The catecholamines, in particular norepinephrine and epinephrine, are targets of the G protein-coupled receptor class known as adrenergic receptors. These receptors are found on numerous cells, and when a catecholamine binds to one of these receptors, the sympathetic nervous system is typically stimulated. The fight-or-flight response is controlled by the sympathetic nervous system, which causes the eye pupils to dilate, the body to mobilize energy, and the blood supply to skeletal muscle to be diverted from non-essential organs.There are numerous subtypes of the two main groups of adrenergic receptors, and. The receptor subtypes 1 and 2 exist. There are three subtypes of receptors: 1, 2, and 3. They are all associated with Gs proteins, which are associated with adenylate cyclase. Thus, antagonist binding increases the level of the second messenger cAMP inside of the cell. The cAMP-dependent protein kinase (PKA), one of cAMP's downstream effectors, mediates some intracellular processes after hormone binding.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V1134 | Formoterol Hemifumarate | 43229-80-7 | Hemifumarate (CGP-25827A, NSC-299587, YM-08316; Eformoterol; Aformoterol; Atock; Foradil Aerolizer), the Hemifumarate salt of formoterol, is a selective and long-acting β2-adrenoceptor agonist with airway smooth muscle relaxing effects. |
|
V71269 | Formoterol-d3 | 1198353-13-7 | Formoterol-d3 is the deuterated form of Arformoterol. |
|
V71293 | Formoterol-d6 ((±)Formoterol-d6) | 1020719-45-2 | Formoterol-d6 is the deuterium labelled form of Formoterol. |
|
V1151 | Guanabenz Acetate (BR-750; Wy8678 acetate) | 23256-50-0 | Guanabenz Acetate (BR-750; Wy-8678; BR 750; Wy 8678; EIPA), the acetate salt of Guanabenz, is an agonist of α2a/b/c-adrenergic receptors with antihypertensive effects. |
|
V71296 | Guanfacine-13C,15N3 (Guanfacine-13C,15N3) | 1189924-28-4 | Guanfacine-13C,15N3 is 13C (carbon 13) and 15N (nitrogen 15) labelled Guanfacine. |
|
V71252 | Guanoxabenz hydrochloride (Hydroxyguanabenz hydrochloride) | 23256-40-8 | Guanoxabenz (Hydroxyguanabenz) HCl is an α2 adrenergic receptor agonist/activator with a Ki of 4000 nM and a Ki of α2A of 40 nM. |
|
V71311 | HEAT hydrochloride (BE2254 hydrochloride) | 30007-39-7 | HEAT (BE2254) HCl is a selective α1-adrenergic receptor antagonist. |
|
V22185 | Higenamine hydrochloride | 11041-94-4 | Higenamine HCl is a selective LSD1 inhibitor (IC50=1.47 μM) extracted from Aconitum. |
|
V22303 | Hydrocortisone butyrate | 13609-67-1 | Hydrocortisone butyrate (Cortisol 17-butyrate), the 17-butyl ester of Hydrocortisone, is a potent corticosteroid that has been used as antiinflammatory and immunosuppresive drug. |
|
V40207 | Hydroxybupropion | 92264-81-8 | Hydroxybupropion is a major metabolite of Bupropion (trade names Wellbutrin and Zyban) which is a marketed antidepressant and a smoking cessation drug. |
|
V71290 | ICI 89406 | 53671-71-9 | ICI 89406 is a selective β1 adrenergic receptor blocker (antagonist) and is suitable for PET labeling with positron emitters. |
|
V71319 | Imiloxan hydrochloride (RS 21361) | 81167-22-8 | Imiloxan HCl is a potent and specific alpha 2B-adrenergic receptor blocker (antagonist). |
|
V22533 | Indacaterol (Onbrez; Arcapta; QAB149) | 312753-06-3 | Indacaterol (formerly known as QAB-149)is an anti-COPD drug acting as an ultra-long-acting β-adrenoceptor agonist developed by Novartis with pKi of 7.36. |
|
V1100 | Indacaterol Maleate (QAB149) | 753498-25-8 | Indacaterol Maleate (formerly known as QAB149; QAB-149; Onbrez Breezhale; arcapta neohaler; Onbrez), the maleate salt of indacaterol, is an approved anti-COPD (chronic obstructive pulmonary disease) drug acting as an ultra-long-acting β-adrenoceptor agonist developed by Novartis. |
|
V1119 | Isoprenaline HCl (Isoproterenol HCl) | 51-30-9 | Isoprenaline HCL (NCIc55630; NCI c55630; Isoproterenol), the hydrochloride salt of Isoprenaline, is a non-selective beta-adrenergic receptor agonist that has been used for the treatment of bradycardia and heart block. |
|
V33550 | Ivabradine D3 HCl | 1217809-61-4 | Ivabradine D3 HCl is the tri-deuterated form and hydrochloride salt of Ivabradine used as an internal standard for the quantification of ivabradine, which is a cardiac pacemaker current (If) inhibitor approved in 2015 for symptomatic management of stable angina pectoris,stable heart-related chest pain and heart failure. |
|
V1142 | Ivabradine HCl (Procoralan) | 148849-67-6 | Ivabradine HCl (Corlentor; Corlanor; Coraxan; Ivabid; Procoralan; Coralan; S16257; S 16257; S-16257; Bradia), the hydrochloride salt of Ivabradine, is a novel and potent cardiac pacemaker current (If) inhibitor with antianginal effects. |
|
V71301 | Ivabradine-d6 hydrochloride | 2070009-63-9 | Ivabradine-d6 (HCl) is the deuterium labelled form of Ivabradine HCl. |
|
V22990 | JP-1302 HCl | 1259314-65-2 | JP-1302 HCl, the hydrochloride salt form of JP1302, is a novel, selective, high affinity and potent α2C-adrenoceptor antagonist with a Ki of 28 nM and a Kb value (antagonist activity) of 16 nM. |
|
V71338 | JP1302 | 80259-18-3 | JP1302 is a selective, high-affinity α2C-adrenoceptor antagonist (inhibitor) with a Kb value of 16 nM and a Ki of 28 nM for human α2C receptors. |
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