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E3 Ligase

E3 Ligase

E3 Ligase related products

Structure Cat No. Product Name CAS No. Product Description
Avadomide V2788 Avadomide 1015474-32-4 Avadomide (formerly known as CC-122) is a novel, orally available pleiotropic pathway modulator with potential with anticancer and immunomodulatory activity.
Avadomide HCl V3203 Avadomide HCl 1398053-45-6 Avadomide HCl, the hydrochloride salt of Avadomide (formerly known as CC-122) with improved water solubility, is a novel, orally available pleiotropic pathway modulator with potential with anticancer and immunomodulatory activity.
BC-1215 V32687 BC-1215 1507370-20-8 BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release).
CC-885 V4877 CC-885 1010100-07-8 CC-885 (CC885) is a novel and potent cereblon (CRBN) modulator with potent antitumour activity, it acts bythe degradation of GSPT1 and was demonstrated to mediate antitumor effects through the recruitment and degradation of G1 to S phase transition 1 protein (GSPT1).
Eragidomide (CC-90009) V5267 Eragidomide (CC-90009) 1860875-51-9 CC-90009 (CC90009; Eragidomide) is a novel and potent modulator of cereblon (CRBN), which is part of the cullin 4-RING E3 ubiquitin ligase complex (CRL4-CRBN E3 ubiquitin ligase; CUL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and pro-apoptotic activities.
Iberdomide (CC-220) V5268 Iberdomide (CC-220) 1323403-33-3 Iberdomide (also known as CC-220) is a novel and potent cereblon (CRBN) modulator with an IC50of 60 nM and can be potentially used for the treatment of systemic lupus erythematosus.
PRT4165 (NSC-600157) V0083 PRT4165 (NSC-600157) 31083-55-3 PRT4165 (NSC600157) is a potentand selective inhibitor of the PRC1 (polycomb repressive complex 1)-mediated H2A ubiquitylation with potential anticancer activity.
Skp2 inhibitor C1 (SKPin C1) V3116 Skp2 inhibitor C1 (SKPin C1) 432001-69-9 Skp2 inhibitor C1 (also known as SKPin C1) is a specific and selective small-molecule inhibitor ofSkp2-mediated p27 degradation,it selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.
Smurf1-IN-A01 V4432 Smurf1-IN-A01 1007647-73-5 Smurf1-IN-A01is a novel, potent, high affinity and selective inhibitor of E3 ubiquitin-protein ligase Smurf1 (Smad ubiquitination regulatory factor-1) with Kd value of 3.7 nM.
SZL P1-41 V2952 SZL P1-41 222716-34-9 SZL P1-41 is aSkp2 inhibitor that phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence.
VL285 V28020 VL285 1448188-57-5 VL285 is a potent VHL ligand with IC50 of 0.34 μM.
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