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JNK

JNK

JNK (c-Jun N-terminal kinase), a kinase subfamily belonging to the MAPK, is activated in response to various stress stimuli and possesses a wide variety of regulatory functions.Three isoforms of the serine/threonine protein kinase JNK family (JNK1, JNK2, and JNK3) exist. JNKs play a role in the development and progression of many pathologies, including cancer, inflammatory diseases, cardiovascular and metabolic disorders, and neurodegenerative diseases.

JNKs are triggered by a phosphorylation cascade that typically involves two different upstream kinases, the so-called MAP kinase kinase kinases (MAP3K, MKKK) and the MAP kinase kinases (MAP2K; MKK). This process is similar to that used to activate the other MAP kinases. JNKs are triggered by MKK4 and MKK7 at the MAP2K level; the former is a shared activator of the JNK and p38 MAP kinase signaling pathways. The JNK cascade is a component of a complicated signaling network since it crosses numerous other routes at different places.

JNK related products

Structure Cat No. Product Name CAS No. Product Description
6-苯基咪唑并[2,1-B]-1,3,4-噻二唑-2-磺酰胺 V10399 AEG-3482 63735-71-7 AEG-3482 is a novel and potent antiapoptotic compound.
8-羟基依法韦伦 V51559 8-Hydroxy-efavirenz 205754-33-2 major metabolite of Efavirenz
AS601245 V3735 AS601245 345987-15-7 AS601245 is an inhibitor of the JNK signaling pathway, it showed high JNK1/2/3 inhibition with IC50 of 150, 220, and 70 nM respectively.
BI-78D3 V2665 BI-78D3 883065-90-5 BI-78D3 (also known as JNK Inhibitor X) is a novel, potent and competitive JNK inhibitor with IC50 of 280nM.
CC-401 V2078 CC-401 395104-30-0 CC-401 (CC401) is a potent, specific, 2nd generation and ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
CC-401盐酸盐 V2978 CC-401 HCl 1438391-30-0 CC-401 HCl (CC401 hydrochloride) is an anthrapyrazolone-based inhibitor of c-Jun N terminal kinase (JNK) with potential anticancer activity.
CC-90001 V2263 CC-90001 1403859-14-2 CC-90001 (CC90001; CC 90001) is a novel, potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with potential anti-fibrotic activity.
CMX-8933 V87071 CMX-8933 146877-90-9 CMX-8933 is an octapeptide fragment of the goldfish brain neurotrophic factor ependymin.
DB07268 V19209 DB07268 929007-72-7 DB07268 is a potent and specific JNK1 inhibitor (antagonist) with IC50 of 9 nM.
DN-1289 V80005 DN-1289 3026597-15-6 DN-1289 is an orally bioactive, selective inhibitor targeting dileucine zipper kinase (DLK; IC50=17 nM) and leucine zipper-bearing kinase (LZK; IC50=40 nM).
DTP3 V0474 DTP3 1809784-29-9 DTP3 (DTP-3) is a novel, potent and selective inhibitor of GADD45β/MKK7 ((growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) with potential anticancer activity.
IQ-1S V22646 IQ-1S 23146-22-7 IQ-1S is a potent and selective c-Jun N-Terminal Kinase Inhibitor.
JIP-1 (153-163) V51553 JIP-1 (153-163) 438567-88-5 peptide-based JNK inhibitor
JIP-1(153-163) TFA V87072 JIP-1(153-163) TFA JIP-1(153-163) TFA (TI-JIP TFA) is a peptide inhibitor of c-JNK.
JIP-1(153-163) TFA (T1-JIP TFA) V80447 JIP-1(153-163) TFA (T1-JIP TFA) JIP-1(153-163) TFA (TI-JIP TFA) is a bioactive peptide inhibitor of c-JNK.
JNK-1-IN-2 V80254 JNK-1-IN-2 JNK-1-IN-2 (Compound c6) is a JNK-1 inhibitor (IC50= 33.5 nM).
JNK-IN-12 V80459 JNK-IN-12 JNK-IN-12 (compound P2) is a mitochondria-targeted JNK inhibitor (IC50=66.3 nM), consisting of a mitochondria-specific cell-penetrable peptide and JNK-specific inhibitor SP600125.
JNK-IN-13 V74393 JNK-IN-13 345986-38-1 JNK-IN-13 (compound 1) is a potent and specific JNK inhibitor (antagonist) with IC50s of 290 nM and 500 nM for JNK3 and JNK2, respectively.
JNK-IN-15, Cell-Permeable V85692 JNK-IN-15, Cell-Permeable
JNK-IN-15, Cell-Permeable, Negative Control V85683 JNK-IN-15, Cell-Permeable, Negative Control
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