Aryl Hydrocarbon Receptor (AhR or AHR) is a cytoplasmic receptor and transcription factor that is a member of the basic helix-loop-helix transcription factor family. Exogenous and endogenous ligands of various types can either activate or inhibit the AhR. When it comes to immunity and tissue homeostasis, AhR plays a crucial role. A variety of structurally different substances, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), can activate AhR.
Indigooids, heme metabolites, eicosanoids, tryptophan derivatives, and equilenin are examples of endogenous ligands. Polycyclic aromatic hydrocarbons, polychlorinated biphenyls, natural substances, and small molecule substances are examples of exogenous ligands. Because AhR ligands differ in their shapes and characteristics, their interactions with AhR have unique biological effects.
Hsp90, AIP, and p23 are examples of chaperone proteins that sequester unliganded AHR in the cytoplasm. AHR moves into the nucleus after ligand binding and forms a heterodimer with ARNT. The aryl hydrocarbon response elements, which are found in the regulatory regions of target genes like CYP1A1, CYP1B1, and TIPARP, are where the AHR-ARNT complex regulates transcription by binding with high affinity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4433 | BAY-218 | 2162982-11-6 | BAY-218 (BAY218) is a novel, potent and selective small-molecule AhR (aryl hydrocarbon receptor) inhibitor with anticancer activities. |
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V2199 | BAY2416964 | 2242464-44-2 | BAY-2416964 (BAY 2416964) is a novel, potent and orally bioactive antagonist of aryl hydrocarbon receptor (AHR) with the potential for treating solid tumors. |
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V0952 | CH-223191 | 301326-22-7 | CH-223191 (CH 223191; CH223191) is a potent and specific/selective aryl hydrocarbon receptor (AhR) antagonist with important biological activity. |
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V4534 | GNF351 | 1227634-69-6 | GNF351 (GNF-351) is a novel and potent fullaryl hydrocarbon receptor (AHR)antagonist with the potential to be used as new drugs in dermatology. |
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V4035 | PDM-11 | 1032508-03-4 | PDM-11 is a novel selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist and an antioxidant that is a trans-resveratrol analog. |
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V0951 | StemRegenin 1 (SR1) | 1227633-49-9 | StemRegenin 1(abbreviated as SR1; SR-1),a purine derivative, is a potent antagonist of the aryl hydrocarbon receptor(AhR)with important biological activity. |
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V0953 | UM729 | 1448723-60-1 | This product has been discontinued from InvivoChem. |
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