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Kinesin

Kinesin

Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments.In humans, there are 45 kinesin proteins spread across 14 different subclasses of the kinesin motor protein family. It has been established that many of these proteins—or their orthologues—have crucial roles to play in both the mitotic and meiotic cell cycles. Based on where their motor domains are located, kinesins can also be divided into three groups: internal, C-terminal, and N-terminal kinesins. Traditional kinesin moves in a coordinated, hand-over-hand manner along a microtubule protofilament, acting as a dimer.

Kinesins play critical roles in the progression of the cell cycle, cytokinesis, spindle formation, microtubule dynamics, and chromosome segregation. Kinesins typically play roles in diseases involving pathogen transport, pathogen transport defects, or cell division.

Kinesin related products

Structure Cat No. Product Name CAS No. Product Description
(R)-Filanesib V28939 (R)-Filanesib 885060-08-2 R)-Filanesib, theR-enantiomer of ARRY-520,is a novel and potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM) with anticancer activity.
(S)-Monastrol ((+)-Monastrol) V54364 (S)-Monastrol ((+)-Monastrol) 254753-54-3 (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic motor protein Eg5 and has antiproliferation effects on a variety of cancer cell lines.
Dimethylenastron V2993 Dimethylenastron 863774-58-7 Dimethylenastron, a quinazoline-thione analog, isa potent, cell-permeable, specific, and reversiblemitotic kinesin 5 (Eg5) inhibitor with IC50 of 200 nM.
Eg5-IN-1 V79249 Eg5-IN-1 Eg5-IN-1 (compound 6c) is a potent inhibitor of the kinesin family motor protein (Eg5) with IC50 of 1.97 µM.
EMD534085 V20498 EMD534085 858668-07-2 EMD534085 is a potent and specific inhibitor of mitotic kinesin-5 with IC50 of 8 nM.
Filanesib (ARRY520) V4726 Filanesib (ARRY520) 885060-09-3 Filanesib (formerly also known as ARRY-520) is a novel, potent and synthetic small molecule inhibitor of kinesin spindle protein (KSP) with anticancer activity.
Filanesib hydrochloride (ARRY-520 hydrochloride) V86051 Filanesib hydrochloride (ARRY-520 hydrochloride) 1385020-40-5
Ispinesib-d5 (SB-715992-d5) V86008 Ispinesib-d5 (SB-715992-d5)
K858 V2906 K858 72926-24-0 K-858 is a novel, potent and ATP-uncompetitive inhibitor of mitotic kinesin Eg5 that has potential antitumor activity.
LG157 V85091 LG157 2840558-89-4
Litronesib V4905 Litronesib 910634-41-2 Litronesib (formerly also known as LY2523355; LY-2523355; KF-8961) is a novel, potent and selective inhibitor of the kinesin-related motor protein Eg5 with potential anticancer activity.
MC-Val-Cit-PAB-Ispinesib V84280 MC-Val-Cit-PAB-Ispinesib 1629737-40-1
MK-0731 V16230 MK-0731 845256-65-7 MK-0731 (MK0731; MK 0731) is a potent kinesin spindle protein (KSP) inhibitor with potential anticancer activity.
Monastrol V2718 Monastrol 329689-23-8 Monastrol is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cell lines.
PF-2771 V75810 PF-2771 2070009-55-9 PF-2771 is a selective centromere protein E (CENP-E) inhibitor (antagonist) with IC50 of 16.1 nM and anti-tumor activity.
PVZB1194 V54365 PVZB1194 1141768-04-8 PVZB1194 is a biphenyl-type inhibitor of the kinase spindle protein Eg5 or KIF11.
Solidagonic acid V54366 solidagonic acid 19941-91-4 Solidagonic acid inhibits HSET motor activity by promoting the transition of abnormal unipolar spindles to bipolar spindles.
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