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HSP

HSP

Heat shock proteins (HSPs) are a class of functionally related proteins that are involved in the folding and unfolding of other proteins. HSPs are a group of proteins that are produced in response to heat shock. When cells are subjected to high temperatures or other stresses, HSP expression rises. This increase in expression is controlled by transcription. Heat shock factor (HSF) is primarily responsible for the dramatic upregulation of the heat shock proteins, which is a crucial component of the heat shock response. Nearly every living thing, from bacteria to people, contains HSPs. Heat shock proteins seem to play a big part in the cardiovascular system. There have been reports of the roles of Hsp90, Hsp84, Hsp70, Hsp27, Hsp20, and alpha B crystallin in the cardiovasculature.

HSP related products

Structure Cat No. Product Name CAS No. Product Description
17-DMAP-GA V55770 17-DMAP-GA 169521-68-0 17-DMAP-GA, an analog of Geldanamycin, is an HSP90 inhibitor and can cause cell cycle abnormalities.
3-Phenyltoxoflavin V52504 3-Phenyltoxoflavin 32502-63-9 3-Phenyltoxoflavin is an analogue of Toxoflavin and an Hsp90 inhibitor.
[Au(TPP)]Cl V89622 [Au(TPP)]Cl 15695-27-9 [Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and has anticancer activity.
AlF-NOTA-c-d-VAP V88684 AlF-NOTA-c-d-VAP AlF-NOTA-cd-VAP is a peptide positron emission tomography (PET) probe for targeted tumor imaging of GRP78.
AP-4-139B V88685 AP-4-139B 2716909-84-9 AP-4-139B is a heat shock protein 70 (HSP70) inhibitor (IC50=180 nM).
Arimoclomol citrate (BRX-220 citrate) V55768 Arimoclomol citrate (BRX-220 citrate) 368860-21-3 Arimoclomol citrate (BRX-220 citrate) is a heat shock protein (HSP) co-inducer.
AT-533 V50992 AT-533 908112-37-8 AT-533 is a novel inhibitor of Hsp90 and HSV.
C086 V98845 C086 1160107-44-7 C086 is a novel and potent Hsp90 inhibitor that inhibits cell cycle progression, induces apoptosis, and exerts anti-metastatic effects by regulating various mechanisms in different cell types.
Cemdomespib (KU-596) V56157 Cemdomespib (KU-596) 1450642-92-8 Cemdomespib (KU-596) is a potent second-generation Hsp90 modulator.
DDO-5936 V52194 DDO-5936 2355377-13-6 DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor.
DTHIB V2264 DTHIB 897326-30-6 DTHIB is a direct and selective inhibitor of heat shock factor 1 (HSF1).
Eupalinolide A (野马追内酯A) V52915 Eupalinolide A (Eupalinolide A) 877822-40-7 Eupalinolide A, extracted from Eupatorium lindleyanum, activates HSF1 and induces the expression of HSP70 by inhibiting the interaction between HSF1 and HSP90.
EV206 V93418 EV206 2247047-81-8 EV206 is a potent Hsp70 inhibitor.
Geldanamycin-FITC V51969 Geldanamycin-FITC 2969156-01-0 Geldanamycin-FITC is a fluorescent probe of geldanamycin that can be used for fluorescence polarization analysis of HSP90 inhibitors.
gp96-II V98961 gp96-II Gp96-II is a gp96-blocking peptide that antagonizes gp96-mediated LPS-induced cytokine production.
GRP78-IN-3 V52041 GRP78-IN-3 2707510-30-1 GRP78-IN-3 is a selective Grp78 (HSPA5) inhibitor (antagonist) with IC50 of 0.59 μM.
Grp94 Inhibitor-2 V99872 Grp94 Inhibitor-2 Grp94 inhibitor-2 (compound 23) is a cyclopropane analogue with high affinity for glucose-regulated protein 94 (Grp94), with Kd of 0.48 µM and 0.65 µM for Grp94 and Hsp90α, respectively.
HA15-Biotin V52020 HA15-Biotin 1965310-52-4 HA15-Biotin is a chemical probe consisting of HA15 and biotin attached to the amide moiety of HA15.
HM03 V2212 HM03 500565-15-1 HM03 (HM-03) is a novel, potent and selective HSPA5 (also known as Heat shock 70kDa protein 5, Bip, Grp78) inhibitor with anticancer activity.
HM03 trihydrochloride V51978 HM03 trihydrochloride 1082532-95-3 HM03 tri HCl is a potent and specific inhibitor of heat shock 70 kDa protein 5, HSPA5 (also known as Bip, Grp78) with anti-tumor activity.
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