AhR

AhR

Aryl Hydrocarbon Receptor (AhR or AHR) is a cytoplasmic receptor and transcription factor that is a member of the basic helix-loop-helix transcription factor family. Exogenous and endogenous ligands of various types can either activate or inhibit the AhR. When it comes to immunity and tissue homeostasis, AhR plays a crucial role. A variety of structurally different substances, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), can activate AhR.

Indigooids, heme metabolites, eicosanoids, tryptophan derivatives, and equilenin are examples of endogenous ligands. Polycyclic aromatic hydrocarbons, polychlorinated biphenyls, natural substances, and small molecule substances are examples of exogenous ligands. Because AhR ligands differ in their shapes and characteristics, their interactions with AhR have unique biological effects.

Hsp90, AIP, and p23 are examples of chaperone proteins that sequester unliganded AHR in the cytoplasm. AHR moves into the nucleus after ligand binding and forms a heterodimer with ARNT. The aryl hydrocarbon response elements, which are found in the regulatory regions of target genes like CYP1A1, CYP1B1, and TIPARP, are where the AHR-ARNT complex regulates transcription by binding with high affinity.

AhR related products

Structure Cat No. Product Name CAS No. Product Description
V4433 BAY-218 2162982-11-6 BAY-218 (BAY218) is a novel, potent and selective small-molecule AhR (aryl hydrocarbon receptor) inhibitor with anticancer activities.
V2199 BAY2416964 2242464-44-2 BAY-2416964 (BAY 2416964) is a novel, potent and orally bioactive antagonist of aryl hydrocarbon receptor (AHR) with the potential for treating solid tumors.
V0952 CH-223191 301326-22-7 CH-223191 (CH 223191; CH223191) is a potent and specific/selective aryl hydrocarbon receptor (AhR) antagonist with important biological activity.
V4534 GNF351 1227634-69-6 GNF351 (GNF-351) is a novel and potent fullaryl hydrocarbon receptor (AHR)antagonist with the potential to be used as new drugs in dermatology.
V4035 PDM-11 1032508-03-4 PDM-11 is a novel selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist and an antioxidant that is a trans-resveratrol analog.
V0951 StemRegenin 1 (SR1) 1227633-49-9 StemRegenin 1(abbreviated as SR1; SR-1),a purine derivative, is a potent antagonist of the aryl hydrocarbon receptor(AhR)with important biological activity.
V0953 UM729 1448723-60-1 This product has been discontinued from InvivoChem.
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