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DHFR

DHFR

Dihydrofolate reductase (DHFR), which is found in both prokaryotic and eukaryotic cells, catalyzes the conversion of dihydrofolate to tetrahydrofolate using NADPH. In addition to treating bacterial, fungal, and mycobacterial infections, DHFR inhibitors are frequently used to treat malaria and other protozoal infections.

DHFR related products

Structure Cat No. Product Name CAS No. Product Description
4′-DTMP V71989 4′-DTMP 21253-58-7 4′-DTMP is a DHFR inhibitor (antagonist) with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R).
DHFR-IN-11 V80014 DHFR-IN-11 DHFR-IN-11 (compound 6b) is a DHFR inhibitor that can suppress Mycobacterium tuberculosis (TB) DHFR enzyme with IC50 of 5.70 μM.
DHFR-IN-12 V78500 DHFR-IN-12 DHFR-IN-12 (Compound 5c) is a DHFR inhibitor (antagonist) with good anti-bacterial effect.
DHFR-IN-13 V85466 DHFR-IN-13
DHFR-IN-14 V84353 DHFR-IN-14
DHFR-IN-15 V84254 DHFR-IN-15
DHFR-IN-16 V87372 DHFR-IN-16 DHFR-IN-16 (compound 8d) is a dihydrofolate reductase (DHFR) inhibitor (IC50=0.199 μM), which can be used in anti-infection research.
DHFR-IN-18 V87370 DHFR-IN-18 DHFR-IN-18 (compound 19D) is a DHFR inhibitor.
DHFR-IN-19 V87371 DHFR-IN-19 41927-06-4 DHFR-IN-19 (Compound 2g) is a selective inhibitor of TbDHFR with Ki of 9 nM.
DHFR-IN-20 V96935 DHFR-IN-20 DHFR-IN-20 (Compound LA1) is a Plasmodium falciparum dihydrofolate reductase (DHFR) inhibitor with Ki values of 0.16, 0.30, and 6.6 nM for PfDHFR-WT, PfDHFR-QM, and HsDHFR, respectively.
DHFR-IN-21 V94874 DHFR-IN-21 DHFR-IN-21 (Compound 5p) is a dihydrofolate reductase (DHFR) inhibitor.
DHFR-IN-5 V71990 DHFR-IN-5 1142407-81-5 DHFR-IN-5 is a potent and orally bioactive dihydrofolate reductase (DHFR) inhibitor (antagonist) with a Ki of 0.54 nM against Plasmodium falciparum mutants.
DHFR-IN-5 hydrochloride V95332 DHFR-IN-5 hydrochloride 1142407-60-0 DHFR-IN-5 hydrochloride is a potent, oral dihydrofolate reductase (DHFR) inhibitor with a Ki value of 0.54 nM against Plasmodium falciparum mutants.
Phototrexate ((E)-azoMTX) V84543 Phototrexate ((E)-azoMTX) 2268033-83-4
乙胺嘧啶 V0849 Pyrimethamine 58-14-0 Pyrimethamine(Malocid;Khloridin;BW 50-63;NCI-C01683; BW50-63; Daraprim; NSC 3061; Tindurin; WR-297;RP-4753) is a potent dihydrofolate reductase (DHFR) inhibitor which isused as an antimalarialandantiprotozoaldrug.
亚叶酸钙 V2027 Leucovorin Calcium 1492-18-8 Leucovorin calcium, a reduced folic acid andan active metabolite of folic acid, is a derivative of folic acid which can be used to increase levels of folic acid under conditions favoring folic acid inhibition.
亚叶酸钙 V25456 Leucovorin calcium hydrate 6035-45-6 Leucovorin calcium, a reduced folic acid andan active metabolite of folic acid(also known as folinic acid and citrovorum factor), is a derivative of folic acid which can be used to increase levels of folic acid under conditions favoring folic acid inhibition.
培美曲塞二钠水合物 V0851 Pemetrexed Disodium Hydrate 357166-30-4 Pemetrexed Disodium Hydrate (LY-231514;HSDB-7316; trade name Alimta), the hydrated disodium salt of Pemetrexed which is a synthetic pyrimidine-based antifolate, is a novel antifolate and antimetabolite anticancer drug targeting TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
普拉曲沙特 V0848 Pralatrexate (racemic) 146464-95-1 Pralatrexate (PDX; trade name Folotyn), an antifolate which is structurally a folate analog, is a potent and selective inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities.
氨基蝶呤 V5235 Aminopterin (4-Aminofolic acid) 54-62-6 Aminopterin (4-Aminofolic acid; APGA) is a novel and synthetic folic acid derivative used as a rodenticide that has been shown to be teratogenic, but whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis.
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