Adenosine deaminase (ADA) is an enzyme of the purine metabolism that catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. It has been discovered that a wide range of microorganisms, plants, and invertebrates all contain this universal enzyme. Additionally, it is found in every mammalian cell and is essential for the development of the lymphoid system. Humans have two different adenosine deaminases, called ADA1 and ADA2. A severe combined immunodeficiency is caused by inherited mutations in ADA1, which play a significant role in lymphocyte function. The novel family of adenosine deaminase growth factors (ADGFs), which are crucial for tissue development, includes ADA2.
ADA is important in a number of diseases. It's interesting to note that diseases can arise from both genetic ADA deficiency and ADA overexpression. The idea that inherited genetic ADA deficiency accounts for 15% of all cases of severe combined immunodeficiency disease (SCID) and is the primary cause of SCID is widely accepted. On the other hand, hemolytic anemia, liver cancer, breast cancer, etc. may all have a close connection to ADA overexpression.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V72980 | 8-Azaadenosine | 10299-44-2 | 8-Azaadenosine is a potent ADAR1 inhibitor. |
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V78727 | AMPD2 inhibitor 2 | AMPD2 inhibitor 2 (compound 21) is a potent AMP deaminase 2 (AMPD2) inhibitor (antagonist) with IC50s of 0.1 μM and 0.28 μM for hAMPD2 and mAMPD2, respectively. | |
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V4232 | Hibifolin | 55366-56-8 | Hibifolin is a novel and potent flavonol glycoside derived from herbal plants, it possessed a strong protective activity against cell death induced by aggregated Aβ. |
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V72982 | L-Adenosine (L-adenosine) | 3080-29-3 | L-Adenosine is a metabolically stable enantiomeric analogue and a potential probe. |
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V5214 | Pentostatin (CI825; Deoxycoformycin) | 53910-25-1 | Pentostatin (CI-825; Deoxycoformycin), a purine analog and an anticancer of the antimetabolite class, is an irreversible inhibitor of adenosine deaminase with Kiof 2.5 pM. |
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