MAP3Ks (Mitogen-activated protein kinase kinase kinases), the top components of MAPK cascades, provide specificity for stimulus-dependent activation of MAP2K-MAPK pathways through unique protein-protein interactions and phosphorylation of signaling effectors.TAK1, ASK1, A-Raf, and C-Raf are MAP3Ks with highly divergent gene numbers and structures.

A three-step sequential phosphorylation cascade made up of MAPK, MAP2K, and MAP3K is known as the MAPK system. The MAPK family includes the proteins ERK, p38 MAPK, and JNK, all of which are known to be activated by mechanical stimuli. The activation of multiple MAP3Ks provides the spatiotemporal regulation of the MAPK pathways, which induces a wide range of physiological responses necessary for determining cell fate, such as cytokine production, survival, differentiation, and apoptosis. MAP3Ks serve as "platforms to integrate MAPK signaling."

MAP3K related products

Structure Cat No. Product Name CAS No. Product Description
ASK1-IN-1 V3102 ASK1-IN-1 1262041-49-5 ASK1-IN-1 is a potent inhibitor of the apoptosis signal regulating kinase 1 (ASK1) inhibitor (Compound 4 from patent WO2016025474A1).
AZ-TAK1 V74395 AZ-TAK1 1413440-36-4 AZ-TAK1 is an ATP-competitive, small molecule inhibitor of TAK1 that dephosphorylates TAK1, p38, and IκB-α in lymphoma cells.
DDO-3711 V51189 DDO-3711 2673364-10-6 PP5-recruiting phosphatase recruitment chimeras (PHORCs)
IACS-52825 V74397 IACS-52825 2640376-72-1 IACS-52825 is a potent and specific DLK inhibitor (antagonist) with a Kd of 1.3 nM that may be utilized to study chemotherapy-induced peripheral neuropathy.
JT21-25 V83375 JT21-25 2996864-57-2
Selonsertib V2973 Selonsertib 1448428-04-3 Selonsertib (Also known as GS-4997) is a highly selective and potent once-daily orally available inhibitor of ASK1 (apoptosis signal-regulating kinase 1) with a pIC50 of 8.3±0.07.
SM1-71 V35537 SM1-71 2088179-99-9 SM1-71 is a potent TAK1 inhibitor (antagonist) with a Ki of 160 nM and can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B , MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.
SW083688 V74396 SW083688 422281-45-6 SW083688 is a potent and selective TAOK2 (Thousand-And-One Kinase 2) inhibitor (IC50 = 1.3 umol/L).
TAK1-IN-2 V74399 TAK1-IN-2 2763213-98-3 TAK1-IN-2 is a potent and specific TAK1 inhibitor (antagonist) with IC50> value of 2 nM.
TAK1-IN-3 V74398 TAK1-IN-3 494772-87-1 TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor.
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