Methylenetetrahydrofolate dehydrogenase (MTHFD) is an essential enzyme in the folate-dependent one-carbon metabolism, which is crucial for the biosynthesis of a number of amino acids, including glycine, alanine, and serine, as well as nucleotide bases, formylated methionine, and some pro-vitamins. MTHFD, also known as FolD in this species, is a dual function enzyme found in some bacteria, including E. coli, that catalyzes the conversion of 5,10-methylenetetrahydrofolate and NADP+ to 5,10-methenyltetrahydrofolate and NADPH (dehydrogenase function) and then the first product to 10-formyltetrahydrofolate (cyclohydrolase function). Some microorganisms have a separate enzyme (FchA) that catalyzes the second cyclohydrolase function, and some species have a different pathway that uses formyltetrahydrofolate synthetase (Fhs) to produce 10-formyltetrahydrofolate. MTHFD is a crucial anticancer therapy target in eukaryotes.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4845 | LY-345899 | 10538-99-5 | LY345899 is a novel, potent inhibitor of cytoplasmic and mitochondrial methylenetetrahydrofolate dehydrogenase MTHFD1 and MTHFD2 inhibitor with aKiof 0.018 μM. |
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V79096 | MTHFD2-IN-1 | MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2). | |
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V79479 | MTHFD2-IN-2 | MTHFD2-IN-2 (compound 13) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2). | |
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V79471 | MTHFD2-IN-3 | MTHFD2-IN-3 (compound 10) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2). | |
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V80848 | MTHFD2-IN-4 | MTHFD2-IN-4 is a tricyclic coumarin analogue and a potent inhibitor of MTHFD2. | |
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V80849 | MTHFD2-IN-4 sodium | MTHFD2-IN-4 sodium is a tricyclic coumarin analogue and a potent MTHFD2 inhibitor. | |
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V96672 | TH9028 | 2379556-15-5 | TH9028 is a MTHFD2 inhibitor (IC50 = 11 nM), with IC50 values of 7.97 nM, 27 nM, and 0.5 nM for hMTHFD2, MTHFD2L, and MTHFD1, respectively. |
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V83626 | TH9619 | 2379556-22-4 |
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