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DHFR

DHFR

Dihydrofolate reductase (DHFR), which is found in both prokaryotic and eukaryotic cells, catalyzes the conversion of dihydrofolate to tetrahydrofolate using NADPH. In addition to treating bacterial, fungal, and mycobacterial infections, DHFR inhibitors are frequently used to treat malaria and other protozoal infections.

DHFR related products

Structure Cat No. Product Name CAS No. Product Description
1954U89 V112532 1954U89 150057-49-1 1954U89 is a potent, lipid-soluble, orally effective dihydrofolate reductase (DHFR) inhibitor.
4′-DTMP V71989 4′-DTMP 21253-58-7 4′-DTMP is a DHFR inhibitor (antagonist) with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R).
DAMPA methyl ester V111109 DAMPA methyl ester 23853-09-0 DAMPA methyl ester is a dihydrofolate reductase inhibitor.
DHFR-IN-11 V80014 DHFR-IN-11 DHFR-IN-11 (compound 6b) is a DHFR inhibitor that can suppress Mycobacterium tuberculosis (TB) DHFR enzyme with IC50 of 5.70 μM.
DHFR-IN-12 V78500 DHFR-IN-12 DHFR-IN-12 (Compound 5c) is a DHFR inhibitor (antagonist) with good anti-bacterial effect.
DHFR-IN-13 V85466 DHFR-IN-13
DHFR-IN-14 V84353 DHFR-IN-14
DHFR-IN-15 V84254 DHFR-IN-15
DHFR-IN-16 V87372 DHFR-IN-16 DHFR-IN-16 (compound 8d) is a dihydrofolate reductase (DHFR) inhibitor (IC50=0.199 μM), which can be used in anti-infection research.
DHFR-IN-18 V87370 DHFR-IN-18 DHFR-IN-18 (compound 19D) is a DHFR inhibitor.
DHFR-IN-19 V87371 DHFR-IN-19 41927-06-4 DHFR-IN-19 (Compound 2g) is a selective inhibitor of TbDHFR with Ki of 9 nM.
DHFR-IN-20 V96935 DHFR-IN-20 DHFR-IN-20 (Compound LA1) is a Plasmodium falciparum dihydrofolate reductase (DHFR) inhibitor with Ki values of 0.16, 0.30, and 6.6 nM for PfDHFR-WT, PfDHFR-QM, and HsDHFR, respectively.
DHFR-IN-21 V94874 DHFR-IN-21 DHFR-IN-21 (Compound 5p) is a dihydrofolate reductase (DHFR) inhibitor.
DHFR-IN-24 V112545 DHFR-IN-24 1088704-78-2 DHFR-IN-24 is a benzothiazole derivative and belongs to the class of dihydrofolate reductase (DHFR) inhibitors.
DHFR-IN-25 V112662 DHFR-IN-25 3002069-20-4 DHFR-IN-25 (compound N2) is a dihydrofolate reductase (DHFR) inhibitor.
DHFR-IN-5 V71990 DHFR-IN-5 1142407-81-5 DHFR-IN-5 is a potent and orally bioactive dihydrofolate reductase (DHFR) inhibitor (antagonist) with a Ki of 0.54 nM against Plasmodium falciparum mutants.
DHFR-IN-5 hydrochloride V95332 DHFR-IN-5 hydrochloride 1142407-60-0 DHFR-IN-5 hydrochloride is a potent, oral dihydrofolate reductase (DHFR) inhibitor with a Ki value of 0.54 nM against Plasmodium falciparum mutants.
Methotrexate diethyl ester V111055 Methotrexate diethyl ester 43170-88-3 Methotrexate diethyl ester is a potent dihydrofolate reductase inhibitor.
Phomarin V104782 Phomarin 6866-87-1 Phomarin is a dihydrofolate reductase (DHFR) inhibitor with antimalarial activity.
Phototrexate ((E)-azoMTX) V84543 Phototrexate ((E)-azoMTX) 2268033-83-4
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