Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments.In humans, there are 45 kinesin proteins spread across 14 different subclasses of the kinesin motor protein family. It has been established that many of these proteins—or their orthologues—have crucial roles to play in both the mitotic and meiotic cell cycles. Based on where their motor domains are located, kinesins can also be divided into three groups: internal, C-terminal, and N-terminal kinesins. Traditional kinesin moves in a coordinated, hand-over-hand manner along a microtubule protofilament, acting as a dimer.
Kinesins play critical roles in the progression of the cell cycle, cytokinesis, spindle formation, microtubule dynamics, and chromosome segregation. Kinesins typically play roles in diseases involving pathogen transport, pathogen transport defects, or cell division.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V28939 | (R)-Filanesib | 885060-08-2 | R)-Filanesib, theR-enantiomer of ARRY-520,is a novel and potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM) with anticancer activity. |
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V54364 | (S)-Monastrol ((+)-Monastrol) | 254753-54-3 | (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic motor protein Eg5 and has antiproliferation effects on a variety of cancer cell lines. |
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V96682 | (Z/E)-GW406108X | 265098-01-9 | (Z/E)-GW406108X is a mixture of different configurations of GW406108X. |
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V2993 | Dimethylenastron | 863774-58-7 | Dimethylenastron, a quinazoline-thione analog, isa potent, cell-permeable, specific, and reversiblemitotic kinesin 5 (Eg5) inhibitor with IC50 of 200 nM. |
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V88690 | Anticancer agent 190 | Anticancer agent 190 (compound 3e) is an inhibitor targeting KSP (Kinesin) and PI3Kδ, and has anti-breast cancer efficacy. | |
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V99887 | CENP-E-IN-2 | CENP-E-IN-2 (compound 3) is a light-controlled CENP-E inhibitor with a pIC50 of 6.82 in the absence of light and 5.85 in the presence of 365 nm light. | |
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V100329 | CENP-E-IN-3 | CENP-E-IN-3 (compound 4) is a potent CENP-E inhibitor. | |
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V79249 | Eg5-IN-1 | 3026790-10-0 | Eg5-IN-1 (compound 6c) is a potent inhibitor of the kinesin family motor protein (Eg5) with IC50 of 1.97 µM. |
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V20498 | EMD534085 | 858668-07-2 | EMD534085 is a potent and specific inhibitor of mitotic kinesin-5 with IC50 of 8 nM. |
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V86051 | Filanesib hydrochloride (ARRY-520 hydrochloride) | 1385020-40-5 | |
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V86008 | Ispinesib-d5 (SB-715992-d5) | ||
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V2906 | K858 | 72926-24-0 | K-858 is a novel, potent and ATP-uncompetitive inhibitor of mitotic kinesin Eg5 that has potential antitumor activity. |
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V104031 | KIF18A-IN-14 | 3051552-75-8 | |
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V104032 | KIF18A-IN-15 | 3051552-64-5 | |
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V104033 | KIF18A-IN-16 | 3033981-01-7 | |
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V104470 | KSP ligand 1 | 1802248-16-3 | |
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V85091 | LG157 | 2840558-89-4 | |
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V84280 | MC-Val-Cit-PAB-Ispinesib | 1629737-40-1 | |
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V16230 | MK-0731 | 845256-65-7 | MK-0731 (MK0731; MK 0731) is a potent kinesin spindle protein (KSP) inhibitor with potential anticancer activity. |
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V75810 | PF-2771 | 2070009-55-9 | PF-2771 is a selective centromere protein E (CENP-E) inhibitor (antagonist) with IC50 of 16.1 nM and anti-tumor activity. |
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