Monopolar spindle 1 (Mps1/TTK) is a serine/threonine kinase conserved from yeast to human.It has been demonstrated that it serves as the essential kinase that triggers the spindle assembly checkpoint (SAC) to ensure that chromosomes are distributed properly to daughter cells.

One of the key elements of the SAC is MPS1, a dual specificity protein kinase that prevents cells from transitioning from metaphase to anaphase until the kinetochores are correctly attached to the microtubules and under the proper tension at the metaphase plate. In order to handle aneuploidy, which is brought on by abnormally high or low chromosome numbers, cancer cells heavily rely on MPS1. Numerous tumor types have been found to have the kinase upregulated. Due to Mps1's high level of expression in cancer cells and the relationship between these levels and the histological grades of cancers, it is a desirable oncology target.

Mps1 related products

Structure Cat No. Product Name CAS No. Product Description
BAY1217389 V4195 BAY1217389 1554458-53-5 BAY 1217389 (BAY-1217389) is a novel, potent, orally bioavailable and selective inhibitor of the serine/threonine kinase monopolar spindle 1 (MPS1) (IC50< 10 nM) with potential cancer activity by selectively binding to and inhibiting the activity of Mps1.
Empesertib (BAY-1161909) V4204 Empesertib (BAY-1161909) 1443763-60-7 Empesertib (also known as BAY 1161909) is a novel, potent, orally bioavailable, and selective inhibitor of serine/threonine kinase Mps1 (monopolar spindle 1)with an IC50 of < 1 nM.
Mps1-IN-1 V33820 Mps1-IN-1 1125593-20-5 Mps1-IN-1 is a novel, ATP-competitive, selective and potent Mps1 kinase inhibitor with antitumor activity.
Mps1-IN-2 V33496 Mps1-IN-2 1228817-38-6 Mps1-IN-2 is a novel,ATP-competitive and potent Mps1 (monopolar spindle)/Plk1(Polo Like Kinase 1) inhibitor with potential anticancer activity.
Mps1-IN-4 V54367 Mps1-IN-4 1263423-94-4 Mps1-IN-4 is a selective Monopolar spindle 1 (Mps1) inhibitor (antagonist) with antiproliferation activity for cancer research.
Mps1-IN-6 V77916 Mps1-IN-6 Mps1-IN-6 is a potent Mps1 inhibitor (antagonist) with IC50 of 2.596 nM.
Mps1-IN-8 V84882 Mps1-IN-8 2259843-95-1
TC-Mps1-12 V15935 TC-Mps1-12 1206170-62-8 TC-Mps1-12 is a novel, selective and potent monopolar spindle 1 (Mps1) inhibitor with anticancer activity.
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