nAChR

nAChR

Nicotinic acetylcholine receptors, or nAChRs, are proteins on neurons that signal when a chemical stimulus causes muscles to contract. On the presynaptic and postsynaptic sides of the neuromuscular junction, as well as in the plasma membranes of some neurons, they are cholinergic receptors that create ligand-gated ion channels. The most extensively researched ionotropic receptors are those for nicotinic acetylcholine. The neurotransmitter acetylcholine (ACh) binds to the nAChR, just like it does with the other type of acetylcholine receptor, the muscarinic acetylcholine receptor (mAChR). Nicotinic receptors can be opened by both acetylcholine and nicotine, hence the name "nicotinic," just as muscarinic receptors are so named because they are also activated by muscarine.

nAChR related products

Structure Cat No. Product Name CAS No. Product Description
V77398 (+)-Sparteine sulfate pentahydrate ((+)-Lupinidine sulfate pentahydrate) (+)-sparteine (sulfate pentahydrate) is a ganglionic blocker.
V31453 (-)-(S)-B-973B 2244989-34-0 (-)-(S)-B-973B is a potent positive allosteric modulator (PAM) of α7 nAChR and may be utilized in pain relief research.
V84388 (-)-Coclaurine hydrochloride ((-)-(S)-Coclaurine hydrochloride; (S)-Coclaurine hydrochloride; l-Coclaurine hydrochloride) 3422-42-2
V70730 (-)-Sparteine sulfate ((-)-Sparteine sulfate) 299-39-8 (-)-Sparteine (sulfate) is a quinolizidine alkaloid that can be found in Lupinus.
V70720 (Rac)-CP-601927 hydrochloride 230615-01-7 (Rac)-CP-601927 HCl is the racemate of CP-601927.
V70763 (rel)-Asperparaline A ((rel)-Aspergillimide; (rel)-VM55598) 195966-93-9 (rel)-Asperparaline A ((rel)-Aspergillimide) is an anthelmintic metabolite extracted from okara fermented by Aspergillus japonicas JV-23.
V70753 (S)-UFR2709 1431628-22-6 (S)-UFR2709 is a competitive nAChR antagonist and shows stronger affinity to α4β2 nAChR than to α7 nAChR.
V70714 (S)-UFR2709 hydrochloride 2934318-93-9 (S)-UFR2709 ( HCl) is a competitive nAChR antagonist and shows stronger affinity for α4β2 nAChR than for α7 nAChR.
V77354 (S)-VQW-765 ((S)-AQW-051) (S)-VQW-765 ((S)-AQW-051) is an orally bioactive, selective, and potent partial agonist of the α7 nicotinic Ach receptor (nAChR).
V70719 (±)-Anatoxin A fumarate 1219922-30-1 (±)-Anatoxin A fumarate is a naturally occurring alkaloid extracted from freshwater cyanobacteria.
V70767 (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) 15991-59-0 (±)-Coniine HCl (2-Propylpiperidine HCl) is a potent nAChR agonist/activator with EC50 of 0.3 mM.
V70781 3-Pyr-Cytisine (3-Pyr-Cyt) 948027-43-8 3-Pyr-Cytisine (3-pyr-Cyt) is a cytisine analogue.
V70750 5-AAM-2-CP 175424-74-5 5-AAM-2-CP is a major metabolite of Acetamiprid.
V70758 5-AMAM-2-CP 864628-19-3 5-AMAM-2-CP is a major metabolite of Acetamiprid.
V70775 5-Iodo-A-85380 dihydrochloride (5-I A-85380 dihydrochloride) 1217837-17-6 5-Iodo-A-85380 di-HCl is a selective ligand for nAChR.
V85143 8-Aminoadenine 28128-33-8
V70706 A-582941 dihydrochloride 848591-90-2 A-582941 di-HCl is a specific and BBB (blood-brain barrier) permeable (penetrable) partial agonist of α7 nAChR with Kis of 10.8 nM and 16.7 nM in rat meninges and human frontal cortex, respectively.
V70711 ABT-107 855291-54-2 ABT-107 is a selective agonist of α7 neuronal nicotine receptors.
V70729 ACV1 (Vc1.1) 740980-24-9 ACV1 (Vc1.1) is an α-conotoxin and a selective α9α10 nAChR antagonist (inhibitor) with IC50 of 19 nM.
V70751 Anabaseine (pseudoequisetine) 3471-05-4 Anabaseine is a non-selective nicotinic receptor agonist.
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