| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V32687 | BC-1215 | 1507370-20-8 | BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). |
|
V4877 | CC-885 | 1010100-07-8 | CC-885 (CC885) is a novel and potent cereblon (CRBN) modulator with potent antitumour activity, it acts bythe degradation of GSPT1 and was demonstrated to mediate antitumor effects through the recruitment and degradation of G1 to S phase transition 1 protein (GSPT1). |
|
V132170 | CRBN ligand-12 | 2820501-20-8 | CRBN ligand-12 is a CRBN-type E3 ubiquitin ligase ligand. |
|
V132519 | CST530 | 847137-53-5 | CST530 is an inhibitor of apoptosis protein (IAP) antagonist. |
|
V5267 | Eragidomide (CC-90009) | 1860875-51-9 | CC-90009 (CC90009; Eragidomide) is a novel and potent modulator of cereblon (CRBN), which is part of the cullin 4-RING E3 ubiquitin ligase complex (CRL4-CRBN E3 ubiquitin ligase; CUL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and pro-apoptotic activities. |
|
V135207 | ErbB2 peptide | 325791-52-4 | ErbB2 peptide is a peptide ligand for E3 ubiquitin ligase that targets PI3K to form the peptide PROTAC. |
|
V5268 | Iberdomide (CC-220) | 1323403-33-3 | Iberdomide (also known as CC-220) is a novel and potent cereblon (CRBN) modulator with an IC50of 60 nM and can be potentially used for the treatment of systemic lupus erythematosus. |
|
V140421 | MRT-3486 | MRT-3486 is a molecular adhesive degrader. | |
|
V141209 | NEURL1B-IN-1 | 3068938-30-4 | NEURL1B-IN-1 is a molecular colloidal NEURL1B degrader with a Kd value of 46.2 nM. |
|
V143340 | PROTAC HDAC6 degrader 5 | PROTAC HDAC6 degrader 5 is a highly selective PROTAC inhibitor targeting HDAC6. | |
|
V0083 | PRT4165 (NSC-600157) | 31083-55-3 | PRT4165 (NSC600157) is a potentand selective inhibitor of the PRC1 (polycomb repressive complex 1)-mediated H2A ubiquitylation with potential anticancer activity. |
|
V3116 | Skp2 inhibitor C1 (SKPin C1) | 432001-69-9 | Skp2 inhibitor C1 (also known as SKPin C1) is a specific and selective small-molecule inhibitor ofSkp2-mediated p27 degradation,it selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. |
|
V145042 | SMARCA2 ligand-14 | SMARCA2 ligand-14 is a ligand of SMARCA2 and can be used to synthesize the PROTAC degrader SMD-3236. | |
|
V4432 | Smurf1-IN-A01 | 1007647-73-5 | Smurf1-IN-A01is a novel, potent, high affinity and selective inhibitor of E3 ubiquitin-protein ligase Smurf1 (Smad ubiquitination regulatory factor-1) with Kd value of 3.7 nM. |
|
V2952 | SZL P1-41 | 222716-34-9 | SZL P1-41 is aSkp2 inhibitor that phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. |
|
V146022 | Thalidomide-cyanine 5 | Thalidomide-cyanine 5 is a fluorescent probe composed of the CRBN binder thalidomide and the near-infrared fluorescent dye Cy5. | |
|
V28020 | VL285 | 1448188-57-5 | VL285 is a potent VHL ligand with IC50 of 0.34 μM. |
|
V2788 | Avadomide | 1015474-32-4 | Avadomide (formerly known as CC-122) is a novel, orally available pleiotropic pathway modulator with potential with anticancer and immunomodulatory activity. |
|
V3203 | Avadomide HCl | 1398053-45-6 | Avadomide HCl, the hydrochloride salt of Avadomide (formerly known as CC-122) with improved water solubility, is a novel, orally available pleiotropic pathway modulator with potential with anticancer and immunomodulatory activity. |
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