Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments.In humans, there are 45 kinesin proteins spread across 14 different subclasses of the kinesin motor protein family. It has been established that many of these proteins—or their orthologues—have crucial roles to play in both the mitotic and meiotic cell cycles. Based on where their motor domains are located, kinesins can also be divided into three groups: internal, C-terminal, and N-terminal kinesins. Traditional kinesin moves in a coordinated, hand-over-hand manner along a microtubule protofilament, acting as a dimer.
Kinesins play critical roles in the progression of the cell cycle, cytokinesis, spindle formation, microtubule dynamics, and chromosome segregation. Kinesins typically play roles in diseases involving pathogen transport, pathogen transport defects, or cell division.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V28939 | (R)-Filanesib | 885060-08-2 | R)-Filanesib, theR-enantiomer of ARRY-520,is a novel and potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM) with anticancer activity. |
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V54364 | (S)-Monastrol ((+)-Monastrol) | 254753-54-3 | (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic motor protein Eg5 and has antiproliferation effects on a variety of cancer cell lines. |
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V96682 | (Z/E)-GW406108X | 265098-01-9 | (Z/E)-GW406108X is a mixture of different configurations of GW406108X. |
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V2993 | Dimethylenastron | 863774-58-7 | Dimethylenastron, a quinazoline-thione analog, isa potent, cell-permeable, specific, and reversiblemitotic kinesin 5 (Eg5) inhibitor with IC50 of 200 nM. |
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V116852 | ALN-12115 | 3031494-36-4 | ALN-12115 is a small interfering RNA (siRNA) that targets kinesin microtubules (KSP). It is one of the siRNAs in ALN-VSP. |
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V116857 | ALN-12115 sodium | Sodium ALN-12115 is a small interfering RNA (siRNA) that targets kinesin microtubules (KSP). It is a type of siRNA in ALN-VSP. | |
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V88690 | Anticancer agent 190 | Anticancer agent 190 (compound 3e) is an inhibitor targeting KSP (Kinesin) and PI3Kδ, and has anti-breast cancer efficacy. | |
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V111001 | CCT368772 | 2902671-74-1 | CCT368772 (compound 35) is a selective kinin HSET inhibitor (HSET ADP-Glo IC50 = 0.019 μM). |
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V99887 | CENP-E-IN-2 | CENP-E-IN-2 (compound 3) is a light-controlled CENP-E inhibitor with a pIC50 of 6.82 in the absence of light and 5.85 in the presence of 365 nm light. | |
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V100329 | CENP-E-IN-3 | CENP-E-IN-3 (compound 4) is a potent CENP-E inhibitor. | |
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V112304 | Cenpemlin | 292031-97-1 | Cenpemlin is a CENP-M inhibitor that disrupts the CENP-M/CENP-L interaction. |
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V79249 | Eg5-IN-1 | 3026790-10-0 | Eg5-IN-1 (compound 6c) is a potent inhibitor of the kinesin family motor protein (Eg5) with IC50 of 1.97 µM. |
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V20498 | EMD534085 | 858668-07-2 | EMD534085 is a potent and specific inhibitor of mitotic kinesin-5 with IC50 of 8 nM. |
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V86051 | Filanesib hydrochloride (ARRY-520 hydrochloride) | 1385020-40-5 | |
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V117116 | Ispinesib mesylate | 514820-03-2 | Ispinesib (SB-715992) mesylate is a specific inhibitor of spindle kinesin KSP with a Ki app value of 1.7 nM. |
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V86008 | Ispinesib-d5 (SB-715992-d5) | ||
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V2906 | K858 | 72926-24-0 | K-858 is a novel, potent and ATP-uncompetitive inhibitor of mitotic kinesin Eg5 that has potential antitumor activity. |
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V104031 | KIF18A-IN-14 | 3051552-75-8 | KIF18A-IN-14 (Compound Example 81) is a KIF18A inhibitor. |
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V104032 | KIF18A-IN-15 | 3051552-64-5 | KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor with two forms, EX36-A and its enantiomer EX36-B, both with IC50 of 0.01-0.1 μM. |
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V104033 | KIF18A-IN-16 | 3033981-01-7 | KIF18A-IN-16 (compound 15) is a fused-ring KIF18A inhibitor. |
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