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PAFR

PAFR

The platelet-activating factor receptor (PAFR) is a G-protein-coupled receptor involved in a wide variety of pathophysiological processes in addition to normal physiological ones. Platelet-activating factor (PAF), a phospholipid mediator of cell-to-cell communication with a variety of physiological effects, is what causes PAFR to react. Platelet-activating factor (PAF) binding stimulates the PAFR, which results in a variety of powerful biological activities and has a significant impact on anaphylaxis, endotoxic shock, allergic disorders, and acute inflammation. PAF, a strong and adaptable mediator of inflammation, is produced by a variety of cell types and tissues, but leukocytes in particular.

PAFR related products

Structure Cat No. Product Name CAS No. Product Description
2-O-Ethyl PAF C-16 V84253 2-O-Ethyl PAF C-16 78858-42-1
Carbamyl-PAF (C-PAF) V84332 Carbamyl-PAF (C-PAF) 91575-58-5
CP-96021 V86649 CP-96021 139401-43-7 CP-96021 is a highly effective, orally available leukotriene D4 (LTD4 Ki=34 μM) / platelet activating factor (PAF Ki=37 μM) receptor antagonist.
Hexanolamino PAF C-16 (1-O-Hexa-decyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)-hexanolamine) V84196 Hexanolamino PAF C-16 (1-O-Hexa-decyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)-hexanolamine) 137566-83-7
Homoeriodictyol 7-O-β-D-glucoside V74452 Homoeriodictyol 7-O-β-D-glucoside 14982-11-7 Homoeriodictyol 7-O-β-D-glucoside is a natural platelet-activating factor (PAF) antagonist.
Kadsurenin B V74453 Kadsurenin B 145701-13-9 Kadsurenin B is a PAF (platelet-activating factor) antagonist (inhibitor) with neuro-protection activity.
Kadsurenolone V74451 Kadsurenolone 95851-37-9 Kadsurenone is a lignan with specific antagonistic activity of platelet-activating factor.
Kadsurin A V74450 Kadsurin A 99340-07-5 Kadsurin A is a new lignan extracted from Piper futokadsura.
NVP-TNKS656 V1494 NVP-TNKS656 1419949-20-4 NVP-TNKS656 (also called TNKS-656; NVP-TNKS-656; TNKS 656; NVP-TNKS 656) is a selective, and orally bioactive tankyrase inhibitor with potential antitumor activity.
PAF (C18) V84288 PAF (C18) 74389-69-8
Pinusolidic acid V74455 Pinusolidic acid 40433-82-7 Pinusolidic Acid is a platelet activating factor (PAF) inhibitor (antagonist) with IC50 of 23 μM.
Piperulin A V74456 Piperulin A 164268-04-6 Piperulin A is a potent PAFR inhibitor.
Pregomisin V74454 Pregomisin 66280-26-0 Pregomisin is a natural compound extracted from the fruit of Schisandra chinensis.
α-Bulnesene V86725 α-Bulnesene 3691-11-0 α-Bulnesene is a novel PAF receptor antagonist with an IC50 value of 17.62 μM.
银杏内酯B V1493 Ginkgolide B (BN-52021) 15291-77-7 Ginkgolide B (Bilobalide B; BN-52051; BN52051) is a naturally occuring compound acting as a PAFR (platelet-activating factor receptor) antagonist with an IC50 of 3.6 μM.
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