MTHFD

MTHFD

Methylenetetrahydrofolate dehydrogenase (MTHFD) is an essential enzyme in the folate-dependent one-carbon metabolism, which is crucial for the biosynthesis of a number of amino acids, including glycine, alanine, and serine, as well as nucleotide bases, formylated methionine, and some pro-vitamins. MTHFD, also known as FolD in this species, is a dual function enzyme found in some bacteria, including E. coli, that catalyzes the conversion of 5,10-methylenetetrahydrofolate and NADP+ to 5,10-methenyltetrahydrofolate and NADPH (dehydrogenase function) and then the first product to 10-formyltetrahydrofolate (cyclohydrolase function). Some microorganisms have a separate enzyme (FchA) that catalyzes the second cyclohydrolase function, and some species have a different pathway that uses formyltetrahydrofolate synthetase (Fhs) to produce 10-formyltetrahydrofolate. MTHFD is a crucial anticancer therapy target in eukaryotes.

MTHFD related products

Structure Cat No. Product Name CAS No. Product Description
V4845 LY-345899 10538-99-5 LY345899 is a novel, potent inhibitor of cytoplasmic and mitochondrial methylenetetrahydrofolate dehydrogenase MTHFD1 and MTHFD2 inhibitor with aKiof 0.018 μM.
V79096 MTHFD2-IN-1 MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2).
V79479 MTHFD2-IN-2 MTHFD2-IN-2 (compound 13) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2).
V79471 MTHFD2-IN-3 MTHFD2-IN-3 (compound 10) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2).
V80848 MTHFD2-IN-4 MTHFD2-IN-4 is a tricyclic coumarin analogue and a potent inhibitor of MTHFD2.
V80849 MTHFD2-IN-4 sodium MTHFD2-IN-4 sodium is a tricyclic coumarin analogue and a potent MTHFD2 inhibitor.
V83626 TH9619 2379556-22-4
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