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FAP

FAP

The cell-surface serine protease known as fibroblast activation protein (FAP) affects different hormones and elements of the extracellular matrix. FAP is frequently used as a marker for pro-tumorigenic stroma and is highly upregulated in a variety of cancers.

FAP related products

Structure Cat No. Product Name CAS No. Product Description
3BP-3940 V86175 3BP-3940 2803421-14-7
[99mTc]Tc-6–1 V86846 [99mTc]Tc-6–1 [99m Tc]Tc-6-1 is a 99mTc-labeled FAPI-46 derivative and a specific fibroblast activation protein (FAP) targeted radiotracer.
AlF-PD-FAPI V85878 AlF-PD-FAPI
DOTA-2P (FAPI)2 V118440 DOTA-2P (FAPI)2 DOTA-2P(FAPI)2 is a dimeric FAP (fibroblast activating protein) targeting radioactive probe that can be used as a tracer for PET imaging and tumor targeting.
DOTA-ALB-01 V119240 DOTA-ALB-01 DOTA-ALB-01 is an albumin-bound FAP inhibitor (FAPI) ligand.
DOTA-ALB-02 V119214 DOTA-ALB-02 DOTA-ALB-02 is an albumin-bound FAP inhibitor (FAPI) ligand.
DOTAGA.(SA.FAPi)2 analogue TFA V93849 DOTAGA.(SA.FAPi)2 analogue TFA DOTAGA.(SA.FAPi)2 analog TFA is an analog of DOTAGA.(SA.FAPi)2 TFA, wherein the ligand and chelator moieties are the same as DOTAGA.(SA.FAPi)2 TFA.
DOTAGA.(SA.FAPi)2 TFA V94503 DOTAGA.(SA.FAPi)2 TFA DOTAGA.(SA.FAPi)2 TFA is a potent inhibitor of dimeric fibroblast activation protein (FAPi).
FAP-IN-1 V79388 FAP-IN-1 2956858-96-9 FAP-IN-1 is a fibroblast activation protein (FAP) inhibitor (antagonist) with IC50 of 3.3 nM.
FAP-IN-2 V74897 FAP-IN-2 2471983-20-5 FAP-IN-2 is an analogue of 99mTc-labeled isonitrile-containing fibroblast activation protein (FAPI) inhibitor that can be used for tumor imaging.
FAP-IN-2 TFA V77022 FAP-IN-2 TFA FAP-IN-2 TFA is an analogue of 99mTc-labeled isonitrile-containing FAP inhibitor that can be used for tumor imaging.
FAP-IN-4 V86845 FAP-IN-4 FAP-IN-4 (Comp 10) is a fibroblast activation protein (FAP) inhibitor and a 18F-labeled PET tracer targeting FAP.
FAP-IN-7 V118521 FAP-IN-7 3020777-28-7 FAP-IN-7 (compound 5b) is an FAP inhibitor.
FAP-IN-8 V115930 FAP-IN-8 3075119-33-1 FAP-IN-8 (compound 12i) is a potent PREP and FAP inhibitor with pIC50 values of 8.99 and 10.08 for FAP and PREP, respectively, and IC50 values of 1 nM and 0.08 nM, respectively.
FAP6-19 V115247 FAP6-19 3095069-75-0 FAP6-19 is a radioligand that targets fibroblast activator protein (FAP) with a dissociation constant (Kd) of 18.2 nM.
FAPI-2 V74893 FAPI-2 2370952-98-8 FAPI-2 is a fibroblast activation protein (FAP) inhibitor that has applications in cancer-related research.
FAPI-2 TFA V77023 FAPI-2 TFA FAPI-2 TFA is a fibroblast activation protein (FAP) inhibitor (antagonist) with potential use in cancer-related research.
FAPI-34 V74894 FAPI-34 2374782-07-5 FAPI-34 is a fibroblast activating protein (FAP) inhibitor (antagonist) with good pharmacokinetic and biochemical properties, disclosed in patent WO2019154886A1.
FAPI-46 V51734 FAPI-46 2374782-04-2 FAPI-46 is a quinoline-based activator of fibroblast-activated protein (FAP).
FAPI-74 V74898 FAPI-74 2374782-76-8 FAPI-74 is a PET (positron emission tomography) tracer for fibroblast activating protein.
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