A family of Ca2+/calcineurin-dependent transcription factors known as nuclear factor of activated T cells (NFAT) proteins was first discovered as an inducible nuclear factor that could bind the interleukin-2 (IL-2) promoter in activated T cells.However, it was discovered that the NFAT family proteins were expressed outside of T cells after all of them had been isolated and molecularly characterized. In a variety of organs, including the central nervous system, blood vessels, heart, kidney, bone, skeletal muscle, and haematopoietic stem cells, recent research has revealed new regulatory roles for NFAT proteins. For instance, the vessel wall cells exhibit a variety of Ca2+ signaling modalities that can alter during disease. Potential regulators of vascular pathogenesis are NFAT proteins, which can decode and translate these signals into alterations in gene expression.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75193 | (+)-Syringaresinol ((+)-Syringaresinol) | 21453-69-0 | (+)-Syringaresinol, a lignan, is an inhibitor (blocker/antagonist) of NFAT transcription factor with IC50 of 329.4 μM. |
|
V121161 | (-)-γ-Cuparenol | 1357469-94-3 | (-)-γ-Cuparenol is a sesquiterpene compound with an IC50 value of 23.6 μg/mL for porcine Na+/K+-ATPase. |
|
V75195 | 11R-VIVIT (Cell permeable NFAT inhibitor) | 592517-80-1 | 11R-VIVIT is an inhibitor (blocker/antagonist) of nuclear factor of cell permeability for activated T cells (NFAT). |
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V123077 | 11R-VIVIT TFA | 11R-VIVIT TFA is a membrane-penetrating inhibitor of activated T cell nuclear factor (NFAT). | |
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V77334 | 11R-VIVIT | 592517-80-1 | 11R-VIVIT TFA is a nuclear factor of cell permeability (NFAT) inhibitor of activated T cells. |
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V126475 | 4-M-HMBPP | 4-M-HMBPP is a weak agonist of Vγ9Vδ2 T cell activation and a potent competitive inhibitor of HMBPP. | |
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V75192 | Gomisin E | 72960-21-5 | Gomisin E, a lignan extracted from Schisandra chinensis fruit, inhibits NFAT transcription with IC50 of 4.73 μM. |
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V86937 | HMBPP | 396726-03-7 | HMBPP (E-4-Hydroxy-3-methyl-but-2-enyl diphosphate) is an activator of human Vγ9/Vδ2 T cells. |
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V75190 | INCA-6 (Triptycene-1,4-quinone) | 3519-82-2 | INCA-6 (Triptycene-1,4-quinone) is a cell-permeable (penetrable) NFAT inhibitor. |
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V75191 | KRM-III | 79220-94-3 | KRM-III is a potent orally bioactive T cell antigen receptor (TCR) inhibitor. |
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V86938 | NFAT Inhibitor-3 | 841210-82-0 | NFAT Inhibitor-3 (Compound 10) is an inhibitor of nuclear factor of activated T cells (NFAT). |
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V75194 | Q134R | 2022949-46-6 | Q134R, a neuro-protection hydroxyquinoline analogue, inhibits nuclear factor of activated T cells (NFAT) signaling. |
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V40415 | Cyclosporin D | 63775-96-2 | Cyclosporin D is a nonpolar cyclic oligopeptide and a novel metabolite of Cyclosporin A, which is an immunosuppressant agentthat binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells. |
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