Heat shock proteins (HSPs) are a class of functionally related proteins that are involved in the folding and unfolding of other proteins. HSPs are a group of proteins that are produced in response to heat shock. When cells are subjected to high temperatures or other stresses, HSP expression rises. This increase in expression is controlled by transcription. Heat shock factor (HSF) is primarily responsible for the dramatic upregulation of the heat shock proteins, which is a crucial component of the heat shock response. Nearly every living thing, from bacteria to people, contains HSPs. Heat shock proteins seem to play a big part in the cardiovascular system. There have been reports of the roles of Hsp90, Hsp84, Hsp70, Hsp27, Hsp20, and alpha B crystallin in the cardiovasculature.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V55770 | 17-DMAP-GA | 169521-68-0 | 17-DMAP-GA, an analog of Geldanamycin, is an HSP90 inhibitor and can cause cell cycle abnormalities. |
|
V52504 | 3-Phenyltoxoflavin | 32502-63-9 | 3-Phenyltoxoflavin is an analogue of Toxoflavin and an Hsp90 inhibitor. |
|
V7250 | Alvespimycin | 467214-20-6 | Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor that binds to Hsp90 with EC50 of 62 ± 29 nM. |
|
V55768 | Arimoclomol citrate (BRX-220 citrate) | 368860-21-3 | Arimoclomol citrate (BRX-220 citrate) is a heat shock protein (HSP) co-inducer. |
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V6051 | Arimoclomol maleate | 289893-26-1 | Arimoclomol, formerly known as BRX-220, is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). |
|
V50992 | AT-533 | 908112-37-8 | AT-533 is a novel inhibitor of Hsp90 and HSV. |
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V56157 | Cemdomespib (KU-596) | 1450642-92-8 | Cemdomespib (KU-596) is a potent second-generation Hsp90 modulator. |
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V52194 | DDO-5936 | 2355377-13-6 | DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. |
|
V2264 | DTHIB | 897326-30-6 | DTHIB is a direct and selective inhibitor of heat shock factor 1 (HSF1). |
|
V52915 | Eupalinolide A (Eupalinolide A) | 877822-40-7 | Eupalinolide A, extracted from Eupatorium lindleyanum, activates HSF1 and induces the expression of HSP70 by inhibiting the interaction between HSF1 and HSP90. |
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V51969 | Geldanamycin-FITC | 2969156-01-0 | Geldanamycin-FITC is a fluorescent probe of geldanamycin that can be used for fluorescence polarization analysis of HSP90 inhibitors. |
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V52041 | GRP78-IN-3 | 2707510-30-1 | GRP78-IN-3 is a selective Grp78 (HSPA5) inhibitor (antagonist) with IC50 of 0.59 μM. |
|
V52020 | HA15-Biotin | 1965310-52-4 | HA15-Biotin is a chemical probe consisting of HA15 and biotin attached to the amide moiety of HA15. |
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V2212 | HM03 | 500565-15-1 | HM03 (HM-03) is a novel, potent and selective HSPA5 (also known as Heat shock 70kDa protein 5, Bip, Grp78) inhibitor with anticancer activity. |
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V51978 | HM03 trihydrochloride | 1082532-95-3 | HM03 tri HCl is a potent and specific inhibitor of heat shock 70 kDa protein 5, HSPA5 (also known as Bip, Grp78) with anti-tumor activity. |
|
V51972 | HS-131 | 2084850-40-6 | HS-131 is a near-infrared dye inhibitor of Hsp90 that can detect proto-oncogene-driven breast cancer and identify different molecular subtypes of human breast cancer. |
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V80313 | HSP70/SIRT2-IN-1 | HSP70/SIRT2-IN-1 (Compounds 2a) is a dual (bifunctional) inhibitor of SIRT2 and HSP70 with IC50 of 17.3±2.0 μM. | |
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V55780 | Hsp90-IN-17 | 1253584-78-9 | Hsp90-IN-17 (Example 5) is an HSP90 inhibitor that may be utilized in the study of proliferative diseases such as cancer and neurodegenerative diseases. |
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V53042 | Hsp90-IN-17 hydrochloride | 1253584-63-2 | Hsp90-IN-17 (Example 5) HCl is an HSP90 inhibitor that may be utilized in the study of proliferative diseases such as cancer and neurodegenerative diseases. |
|
V78812 | HSP90-IN-18 | HSP90-IN-18 is a potent heat shock protein 90 (Hsp90) inhibitor. |
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