| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V3885 | Ivosidenib (AG-120) racemate | 1448346-63-1 | Ivosidenib racemate (AG120; RG120; AG-120; RG-120;Tibsovo), the racemic mixture ofIvosidenib, is an orally bioavailable andsmall moleculeIDH1 inhibitor that inhibits mutated cytosolic isocitrate dehydrogenase 1 (IDH1). |
![2H-四唑乙酸,5-[3-[4-(2-溴-5-氟苯氧基)-1-哌啶基]-5-异恶唑]-](http://www.invivochem.com/upload/0201/CgAGTF2LIhmAKuNKAAAu2VoOZSs056.png)
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V0856 | MK-8245 | 1030612-90-8 | MK-8245 (MK8245; MK 8245) is a novel and potentliver-targeted inhibitor of stearoyl-CoA desaturase (SCD) with anti-diabetic and anti-dyslipidemic activities. |
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V3151 | 3-Methylpyrazole | 1453-58-3 | 3-Methylpyrazole (also known as 3-MP) is a weak inhibitor ofalcohol dehydrogenase,which are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide (NAD+ to NADH). |
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V0855 | AGI-5198 | 1355326-35-0 | AGI-5198 (also know as IDH-C35; IDHC35; AGI-5198; AGI 5198) is a novel, highly potent and selective inhibitor of IDH1 (isocitrate dehydrogenase 1) R132H/R132C mutants with potential anticancer activity. |
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V0862 | AGI-6780 | 1432660-47-3 | AGI-6780 (AGI6780; AGI 6780) is a potent and selective inhibitor oftumor-associated mutant IDH2 (isocitrate dehydrogenases 2) R140Q with potential anti-inflammatory activity. |
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V11730 | ASP9521 | 1126084-37-4 | ASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). |
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V4174 | BAY-1436032 | 1803274-65-8 | BAY-1436032 is a novel and potent pan-mutant isocitrate dehydrogenase 1 (IDH1) inhibitor both in vitro and in vivo. |
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V16006 | BVT-2733 | 376640-41-4 | BVT-2733 is a selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, which attenuates obesity and inflammation in diet-induced obese mice. |
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V18887 | CVT-10216 | 1005334-57-5 | CVT-10216, an isoflavone compound, is a novel, highly potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) with IC50s of 29 and 1300 nM for ALDH2 and ALDH1, respectively. |
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V39998 | DHODH-IN-11 | 1263303-95-2 | DHODH-IN-11 (Compound 14b) is a Leflunomide analogue and a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with a pKa of 5.03. |
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V0858 | NCT-501 | 1802088-50-1 | NCT-501 (NCT501; NCT 501), a theophylline-based compound, is a novel, highly potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with potential anticancer activity. |
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V26321 | NCT-503 | 1916571-90-8 | NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 of 2.5 µM. |
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V4546 | R-GNE-140 | 2003234-63-5 | (R)-GNE-140, the S-enantiomer ofGNE-140, is a novel and potent lactate dehydrogenase (LDHA) inhibitor with potential anticancer activity. |
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V0857 | SW-033291 | 459147-39-8 | SW033291 (SW-033291; SW 033291) is a selective and high affinity inhibitor of the prostaglandin-degrading enzyme 15-PGD (15-hydroxyprostaglandin dehydrogenase) with potential kidney and liver protective effects. |
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V2766 | Vorasidenib | 1644545-52-7 | Vorasidenib (formerly known as AG-881; AG881) is a selective and orally bioavailable inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) with potential anticancer activity. |
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V0859 | Disulfiram | 97-77-8 | Disulfiram (Disulfan; NSC 190940;Dicupral; Disetil;NSC190940; Tetraethylthiuram disulfide; TETD)is a potent andspecific inhibitor of aldehyde-dehydrogenase (ALDH1) that is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. |
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V0866 | Gimeracil | 103766-25-2 | Gimeracil (chlorodihydroxypyridine; CDHP; Gimestat), a pyridine/pyridone analog and an approved anticancer drug, is a potent inhibitor of the dihydropyrimidine dehydrogenase (DPYD) enzyme with potential anti-neoplastic activity. |
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V5193 | Olutasidenib (FT2102) | 1887014-12-1 | Olutasidenib (FT-2102) is a novel, highly potent and selective small molecue inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1) with the potential to be used in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). |
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V17016 | Brequinar Sodium (DUP-785; NSC368390) | 96201-88-6 | Brequinar sodium (also known as DUP785;NSC-368390),a synthetic quinolinecarboxylic acid analog, is a novel and potent inhibitor ofdihydroorotate dehydrogenasewith potent activities against a broad spectrum of viruses andantineoplastic properties. |
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V5125 | Brequinar (DUP785; NSC 368390) | 96187-53-0 | Brequinar (formerly DUP-785; NSC-368390),a synthetic quinolinecarboxylic acid analog, is a novel and potent inhibitor ofdihydroorotate dehydrogenasewith potent activities against a broad spectrum of viruses andantineoplastic properties. |
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