β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription.The CTNNB1 gene in humans encodes the CTNNB1 protein. The cadherin protein complex subunit -catenin functions as an intracellular signal transducer in the Wnt signaling pathway.It is a homolog of -catenin and a member of the catenin protein family. Hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian, and endometrial cancer are just a few of the cancers that have been linked to mutations and overexpression of -catenin. The beta-catenin destruction complex, and in particular the adenomatous polyposis coli (APC) protein, which is encoded by the tumor-suppressing APC gene, regulates and annihilates -catenin. As a result, genetic APC gene mutation is strongly associated with cancers, particularly colorectal cancer brought on by familial adenomatous polyposis (FAP).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1350 | ICG-001 | 780757-88-2 | ICG-001 (ICG001; ICG 001) is a novel and potent inhibitor ofβ-catenin/TCFmediated transcription. |
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V1355 | IWP-2 | 686770-61-6 | IWP-2 (IWP 2, IWP2) is a novel and potent inhibitor of Wnt processing and secretion (specifically, Porcn-mediated Wnt palmitoylation) with potential antineoplastic activity. |
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V1356 | IWP-L6 | 1427782-89-5 | IWP-L6 (IWPL6;IWPL-6;Porcn Inhibitor III) is an inhibitor of Porcn (EC50 = 0.5 nM), which is also known as Porcupine and is an enzyme catalyzing the palmitoylation of Wnt proteins. |
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V1351 | IWR-1-endo | 1127442-82-3 | IWR-1-endo (also known as IWR 1-endo;IWR1; IWR-1) is a potenttankyrase inhibitor of the Wnt pathway with potential antitumor activity. |
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V1354 | KY02111 | 1118807-13-8 | KY02111 (KY 02111; KY-02111) is a potent and selective inhibitor of the Wnt signaling pathway with important biological activity. |
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V2725 | LF3 | 664969-54-4 | LF3 is a specific antagonist of the β-Catenin/TCF4 interaction with antitumor activity; it acts by disrupting the interaction between β-catenin and TCF4 with an IC50of 1.65 μM. |
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V1353 | LGK974 (WNT974; LGK974) | 1243244-14-5 | LGK-974 (formerly known as WNT-974;LGK-974 and NVP-LGK974) is a novel potent, orally bioavailable and specific/selectivePORCN (Porcupine) inhibitor with potential anticancer activity. |
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V1357 | WIKI4 | 838818-26-1 | WIKI4 (WIKI 4; WIKI-4) is a novel and potent Tankyrase inhibitor with potential anticancer activity. |
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V1352 | Wnt-C59 | 1243243-89-1 | Wnt-C59 (also called Wnt-C 59;C59;Wnt-C-59; C-59) is a novel, highly potent and orally bioactive PORCN (porcupine) inhibitor with potential antineoplastic activity. |
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V1349 | XAV-939 | 284028-89-3 | XAV-939 (also called NVP-XAV 939;XAV939;NVP XAV939;XAV-939) is a potentinhibitor of the TNKS (Tankyrase) with IC50 values of 0.011 and 0.004 μM for inhibiting TNKS1 and TNKS2 respectively. |
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