Mineralocorticoid receptor (MR) is an intracellular steroid hormone receptor, and a member of the nuclear receptor superfamily, that mediates the physiological action of two important adrenal steroids, aldosterone and cortisol.The glucocorticoid receptor (GR) and the mineralocorticoid receptor (MCR) are closely related, and MCR can bind both MCR and GR hormones indifferently. Aldosterone, the mineralocorticoid receptor's ligand, plays a critical role in sodium reabsorption and blood pressure regulation by activating the mineralocorticoid receptor in the distal nephron. Aldosterone and the human mineralocorticoid receptor tandem also play significant regulatory roles in the cardiovascular and nervous systems in addition to controlling blood pressure and sodium balance.
In sodium-transporting tight epithelia, including the distal nephron, colon, lung, salivary and sweat glands, mineralocorticoid receptor plays a role in the regulation of hydroelectrolytic homeostasis. The enzyme 11-hydroxysteroid dehydrogenase 2 (11-HSD2), which transforms active glucocorticoids into inactive metabolites, provides the mineralocorticoid specificity of aldosterone action in such epithelial target cells. Additionally, non-epithelial tissues like the heart, certain regions of the brain, large blood vessels, and mononuclear leukocytes express the mineralocorticoid receptor. After interacting with the consensus glucocorticoid response element (GRE) sequences, the ligand-activated mineralocorticoid receptor is translocated in the nucleus and functions as a transcription factor. The target genes of the mineralocorticoid receptor may either be activated or have their transcription inhibited.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V67757 | (Rac)-Finerenone ((Rac)-BAY 94-8862) | 1050477-27-4 | (Rac)-Finerenone ((Rac)-BAY 94-8862) is the racemate of Finerenone. |
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V67755 | Baxdrostat | 1428652-17-8 | Baxdrostat is an aldosterone synthase inhibitor. |
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V67754 | Canrenoate potassium (potassium canrenate; Aldadiene potassium; SC-14266) | 2181-04-6 | Canrenoate potassium is a canrenone-releasing precursor and a potent competitive mineralocorticoid receptor antagonist. |
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V2139 | Eplerenone (Epoxymexrenone; CGP 30083) | 107724-20-9 | Eplerenone (also known as CGP 30083, Inspra,SC-66110) is a potent and selective mineralocorticoid receptor antagonist with an IC50 of 0.36 μM, it blocks the action of aldosterone, used to control high blood pressure. |
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V14606 | Fludrocortisone Acetate | 514-36-3 | Fludrocortisone Acetate, the acetate form of the synthetic corticosteroid fludrocortisone, is a potent mineralocorticoid receptor agonist. |
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V67756 | Ocedurenone (KBP-5074) | 1359969-24-6 | Ocedurenone is a corticosteroid receptor blocker (antagonist). |
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V2622 | Osilodrostat (LCI699) | 928134-65-0 | Osilodrostat (LCI699; LCI-699;Isturisa) is a novel and potent inhibitor of 11β-hydroxylase and approved medication for the treatment of adults with Cushings disease. |
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