TFA HTH-01-091 TFA is a potent and specific inhibitor of maternal embryonic leucine zipper kinase (MELK) with IC50 of 10.5 nM.
MLKL-IN-4 V80791 MLKL-IN-4 3031406-17-1 MLKL-IN-4 (compound 56) is a potent inhibitor of MLKL (mixed lineage kinase domain-like protein).
NDs-IN-1 V88542 NDs-IN-1 3033806-97-9 (Neurodegenerative Diseases) NDs-IN-1 (Compound 3g) inhibits the activities of key enzymes such as hBACE-1, hAChE and hMAO-B.
Necroptosis-IN-4 V88524 Necroptosis-IN-4 Necroptosis-IN-4 is a potent necroptosis inhibitor and a RIP kinase 1 (RIPK1) inhibitor.
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