Heat shock proteins (HSPs) are a class of functionally related proteins that are involved in the folding and unfolding of other proteins. HSPs are a group of proteins that are produced in response to heat shock. When cells are subjected to high temperatures or other stresses, HSP expression rises. This increase in expression is controlled by transcription. Heat shock factor (HSF) is primarily responsible for the dramatic upregulation of the heat shock proteins, which is a crucial component of the heat shock response. Nearly every living thing, from bacteria to people, contains HSPs. Heat shock proteins seem to play a big part in the cardiovascular system. There have been reports of the roles of Hsp90, Hsp84, Hsp70, Hsp27, Hsp20, and alpha B crystallin in the cardiovasculature.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V55770 | 17-DMAP-GA | 169521-68-0 | 17-DMAP-GA, an analog of Geldanamycin, is an HSP90 inhibitor and can cause cell cycle abnormalities. |
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V52504 | 3-Phenyltoxoflavin | 32502-63-9 | 3-Phenyltoxoflavin is an analogue of Toxoflavin and an Hsp90 inhibitor. |
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V89622 | [Au(TPP)]Cl | 15695-27-9 | [Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and has anticancer activity. |
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V88684 | AlF-NOTA-c-d-VAP | AlF-NOTA-cd-VAP is a peptide positron emission tomography (PET) probe for targeted tumor imaging of GRP78. | |
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V88685 | AP-4-139B | 2716909-84-9 | AP-4-139B is a heat shock protein 70 (HSP70) inhibitor (IC50=180 nM). |
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V55768 | Arimoclomol citrate (BRX-220 citrate) | 368860-21-3 | Arimoclomol citrate (BRX-220 citrate) is a heat shock protein (HSP) co-inducer. |
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V50992 | AT-533 | 908112-37-8 | AT-533 is a novel inhibitor of Hsp90 and HSV. |
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V98845 | C086 | 1160107-44-7 | C086 is a novel and potent Hsp90 inhibitor that inhibits cell cycle progression, induces apoptosis, and exerts anti-metastatic effects by regulating various mechanisms in different cell types. |
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V56157 | Cemdomespib (KU-596) | 1450642-92-8 | Cemdomespib (KU-596) is a potent second-generation Hsp90 modulator. |
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V52194 | DDO-5936 | 2355377-13-6 | DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. |
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V2264 | DTHIB | 897326-30-6 | DTHIB is a direct and selective inhibitor of heat shock factor 1 (HSF1). |
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V52915 | Eupalinolide A (Eupalinolide A) | 877822-40-7 | Eupalinolide A, extracted from Eupatorium lindleyanum, activates HSF1 and induces the expression of HSP70 by inhibiting the interaction between HSF1 and HSP90. |
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V93418 | EV206 | 2247047-81-8 | EV206 is a potent Hsp70 inhibitor. |
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V51969 | Geldanamycin-FITC | 2969156-01-0 | Geldanamycin-FITC is a fluorescent probe of geldanamycin that can be used for fluorescence polarization analysis of HSP90 inhibitors. |
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V98961 | gp96-II | Gp96-II is a gp96-blocking peptide that antagonizes gp96-mediated LPS-induced cytokine production. | |
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V52041 | GRP78-IN-3 | 2707510-30-1 | GRP78-IN-3 is a selective Grp78 (HSPA5) inhibitor (antagonist) with IC50 of 0.59 μM. |
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V99872 | Grp94 Inhibitor-2 | Grp94 inhibitor-2 (compound 23) is a cyclopropane analogue with high affinity for glucose-regulated protein 94 (Grp94), with Kd of 0.48 µM and 0.65 µM for Grp94 and Hsp90α, respectively. | |
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V52020 | HA15-Biotin | 1965310-52-4 | HA15-Biotin is a chemical probe consisting of HA15 and biotin attached to the amide moiety of HA15. |
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V2212 | HM03 | 500565-15-1 | HM03 (HM-03) is a novel, potent and selective HSPA5 (also known as Heat shock 70kDa protein 5, Bip, Grp78) inhibitor with anticancer activity. |
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V51978 | HM03 trihydrochloride | 1082532-95-3 | HM03 tri HCl is a potent and specific inhibitor of heat shock 70 kDa protein 5, HSPA5 (also known as Bip, Grp78) with anti-tumor activity. |